Prospective multicenter study of pregnancy outcomes in women with heart disease.

BACKGROUND: The maternal and neonatal risks associated with pregnancy in women with heart disease receiving comprehensive prenatal care have not been well defined. METHODS AND RESULTS: We prospectively enrolled 562 consecutive pregnant women with heart disease and determined the outcomes of 599 pregnancies not ending in miscarriage. Pulmonary edema, arrhythmia, stroke, or cardiac death complicated 13% of pregnancies. Prior cardiac events or arrhythmia, poor functional class or cyanosis, left heart obstruction, and left ventricular systolic dysfunction independently predicted maternal cardiac complications; the cardiac event rate can be predicted using a risk index incorporating these predictors. Neonatal complications (20% of pregnancies) were associated with poor functional class or cyanosis, left heart obstruction, anticoagulation, smoking, and multiple gestations. CONCLUSIONS: Pregnancy in women with heart disease is associated with significant cardiac and neonatal complications, despite state-of-the-art obstetric and cardiac care. Maternal cardiac risk can be predicted with the use of a risk index.

Intravenous dipyridamole-induced myocardial ischemia during percutaneous transluminal coronary angioplasty in humans.

Percutaneous transluminal coronary angioplasty was used as a model of controlled myocardial ischemia to study the effect of intravenous dipyridamole on myocardial ischemia and coronary hemodynamics in 10 patients. All patients had 1-vessel coronary artery disease with visualized collaterals. Intravenous dipyridamole increased myocardial ischemia during inflations. ST elevation, as measured by intracoronary electrogram, increased significantly from the control inflation to the second inflation after dipyridamole injection (0.05 +/- 0.23 vs 0.44 +/- 0.43 mV, p less than 0.03). Of the 10 patients, 8 developed new or more severe angina with subsequent inflations after dipyridamole. The pulmonary artery wedge pressure increased significantly from the control inflation to the fourth inflation (15 +/- 8 vs 20 +/- 9 mm Hg, p less than 0.05). The coronary wedge pressure showed a decreasing trend with subsequent inflations after dipyridamole but did not reach statistical significance. The double product (heart rate X blood pressure) was not significantly altered by dipyridamole. The findings indicate that intravenous dipyridamole increases myocardial ischemia during balloon occlusion. The constancy of the double product and the trend toward a decrease in coronary wedge pressure suggest that dipyridamole may induce ischemia by reducing the amount of collateral flow through a coronary steal phenomenon.

Serum CK-MB activity during and after aortocoronary bypass surgery.

Frequent serum sampling of CK-MB and total CK levels was carried out in 100 patients during and up to 48 hours following aortocoronary bypass surgery. Using an ion exchange chromatography method for CK-MB determination, significantly higher serum CK-MB levels (peak 46.1 +/- 5.2 cf. 31.3 +/- 2.2 u/L), but not total CK levels were present 6 to 16 hours postoperatively in those with new Q waves in the ECG. Serum levels of CK-MB in those patients with uncomplicated surgery were defined. New post-operative Q waves were seen in only one half of cases with frankly abnormal CK-MB curves and seriously underestimated the incidence of perioperative infarction. Peak levels of CK-MB in patients with new Q waves occurred within 16 hours of surgery suggesting that infarction is usually an intraoperative or early post-operative event.

The choice of contrast agents in the cardiac catheterization laboratory.

The availability of newer and more expensive low osmolar contrast agents for cardiac angiography has forced a comparison with the standard ionic contrast agents. The milder hemodynamic effects of low osmolar agents make them the contrast of choice for the sickest patients; however, the existence of a reduction in the rate of anaphylactoid reactions or death during catheterization seems more doubtful. Guidelines for the selective use of the agents in the cardiac catheterization laboratory are offered, based on one hospital's experience of more than 20,000 procedures.

Primary repair of Fallot's tetralogy in an older adult: a 20-year follow-up.

A patient with tetralogy of Fallot who presented at 58 years of age is described. Following surgical intracardiac repair he had 20 years of improved functional capacity. Though such surgery is now usually performed in infancy, the literature indicates that surgical correction of tetralogy of Fallot in appropriate adults is associated with low mortality and good long-term results.

Improvement of ventricular function after atrioventricular junction ablation in a patient with atrial flutter after Mustard's operation.

