Detalhe da pesquisa
1.
RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation.
Mol Cell
; 82(22): 4262-4276.e5, 2022 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36347258
2.
Regulation of GTPase function by autophosphorylation.
Mol Cell
; 82(5): 950-968.e14, 2022 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35202574
3.
Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling.
Mol Cell
; 76(6): 872-884.e5, 2019 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31606273
4.
Regulation of RAF family kinases: new insights from recent structural and biochemical studies.
Biochem Soc Trans
; 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38695730
5.
Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit.
Mol Cell
; 64(5): 875-887, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27889448
6.
Tolypocladamides A-G: Cytotoxic Peptaibols from Tolypocladium inflatum.
J Nat Prod
; 85(6): 1603-1616, 2022 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35696348
7.
M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell-cell adhesion during collective cell migration.
Proc Natl Acad Sci U S A
; 116(9): 3536-3545, 2019 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30808747
8.
Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling.
Mol Cell
; 49(4): 751-8, 2013 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23352452
9.
Advancing RAS/RASopathy therapies: An NCI-sponsored intramural and extramural collaboration for the study of RASopathies.
Am J Med Genet A
; 182(4): 866-876, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31913576
10.
Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge Theonella swinhoei That Inhibit Ras/Raf Interaction.
J Nat Prod
; 83(4): 1288-1294, 2020 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32191460
11.
LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.
Mol Cell
; 48(2): 298-312, 2012 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22981863
12.
Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy.
Genes Dev
; 26(7): 641-50, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22474259
13.
Targeting the Raf kinases in human cancer: the Raf dimer dilemma.
Br J Cancer
; 118(1): 3-8, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29235562
14.
Macrophilones from the Marine Hydroid Macrorhynchia philippina Can Inhibit ERK Cascade Signaling.
J Nat Prod
; 81(7): 1666-1672, 2018 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29979591
15.
The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling.
Genes Dev
; 24(14): 1496-506, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20634316
16.
Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma.
J Biol Chem
; 291(34): 17804-15, 2016 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226552
17.
KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals.
Mol Cell
; 34(6): 652-62, 2009 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19560418
18.
EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun N-terminal kinase (JNK) activation.
J Biol Chem
; 289(26): 18556-68, 2014 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24825906
19.
14-3-3 Proteins: diverse functions in cell proliferation and cancer progression.
Semin Cell Dev Biol
; 22(7): 681-7, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21884813
20.
RAS signaling: Divide and conquer.
Nat Chem Biol
; 13(1): 7-8, 2016 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27984577