Modulation of elicited behavior by a fixed-interval schedule of electric shock presentation.

Responding elicited in the squirrel monkey by electric shocks presented every 60 seconds was gradually altered in temporal patterning, especially when the shock was also produced by responses under a 30-second fixed-interval schedule. The initially elicited pattern of maximal responding just after each shock was altered by the recurrent shock and by the added fixed-interval schedule to a pattern of maximal responding just before each shock. Most shocks were produced by responses and the response pattern was maintained for several months, but little responding occurred when shocks were omitted.

Pharmacological studies of behavioral influences on cardiovascular function.

Squirrel monkeys, prepared with chronic arterial and venous catheters, responded (pressed a key) under fixed-ratio schedules of termination of a stimulus associated with electric shock or under fixed-ratio schedules of food presentation. Although there was no necessary correlation between schedule-controlled responding and cardiovascular changes, pronounced elevations in both heart rate and blood pressure occurred during and just after brief periods of fixed-ratio responding. These episodic increases in blood pressure and heart rate were as marked under schedules of food presentation as under schedules of stimulus-shock termination. Thus, these episodic changes appear to be more dependent upon the schedule-controlled behavior than upon the type of event maintaining the behavior. Pharmacological studies indicated that under the conditions of the behavioral experiments the squirrel monkey has a relatively high degree of cardiac sympathetic tone; however, blood pressure elevations produced by administration of 1-norepinephrine were associated with an increased parasympathetic tone and decreased heart rate. The reflex bradycardia induced by 1-norepinephrine was inhibited during periods of schedule-controlled responding, suggesting that environmental and behavioral factors can not only modulate the parameters of physiological variables but also modulate this basic cardiovascular control system.

Behavioral effects of chronically administered cocaine in squirrel monkeys.

Cocaine (0.1 or 0.3 mg/kg/h) was infused continuously from osmotic minipumps during 14-day periods in three squirrel monkeys trained under a fixed-interval schedule of stimulus-shock termination. Chronic exposure to 0.1 mg/kg/h cocaine increased response rates during control sessions for two subjects, and rates returned to pre-infusion levels after the osmotic minipumps were removed. During chronic administration with 0.3 mg/kg/h cocaine, tolerance developed to the gross behavioral effects observed initially in all subjects and to the rate-suppressing effects observed in one subject. Using a cumulative-dosing procedure, cocaine was administered IV acutely once per week before, during and after each chronic administration with cocaine. The acute effects of cocaine on schedule-controlled responding before chronic administration and during chronic exposure to 0.1 and 0.3 mg/kg/h cocaine were similar, providing no evidence of sensitization or tolerance.

Glucose feeding and exercise in trained rats: mechanisms for glycogen sparing.

This investigation studied the effect of an oral glucose feeding on glycogen sparing during exercise in non-glycogen-depleted and glycogen-depleted endurance-trained rats. The non-glycogen-depleted rats received via a stomach tube 2 ml of a 20% glucose solution labeled with [U-14C]glucose just prior to exercise (1 h at 25 m/min). Another group of rats ran for 40 min at higher intensity to deplete glycogen stores, after which they received the same glucose feeding and continued running for 1 h at 25 m/min. The initial 40-min run depleted glycogen in heart, skeletal muscle, and liver. In the non-glycogen-depleted rats the glucose feeding spared glycogen in the liver, primarily from the oxidation of blood-borne glucose in muscle. In the glycogen-depleted rats, muscle glycogen was repleted after the feeding, but sources other than the administered glucose also contributed to glycogen synthesis. The results suggest that glycogen depletion rather than the glucose feeding per se stimulates glycogen resynthesis in muscle during exercise in endurance-trained rats.

Influence of exercise training on maternal and fetal morphological characteristics in the rat.

Evidence in both humans and animals has shown that exercise before or during pregnancy may effect fetal outcome. The purpose of this investigation was to examine the effects of an exercise program on fetal development in the rat. Prior to impregnation one group of animals was exercise-trained on a Quinton shock-stimulus rodent treadmill. The exercised group was trained to run 5 days/wk, for 2.0 h/day at 31 m/min up an 8 degree incline for 8 wk before mating. Following mating the training intensity was reduced to 27 m/min up a 5 degree incline, and the exercise period decreased to 1 h/day. On day 19 of gestation, 24 h postexercise for the trained mothers, the animals were killed in the fed state and the maternal and fetal characteristics were measured. The sedentary controls gained significantly (P less than 0.05) more body weight during pregnancy. This can be attributed to three factors: higher number of fetuses, 14.83 +/- 0.04 vs. 12.2 +/- 0.85 for the trained; larger litter weights, 44.25 +/- 4.97 vs. 26.17 +/- 1.82 g/dam for the trained; and slightly larger lipid stores. In addition to having fewer pups the trained mothers had a greater number of fetal resorptions; 0.9/dam as opposed to 0.17/dam for the sedentary control. Analysis of fetal body composition showed no difference in total body water, protein, or fat between the pups of sedentary and trained dams. The results of this study indicate that exercise training prior to and during pregnancy influences fetal development in the rat.