Arrhythmias are common problems following Mustard's operation for D-transposition of the great arteries. A 19-year-old male is presented who was diagnosed at birth with D-transposition of the great arteries and a right aortic arch and underwent a Mustard procedure at 12 months of age. He developed sinus node dysfunction and atrial flutter unresponsive to antiarrhythmic drugs and dual chamber pacing. Following complete heart block with radiofrequency catheter ablation of the atrioventricular junction, the patient's heart was paced in VVIR mode. Ventricular function improved after the ablation and persisted in two years' follow-up.

Torsade de pointes with amiodarone in a patient with previous torsade during beta-receptor blockade.

Torsade de pointes is a potentially lethal ventricular arrhythmia that is associated with prolonged QT intervals and is often caused by drugs that prolong repolarization. Among the most common drugs that may cause torsade de pointes are antiarrhythmic drugs including quinidine, procainamide, sotalol and newer class III antiarrhythmic agents. The incidence of torsade de pointes associated with amiodarone, however, is reported to be much lower. A case is reported of amiodarone-induced torsade de pointes following the development of the same arrhythmia during beta-blocker use. This case illustrates that although the reported incidence of torsade de pointes during amiodarone therapy is low, patients with bradycardia-induced torsade de pointes may be a subgroup of patients who are at increased risk of this arrhythmia with amiodarone.

Late reassessment of percutaneous transluminal coronary angioplasty results: clinical, exercise and angiographic follow-up.

One hundred and forty-five patients underwent percutaneous transluminal coronary angioplasty (PTCA) in the authors' hospital between 1981 and 1983. Four have since died and all but one of the remainder were accounted for at follow-up 41 +/- 12 months later. Recurrence of angina was present in 28% of patients having successful PTCA versus 33% of patients with surgery for failed PTCA. Use of antianginal drugs and return to work was similar in the two groups. Mean treadmill time, peak heart rate, incidence of treadmill angina and exercise thallium-201 defects were not different in the two groups. Late follow-up coronary angiography in 60 patients who had successful PTCA showed a significant decrease in mean stenosis of the dilated segment from 31 to 23%. Of 25 patients who had late angiography after failed PTCA, three had satisfactory patency of the dilated segment. New significant coronary stenosis was seen in only 17% of patients not having coronary bypass surgery.

Local morphologic effects of coronary artery balloon angioplasty.

The morphologic effects of percutaneous transluminal coronary artery balloon angioplasty (PTCA) on atherosclerotic vessels is described in six patients who died at varying intervals after the procedure (four early and two late). In the early group (less than one week post PTCA) one patient died because of electromechanical dissociation during emergency PTCA for evolving infarct; in the three other patients PTCA was performed for left main occlusion and cardiogenic shock with deaths 3, 24 and 25 h after PTCA. The two late deaths were patients who died one and nine months after PTCA from unrelated causes. There were 12 sites of balloon inflation in the six patients, all in left main, isolated marginal or left anterior descending arteries. Post mortem examinations, with in toto serial sectioning of the ballooned coronary arteries, revealed a number of local morphologic changes. Plaque fractures and disruptions of the arterial wall to variable depths were observed. At four sites these fractures were through media, and at one site was associated with a large dissection. These cases had only small epicardial hemorrhages or reactive adventitial changes associated with these deep fractures. Four of the six patients had intramural arterial emboli (athero/thrombo/calcium/foreign body). These findings confirm that a large part of the effect of PTCA is due to physical disruption of plaque and underlying native vessel.

Basic equipment requirements for hemodynamic monitoring.

Hemodynamic monitoring in the critically ill patient requires the use of sophisticated electronic devices. To use this equipment one should have a general understanding of the principles involved and the requirements of a reliable system. This communication serves to explain the requirements of the various components of a hemodynamic monitoring system and to demonstrate how they interact to produce accurate and safe electronic signals from mechanical wave forms obtained from the patient.

Natural history and management of chronic aortic valve disease.

Chronic aortic valve disease involving stenosis, regurgitation or both is insidious and progressive. Severe valvular dysfunction may be present for years without symptoms, but functional deterioration is often rapid once congestive heart failure, angina or syncope with effort is present. As the severity of aortic stenosis may not be easy to assess clinically, the relative usefulness of various tests is considered in this paper. The difficulty with chronic aortic regurgitation lies not in diagnosing the problem but in detecting early left ventricular dysfunction in time to perform the surgery that can prevent further functional deterioration. Patients with significant aortic valve disease should undergo surgery when the important symptoms of dyspnea, angina or syncope with effort first appear. Surgery should also be considered in selected patients with aortic regurgitation in whom left ventricular function has diminished even without symptoms.

