Detalhe da pesquisa
1.
Diverse alterations associated with resistance to KRAS(G12C) inhibition.
Nature
; 599(7886): 679-683, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34759319
2.
IL-17RA Signaling in Airway Inflammation and Bronchial Hyperreactivity in Allergic Asthma.
Am J Respir Cell Mol Biol
; 53(6): 810-21, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25919006
3.
Synthesis and SAR study of potent and selective PI3Kδ inhibitors.
Bioorg Med Chem Lett
; 25(5): 1104-9, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25666823
4.
A nanoparticle vaccine that targets neoantigen peptides to lymphoid tissues elicits robust antitumor T cell responses.
NPJ Vaccines
; 5(1): 106, 2020 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33298945
5.
Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways.
Front Pharmacol
; 10: 51, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30837866
6.
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
J Med Chem
; 51(6): 1681-94, 2008 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18321037
7.
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
J Med Chem
; 49(16): 4981-91, 2006 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16884310
8.
Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.
J Med Chem
; 49(19): 5671-86, 2006 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16970394
9.
Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors.
J Med Chem
; 59(1): 431-47, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26652588
10.
Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430).
J Med Chem
; 59(15): 7252-67, 2016 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27411843
11.
Mouse embryonic explant culture system for analysis of hematopoietic and vascular development.
Methods Mol Med
; 105: 231-56, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15492399
12.
Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
J Med Chem
; 58(1): 480-511, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25469863
13.
Discovery and in vivo evaluation of dual PI3Kß/δ inhibitors.
J Med Chem
; 55(17): 7667-85, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22876881
14.
Defining dose-response relationships in the therapeutic blockade of B7RP-1-dependent immune responses.
Eur J Pharmacol
; 610(1-3): 110-8, 2009 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-19292985
15.
Efficient gene delivery and gene expression in zebrafish using the Sleeping Beauty transposon.
Dev Biol
; 263(2): 191-202, 2003 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14597195
16.
Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos.
Dev Dyn
; 226(3): 446-59, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12619131