RESUMO
BACKGROUND: Toxic optic neuropathies are alterations of the optic nerve and can be caused by environmental, pharmacological, or nutritional agents. CASE: It is about a 7-year-old male patient, a native of the State of Mexico, Mexico who was diagnosed with cervical mycobacterial lymphadenitis that required management with linezolid. OBSERVATIONS: After 7 months of treatment, visual acuity of the left eye decreased and was accompanied by headache. Neuroinfection and other central nervous system affections were discarded. An adverse effect related to treatment with linezolid was suspected, and linezolid was suspended. The symptoms subsided after discontinuation; however, the patient continued to show decreased visual acuity of the left eye, assessed by his ability to count 2 fingers. The right eye remained unaffected. CONCLUSIONS: Neurotoxicity can be decreased by reducing the total dose of linezolid or by administrating it in an intermittent form. To avoid progression and loss of vision, we suggest frequent periodic ophthalmological evaluation in patients treated with linezolid.
Assuntos
Antibacterianos/efeitos adversos , Linezolida/efeitos adversos , Linfadenite/tratamento farmacológico , Linfadenite/microbiologia , Infecções por Mycobacterium não Tuberculosas/tratamento farmacológico , Infecções por Mycobacterium não Tuberculosas/microbiologia , Doenças do Nervo Óptico/induzido quimicamente , Criança , Humanos , Masculino , Micobactérias não Tuberculosas , Acuidade VisualRESUMO
Actualmente existen 430 inmunodeficiencias primarias (IDP) también denominadas errores innatos de la inmunidad, resultado de más de 320 mutaciones identificadas, que en conjunto afectan al menos a 1 de cada 500 recién nacidos vivos, por lo que ya no son consideradas como enfermedades raras. Muchos médicos no sospechan estas patologías, lo cual genera retraso en el diagnóstico y tratamiento, generando un mal pronóstico de calidad de vida y muerte; por lo cual el objetivo de este artículo es transmitir los puntos clave para su sospecha y referencia a un centro de atención especializado. (AU)
Currently there are 430 primary immunodeficiencies (PIDs) also called innate immunity errors, resulting from more than 320 identified mutations, which together affect at least 1 in 500 live newborns and are therefore no longer considered rare diseases. Many doctors do not suspect these pathologies, which generates delay in diagnosis and treatment, generating a poor prognosis for life quality and death, for which reason the objective of this article is to transmit the key points for their suspicion and reference to a specialized center.