Detalhe da pesquisa
1.
Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry.
J Biol Chem
; 300(1): 105464, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37979917
2.
Dynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase.
J Biol Chem
; 299(2): 102856, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36596358
3.
Hsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase.
Mol Pharmacol
; 98(3): 243-249, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32591478
4.
Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90ß in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery.
Mol Pharmacol
; 94(3): 984-991, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941666
5.
Improved method for assembly of hemeprotein neuronal NO-synthase heterodimers.
Anal Biochem
; 511: 24-6, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27487179
6.
Architecture of the nitric-oxide synthase holoenzyme reveals large conformational changes and a calmodulin-driven release of the FMN domain.
J Biol Chem
; 289(24): 16855-65, 2014 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24737326
7.
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.
Nat Chem Biol
; 9(2): 112-8, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23222885
8.
Destabilization of the epidermal growth factor receptor (EGFR) by a peptide that inhibits EGFR binding to heat shock protein 90 and receptor dimerization.
J Biol Chem
; 288(37): 26879-86, 2013 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23897823
9.
Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination.
J Biol Chem
; 287(2): 1556-65, 2012 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22128174
10.
Ubiquitination of neuronal nitric-oxide synthase in the calmodulin-binding site triggers proteasomal degradation of the protein.
J Biol Chem
; 287(51): 42601-10, 2012 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23109339
11.
Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft.
Biochemistry
; 50(33): 7146-56, 2011 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21755988
12.
Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.
J Biol Chem
; 285(21): 15714-23, 2010 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20348093
13.
C331A mutant of neuronal nitric-oxide synthase is labilized for Hsp70/CHIP (C terminus of HSC70-interacting protein)-dependent ubiquitination.
J Biol Chem
; 285(44): 33642-51, 2010 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-20729196
14.
Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry.
Biophys Chem
; 274: 106590, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33894563
15.
CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins.
Hum Mol Genet
; 17(24): 3942-52, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18784277
16.
Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts.
Clin Cancer Res
; 26(19): 5246-5257, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32718999
17.
Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination.
Biochemistry
; 48(35): 8483-90, 2009 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19642705
18.
Role of molecular chaperones in steroid receptor action.
Essays Biochem
; 40: 41-58, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15242338
19.
Modulation of ornithine decarboxylase activity and mitogen-activated protein kinases in protocatechualdehyde-induced apoptosis of CTLL-2 cells.
Anticancer Res
; 22(6A): 3389-94, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12530092
20.
A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases.
Exp Biol Med (Maywood)
; 239(11): 1405-13, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24990484