Mothers' compliance with physicians' recommendations on infant feeding.

One hundred thirty-one mothers who were patients of ten physicians were surveyed to determine their compliance with physician-recommended infant feeding practices. For a direct, self-reported measure, the rate of non-compliance was nearly 30 per cent. A second measure, a "compliance score," was computed by comparing mothers' responses to specific questions about the feeding of their babies with their physcians' recommendations for normal, healthy infants. The mean noncompliance rate on this measure was 44 per cent. Differing response patterns regarding specific feeding practices were found for breast-feeding and bottle feeding mothers. To determine selected psychologic factors associated with compliance, health-related attitude and belief scales were originated and validated. Attitudes that "nutrition is important" and a "concern for health" were significantly correlated with the compliance score for breast-feeding mothers.

Combination of buspirone and other drugs with beta-CCE in monkeys: effects on respiration and behavior.

The respiratory and behavioral effects of the benzodiazepine receptor (BZR) inverse agonist ethyl-beta-carboline-3-carboxylate (beta-CCE) were determined alone and in combination with buspirone, lorazepam, flumazenil, and SR 95195 in rhesus monkeys. For the respiratory studies, one group of monkeys inhaled either air or 5% CO2 mixed in air according to a fixed alternating schedule; respiratory frequency and minute volume were monitored. For the behavioral studies, another group of monkeys responded under a fixed-ratio (FR 30) schedule of food presentation. The respiratory stimulant effects of beta-CCE in both air and 5% CO2 were enhanced by prior treatment with the 5-hydroxytryptamine1A (5-HT1A) partial agonist buspirone (0.03 and 0.3 mg/kg) and a weak BZR inverse agonist, SR 95195 (10.0 mg/kg). Coadministration of buspirone (0.1 and 0.3 mg/kg) also potentiated the rate-decreasing effects of beta-CCE under the FR schedule. The BZR agonist lorazepam (3.0 mg/kg) and BZR antagonist flumazenil (1.0 mg/kg) attenuated the effects of beta-CCE on respiratory frequency and minute volume particularly under the 5% CO2 condition, and lorazepam (0.1 and 0.3 mg/kg) and flumazenil (0.1 and 0.3 mg/kg) attenuated the effects of beta-CCE on FR responding. These latter results show that the respiratory and behavioral effects of beta-CCE in rhesus monkeys are at least in part due to effects at BZRs. Moreover, the findings suggest either that coactivation of benzodiazepine and 5-HT1A sites lead to a greater than additive effect or that beta-CCE and buspirone share a common mechanism of action that is unrelated to the receptor at which BZR inverse agonists act.

Schedules using noxious stimuli. IV: An interlocking shock-postponement schedule in the squirrel monkey.

Responding was studied under various schedules of electric shock postponement and presentatation in the squirrel monkey. Under an interlocking shock-postponement schedule, successive responses decreased the time by which a response postponed the next scheduled shock until a shock immediately followed the nth response. Some parameters of this schedule, which can be formally related to fixed-interval schedules, engendered a pattern of positively accelerated responding between shocks. This pattern did not occur under comparable parameter values of an alternative fixed-ratio, avoidance schedule under which each response postponed shock by a fixed duration and every nth response produced shock. Subsequently, performances were studied under schedules of shock presentation. Responding was never maintained under fixed-ratio schedules of shock presentation, but was maintained with a pattern of positive acceleration under an alternative fixed-ratio, fixed-interval schedule and under a fixed-interval schedule.

Schedules using noxious stimuli. II: low intensity electric shock as a discriminative stimulus.

The presence or absence of pulses of low intensity electric shock was used as a discriminative stimulus to control responding under fixed ratio reinforcement in the squirrel monkey. Initially brief periods of nonreinforcement were lengthened only when discriminative control was evident. Discriminative control was studied by (1) varying the duration of nonreinforcement periods; (2) reversing the stimulus conditions correlated with reinforcement and nonreinforcement periods; and (3) determining the minimum shock intensity necessary to maintain discriminative control. Stimulus control was not reliably affected by d-amphetamine, chlorpromazine, or morphine. The discriminative control by pulses of low intensity electric shock was similar to that by other discriminative stimuli, except that the control developed slowly and was better when the pulsing shock was correlated with reinforcement than when correlated with nonreinforcement.

Schedules using noxious stimuli. III. Responding maintained with response-produced electric shocks.

Responding was maintained in two squirrel monkeys under several variations of a 10-min fixed-interval schedule of electric shock presentation. The monkeys were first trained under a 2-min variable-interval schedule of food presentation, and then under a concurrent schedule of food presentation and shock presentation. In one monkey, when shocks (12.6 ma) followed each response during the last minute of an 11-min cycle ending with a timeout period, responding was increased during the first 10 min and suppressed during the last minute of each cycle. When the shock schedule was eliminated, both the enhancement and suppression disappeared, and a steady rate of responding was maintained under the variable-interval schedule. When the food schedule was eliminated, the shock schedule maintained a characteristic fixed-interval pattern of responding during the first 10 min, but suppressed responding during the last minute of each cycle. The fixed-interval pattern of responding was maintained when the timeout period was eliminated and when only one shock could occur at the end of the cycle. In the second monkey, responding under the concurrent food and shock schedule was suppressed when responses produced shocks after 3-min. Under an 11-min cycle, responding continued to be maintained at increasing shock intensities. When the food schedule was eliminated, a fixed-interval pattern of responding was maintained under a 10-min schedule of shock presentation (12.6 ma). Whether response-produced electric shocks suppressed responding or maintained responding depended on the schedule of shock presentation.

