Detalhe da pesquisa
1.
Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors.
Bioorg Med Chem Lett
; 50: 128352, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34481987
2.
Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.
J Chem Inf Model
; 60(11): 5457-5474, 2020 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32813975
3.
Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk.
Bioorg Med Chem Lett
; 28(21): 3419-3424, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30290988
4.
Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit.
Bioorg Med Chem Lett
; 28(17): 2939-2944, 2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30122225
5.
Optimization of the efflux ratio and permeability of covalent irreversible BTK inhibitors.
Bioorg Med Chem Lett
; 28(20): 3307-3311, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30243592
6.
Recent progress towards clinically relevant ATP-competitive Akt inhibitors.
Bioorg Med Chem Lett
; 27(13): 2838-2848, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28506751
7.
Corrigendum to "Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors" [Bioorgan. Med. Chem. Lett. 50 (2021) 128352].
Bioorg Med Chem Lett
; 67: 128758, 2022 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35484006
8.
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.
Bioorg Med Chem Lett
; 22(7): 2536-43, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22401863
9.
A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore.
Proc Natl Acad Sci U S A
; 106(6): 1737-42, 2009 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19164768
10.
Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
J Med Chem
; 64(19): 14603-14619, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34596404
11.
Identification of annotated bioactive molecules that impair motility of the blood fluke Schistosoma mansoni.
Int J Parasitol Drugs Drug Resist
; 13: 73-88, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32531750
12.
Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action.
Bioorg Med Chem
; 17(6): 2501-11, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19231206
13.
Discovery of Affinity-Based Probes for Btk Occupancy Assays.
ChemMedChem
; 14(2): 217-223, 2019 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30521698
14.
Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases.
J Med Chem
; 62(17): 7643-7655, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31368705
15.
Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.
Protein Sci
; 17(3): 450-7, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18287278
16.
Structure of a small-molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site.
Protein Sci
; 17(3): 577-82, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18218712
17.
Characterization of substrate binding and catalysis in the potential antibacterial target N-acetylglucosamine-1-phosphate uridyltransferase (GlmU).
Protein Sci
; 16(12): 2657-66, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18029420
18.
Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.
Cancer Discov
; 6(3): 300-15, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26732095
19.
Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.
Cancer Cell
; 28(3): 384-98, 2015 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26343583
20.
Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches.
ACS Chem Biol
; 4(6): 473-83, 2009 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19413326