A computer graphic-based angiographic model for normal left ventricular contraction in man and its application to the detection of abnormalities in regional wall motion.

Analyzing the digitized left ventricular cineangiograms of 70 patients with no demonstrable heart disease (NDHD), we derived an angiographic model for normal contraction in the intact heart as viewed in the 30 degree right anterior oblique projection. This model was verified statistically by comparing the predicted regional stroke volumes with the measured volumes for the NDHD group. A wall motion system based on this model was compared with four other systems by examining the ventriculograms of 141 patients, all suffering from coronary artery disease but with normal volumes and ejection fractions (greater than 0.61). Of these, 60 had normally contracting ventricles and 81 exhibited mild regional abnormalities according to two experienced angiographers. Using Cochrane's Q test, we found significant differences among the five methods (Q = 29.5;p less than .001). The new approach showed significantly better agreement with the subjective assessment than the next best method (Q = 5.3;p less than .05). On a regional basis, overall sensitivity was 87.5% and specificity was 97.9%.

Complications of cardiac catheterization: one centre's experience.

Data on complication rates in a cardiac catheterization laboratory were prospectively gathered over a 6-year period. During this time 7960 catheterizations were performed. Death occurred in seven (0.1%) of the cases. The difference between the mortality rates for procedures performed with and without systemically administered heparin (0.04% and 0.2% respectively) was barely statistically significant (p less than 0.05). A significant complication occurred in 1.5% of the cases; however, most did not have long-term sequelae. No significant change in the annual rate of such complications was seen during the study period. Such a tabulation permits audit of quality of care, points out changing trends in morbidity and offers meaningful information on the safety of cardiac catheterization to referring physicians and their patients.

Death in a catheterization laboratory.

OBJECTIVE: To assess current rates of death from diagnostic and therapeutic cardiac catheterization as well as changes in the rates, if any, from 1977 to 1991. DESIGN: A prospective descriptive study. SETTING: Catheterization laboratory, University of Ottawa Heart Institute. PATIENTS: Consecutive patients undergoing diagnostic and therapeutic procedures from 1977 to 1991. Those undergoing endomyocardial biopsy or electrophysiologic study were excluded. INTERVENTIONS: Cardiac catheterization with angiography, percutaneous transluminal coronary angioplasty (PTCA) or valvuloplasty. MAIN OUTCOME MEASURES: Rates of death within 24 hours after the procedure or later if causally related to the procedure. RESULTS: There were 32 deaths attributed to 30,838 diagnostic catheterization procedures, for a rate of 0.10%. The rate did not change significantly during the study period. Most (24 [75%]) of the 32 deaths were related to coronary angiography; all but one of these patients had left main-stem artery or triple-vessel disease. None of the cases of anaphylactoid reaction to the contrast medium resulted in death. Death from PTCA was largely confined to patients with unstable coronary syndromes, including postinfarction shock. The rate of death from elective PTCA was approximately 0.1%. CONCLUSIONS: The death rate in our catheterization laboratory has remained the same since 1977, despite changes in the patient population. Patients at highest risk of death from angiography are those with unstable and global myocardial ischemia. The universal use of low-osmolar contrast medium is not justified given the absence of fatal anaphylactoid reactions. The risk of death from elective PTCA is low, and patients at highest risk have unstable coronary artery syndromes.

Safety and criteria for selective use of low-osmolality contrast for cardiac angiography.

OBJECTIVES: Recommendations to restrict low-osmolality contrast to high-risk patients having cardiac angiography have been challenged because of safety and uncertainty about selection criteria. The authors document frequency and severity of adverse events with diagnostic cardiac angiography under the influence of guidelines for selective use of low-osmolality contrast in high-risk patients and refine high-risk criteria. METHODS: Subjects of this prospective cohort study were 7,448 unselected patients having diagnostic cardiac angiography in St. John's, Newfoundland or Ottawa, Ontario. Measures included prespecified risk factors, procedure, contrast, and adverse events such as death within 24 hours, myocardial infarction, stroke, arrhythmias, hypotension, and anaphylactoid reactions. RESULTS: Patients were similar at both sites. Fourteen point two percent received low-osmolality nonionic agents in St. John's. Thirty-four point one percent received low-osmolality (mostly ionic) media in Ottawa. Overall adverse event rates were similar at both sites: death, 0.07%; myocardial infarction or stroke, 0.03%; moderate events, 2%; and mild events, 16.8%. Event rates were low in those given high-osmolality media: death, 0.02%; myocardial infarction or stroke, 0.24%; moderate events, 1.6%; and mild events, 18%. The risk with cardiogenic shock and prior severe reaction to contrast could not be examined, but otherwise only current heart failure and markers of recent ischemia were associated with events after high-osmolality media. CONCLUSIONS: Clinicians, using guidelines, can identify high-risk patients and should be able to safely limit use of low-osmolality media to them.

