1.
Pain
; 14(3): 279-282, 1982 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7155623
RESUMO
Pretreatment of rats with desipramine (30 mg/kg, s.c.) enhanced both peak intensity and duration of morphine sulfate (5 mg/kg, s.c.) analgesia as determined by measurement of tail flick latency. Morphine concentrations in plasma were also significantly elevated after desipramine. Increased narcotic analgetic responses following desipramine pretreatment appear related to higher circulating levels of unmetabolized morphine.