Schedules using noxious stimuli. I. Multiple fixed-ratio and fixed-interval termination of schedule complexes.

The termination of a schedule complex, comprising a stimulus in the presence of which brief presentations of electric shocks are scheduled, is a reinforcer. Conditions were studied under which schedule-controlled patterns of responding characteristic of fixed-interval, fixed-ratio, and multiple fixed-interval fixed-ratio schedules can be maintained in the squirrel monkey by terminating a schedule complex. The schedule of shock presentation was a critical determinant of the patterns of responding, especially under fixed-interval schedules of termination. The rates and patterns of responding under various schedules of termination of schedule complexes were generally akin to those maintained under comparable schedules of food presentation. The findings suggest a general similarity in the dynamic aspects of performances under schedules of schedule-complex termination and comparable schedules of food presentation. The schedule of reinforcement is more important than the nature of the reinforcer in the control of behavior.

Operant conditioning in the newly hatched chicken.

Techniques are described for conditioning key-pecking reinforced with food and for recording cheeping in newly hatched chickens. A mirror in the test box is essential when conditioning isolated chickens up to five or more days old. Conditioning proceeds more rapidly when frequently pecked objects and materials that move when scratched are not present. Stimulus control over key-pecking is present in the three-day-old chicken and multiple fixed-ratio, fixed-interval schedule control develops in succeeding days. In young chickens, pecking and cheeping are inversely related. The newly hatched chicken is useful for pharmacological studies and appears to offer other advantages for behavioral studies.

The effect of sodium trimetaphosphate (TMP) as a chewing gum additive on caries increments in children.

A three-year study on school-age children using trimetaphosphate as a chewing gum additive produced significant reductions in proximal surface dental caries increments as compared to an non-chewing gum group. The reductions were 23.3% for the TMP sucrose gum group and 47.6% for the TMP nonsugar group as compared to the no-gum group.

A process model to guide selection of essential curriculum content.

The purpose of this qualitative study was to develop and test the usefulness of a process model to identify guidelines for selecting essential content in undergraduate nursing curricula from nursing and related disciplines. The study was designed to test the usefulness of the model. Usefulness was determined by evaluating the operationalization of the model and the product resulting from operationalization of the model. The criteria of practicality, purposiveness, realism, and judiciousness were used. The model consists of four steps. In Step 1, the content area is delineated. Step 2 consists of a review of the literature of both disciplines. Analysis and synthesis of this information results in guidelines, stated in conceptual terms and accompanied by brief rationale, for essential content. In Step 3, educators and clinicians are interviewed to determine reliability and validity of the guidelines. In Step 4, guidelines are revised based on comments obtained in Step 3. Operationalization of the model using nutrition content resulted in five content and three process guidelines. Both the process described by the model and the guidelines which resulted from that process were evaluated as useful. Suggestions for future research using the model are made.

Connecting the research and nursing processes: making a difference in baccalaureate students' attitudes and abilities.

Student nurses are often intimidated by the research process. They also frequently have negative attitudes about working with the elderly, especially in long-term care settings. This article describes a clinical project designed to help students improve their attitudes, knowledge, and skills toward research and care of the elderly by connecting the research process and the nursing process. Students implement research-based clinical practice in a long-term care setting. Student evaluations indicate that project goals are achieved. Nursing staff evaluation data indicate that they find student projects interesting and useful in updating resident care plans.

Liberal and professional undergraduate nursing education: maintaining the connections.

Current recommendations to improve undergraduate education range from increasing the proportion of general education credits to removing professional preparation from undergraduate education. The authors argue for the necessity of integrating general education and professional preparation throughout all levels of higher education. A conceptual framework to study professional preparation developed by Stark et al. is presented. Methods to integrate both general education and professional preparation are analyzed, and specific implications for nursing are discussed.

Activity anorexia: An interplay between basic and applied behavior analysis.

The relationship between basic research with nonhumans and applied behavior analysis is illustrated by our work on activity anorexia. When rats are fed one meal a day and allowed to run on an activity wheel, they run excessively, stop eating, and die of starvation. Convergent evidence, from several different research areas, indicates that the behavior of these animals and humans who self-starve is functionally similar. A biobehavioral theory of activity anorexia is presented that details the cultural contingencies, behavioral processes, and physiology of anorexia. Diagnostic criteria and a three-stage treatment program for activity-based anorexia are outlined. The animal model permits basic research on anorexia that for practical and ethical reasons cannot be conducted with humans. Thus, basic research can have applied importance.