Left ventricular outflow obstruction at multiple levels: occurrence in a single patient.

Combined forms of left ventricular outflow obstruction are being recognized with increasing frequency. A patient who had coarctation of the aorta, valvular aortic stenosis, and fixed and dynamic subvalvular obstruction is described. The importance of recognizing multiple levels of obstruction in such patients is emphasized.

Myocardial infarction in coronary artery surgery.

Myocardial infarction has been noted as a frequent complication of coronary artery surgery in many review series, although its causes are uncertain. Follow-up of 100 patients at 19.7 months (mean) after coronary bypass surgery identified 15 patients with perioperative myocardial infarction as judged by new, significant Q waves after surgery. There were no significnat differences in age, preoperative anginal class, previous infarction, presence of hypertension, hyperlipidemia, or frank glucose intolerance compared with the 85 patients without infarction. Nor was there a significnat difference in coronary artery score, left ventricular end-diastolic pressure, cardiac index, or presence of collaterals. Cardiopulmonary bypass time, duration of anoxic arrest, and number of vessels grafted did not differ. Perioperative infarction always occurred in the territory of a grafted vessel and not in comparably compromised, nongrafted areas. In 13 cases new Q waves appeared in the first 24 hours, and myocardial infarction was not clinically suspected. Eight of the 15 grafts at risk were patent at late follow-up. Mean ejection fraction was not significantly changed postoperatively, but affected segmental wall motion declined in most cases. Five patients with perioperative infarction but no patent grafts improved by only 1 NYHA class (mean), but ten patients with infarction and one or more grafts patent improved by 2.9 NYHA classes (mean). Perioperative infarction could not be correlated with currently recognized patient and operative risk factors. The consistent anatomical relationship suggested that the grafting procedure itself was critical to the occurrence of distal segmental infarction.

Fate of the graft and native vessel following endarterectomy of the left anterior descending coronary artery.

In 16 patients who underwent endarterectomy of the left anterior descending (LAD) coronary artery combined with saphenous vein bypass grafting between Aug. 1, 1976 and July 31, 1978, the results of preoperative and postoperative angiography were comparable. Most patients had obstruction or severe stenosis of the proximal LAD coronary artery together with a poor runoff as demonstrated angiographically. Eighteen vein grafts were placed in the LAD artery and 15 (83%) were satisfactorily patent. Six of 18 grafted arterial segments became occluded distal to the site of graft insertion, but in most cases there was sufficient proximal runoff to maintain graft patency. In this study intraoperative measurements of graft flow were predictive of graft or distal vessel patency, or both. Careful postoperative assessment of the results of this technique seems warranted.

Long-term angiographic assessment of the influence of coronary risk factors on native coronary circulation and saphenous vein aortocoronary grafts.

The influence of smoking, hyperlipidemia, and glucose intolerance on graft patency and rate of progression of obstructive disease in the native circulation was assessed in 99 patients 1 1/2 years after aortocoronary bypass grafting. There were 24 patients in whom none of these risk factors was identified. There were 42 patients with one, 29 with two, and four with three risk factors. Overall graft patency rate was 74%. Graft patency was not significantly influenced by any of these factors either singly or in combination. Progression of obstructive disease in both proximal and distal segments of grafted vessels and in nongrafted vessels was not significantly increased by the presence of one, two, or three risk factors. Over all, there was progression in 56% of segments proximal to grafts, in 8% distal to grafts, and in 14% of nongrafted vessels. Longer term studies will be required to establish any adverse influence of these risk factors on saphenous vein bypass grafts and native circulation.

Progression of coronary disease in candidates for transluminal coronary angioplasty.

Five of our first 20 candidates for PTCA had unanticipated occlusion of the relevant coronary artery between the time of coronary angiography and PTCA. None had a change in symptoms or ECG to suggest coronary occlusion. We currently schedule PTCA within a month to help avoid this occurrence.