Detalhe da pesquisa
1.
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
Nature
; 537(7619): 229-233, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27501246
2.
Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.
PLoS Pathog
; 11(7): e1005058, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26186534
3.
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease.
Antimicrob Agents Chemother
; 59(10): 6385-94, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26239982
4.
The nuclear receptor LXR is a glucose sensor.
Nature
; 445(7124): 219-23, 2007 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17187055
5.
Doll Therapy Intervention Reduces Challenging Behaviours of Women with Dementia Living in Nursing Homes: Results from a Randomized Single-Blind Controlled Trial.
J Clin Med
; 11(21)2022 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36362489
6.
Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.
Chem Rev
; 114(22): 11305-47, 2014 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25365529
7.
Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors.
ACS Med Chem Lett
; 12(12): 1912-1919, 2021 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34917254
8.
Doll therapy intervention for women with dementia living in nursing homes: a randomized single-blind controlled trial protocol.
Trials
; 21(1): 133, 2020 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32014029
9.
Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis.
Trop Med Infect Dis
; 5(1)2020 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32079320
10.
Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma.
ACS Med Chem Lett
; 11(4): 558-565, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292564
11.
A Dual Inhibitor of DYRK1A and GSK3ß for ß-Cell Proliferation: Aminopyrazine Derivative GNF4877.
ChemMedChem
; 15(16): 1562-1570, 2020 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32613743
12.
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.
J Med Chem
; 63(8): 3868-3880, 2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31940200
13.
Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
J Med Chem
; 63(19): 10773-10781, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32667203
14.
Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.
J Med Chem
; 63(6): 2958-2973, 2020 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32077280
15.
One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp2-Sp3 Cross-Coupling.
Org Lett
; 21(3): 816-820, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30673257
16.
Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents.
Hepatol Commun
; 3(8): 1085-1097, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-31388629
17.
Generation and Cross-Coupling of Organozinc Reagents in Flow.
Org Lett
; 20(23): 7429-7432, 2018 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30427201
18.
N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.
J Med Chem
; 50(17): 4255-9, 2007 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-17665897
19.
Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).
J Med Chem
; 60(24): 9960-9973, 2017 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29148806
20.
Optimization of Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for Duration of Action, as an Inhaled Therapy for Lung Remodeling in Pulmonary Arterial Hypertension.
J Med Chem
; 59(17): 7901-14, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27502700