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1.
Nat Commun ; 11(1): 3065, 2020 06 11.
Artigo em Inglês | MEDLINE | ID: mdl-32528103

RESUMO

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

2.
Nat Commun ; 10(1): 5187, 2019 11 26.
Artigo em Inglês | MEDLINE | ID: mdl-31772157

RESUMO

Maladaptive reward memories (MRMs) are involved in the development and maintenance of acquired overconsumption disorders, such as harmful alcohol and drug use. The process of memory reconsolidation - where stored memories become briefly labile upon retrieval - may offer a means to disrupt MRMs and prevent relapse. However, reliable means for pharmacologically weakening MRMs in humans remain elusive. Here we demonstrate that the N-methyl D-aspartate (NMDA) antagonist ketamine is able to disrupt MRMs in hazardous drinkers when administered immediately after their retrieval. MRM retrieval + ketamine (RET + KET) effectively reduced the reinforcing effects of alcohol and long-term drinking levels, compared to ketamine or retrieval alone. Blood concentrations of ketamine and its metabolites during the critical 'reconsolidation window' predicted beneficial changes only following MRM reactivation. Pharmacological reconsolidation interference may provide a means to rapidly rewrite maladaptive memory and should be further pursued in alcohol and drug use disorders.


Assuntos
Consumo de Bebidas Alcoólicas/prevenção & controle , Consumo de Bebidas Alcoólicas/psicologia , Ketamina/farmacologia , Adaptação Psicológica , Adulto , Biomarcadores/sangue , Feminino , Humanos , Ketamina/análogos & derivados , Ketamina/sangue , Masculino , Memória/efeitos dos fármacos , Reforço Psicológico , Resultado do Tratamento
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