Detalhe da pesquisa
1.
Engineered interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMR.
J Biol Chem
; 300(5): 107251, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38569939
2.
Synthetic receptor platform to identify loss-of-function single nucleotide variants and designed mutants in the death receptor Fas/CD95.
J Biol Chem
; 299(8): 104989, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37392849
3.
Bispecific soluble cytokine receptor-nanobody fusions inhibit Interleukin (IL-)6 trans-signaling and IL-12/23 or tumor necrosis factor (TNF) signaling.
J Biol Chem
; 299(11): 105343, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37838173
4.
Respiratory syncytial virus-approved mAb Palivizumab as ligand for anti-idiotype nanobody-based synthetic cytokine receptors.
J Biol Chem
; 299(11): 105270, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37734558
5.
A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans-Signaling and Cellular Infection with SARS-CoV-2.
J Virol
; 96(4): e0162221, 2022 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34935434
6.
Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rß1 and subsequent signal transduction.
J Biol Chem
; 297(5): 101295, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34637790
7.
Immunoreceptor Engineering and Synthetic Cytokine Signaling for Therapeutics.
Trends Immunol
; 40(3): 258-272, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30738638
8.
Deciphering site 3 interactions of interleukin 12 and interleukin 23 with their cognate murine and human receptors.
J Biol Chem
; 295(30): 10478-10492, 2020 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32518162
9.
Current status and relevance of single nucleotide polymorphisms in IL-6-/IL-12-type cytokine receptors.
Cytokine
; 148: 155550, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34217594
10.
IL-6 Trans-signaling Controls Liver Regeneration After Partial Hepatectomy.
Hepatology
; 70(6): 2075-2091, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31100194
11.
The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling.
J Biol Chem
; 293(18): 6762-6775, 2018 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29559558
12.
Titin-Based Cardiac Myocyte Stiffening Contributes to Early Adaptive Ventricular Remodeling After Myocardial Infarction.
Circ Res
; 119(9): 1017-1029, 2016 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27650557
13.
Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor ß1 via site II and induces p19/interleukin 23 receptor interaction via site III.
J Biol Chem
; 290(1): 359-70, 2015 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25371211
14.
Alternative intronic polyadenylation generates the interleukin-6 trans-signaling inhibitor sgp130-E10.
J Biol Chem
; 289(32): 22140-50, 2014 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24973212
15.
Rho-kinase: regulation, (dys)function, and inhibition.
Biol Chem
; 394(11): 1399-410, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23950574
16.
Targeting IL-6 trans-signalling: past, present and future prospects.
Nat Rev Immunol
; 23(10): 666-681, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37069261
17.
Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes.
Commun Biol
; 6(1): 418, 2023 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37061565
18.
Exclusive inhibition of IL-6 trans-signaling by soluble gp130FlyRFc.
Cytokine X
; 3(4): 100058, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34927050
19.
Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits TH17 cell expansion.
Sci Signal
; 14(696)2021 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34404751
20.
IL-12 and IL-23-Close Relatives with Structural Homologies but Distinct Immunological Functions.
Cells
; 9(10)2020 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32998371