Detalhe da pesquisa
1.
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548400
2.
Cholesterol-dependent cytolysins: The outstanding questions.
IUBMB Life
; 74(12): 1169-1179, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35836358
3.
A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1.
Proc Natl Acad Sci U S A
; 116(28): 13943-13951, 2019 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31221747
4.
Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome.
J Allergy Clin Immunol
; 148(2): 585-598, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33771552
5.
The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement.
J Biol Chem
; 295(24): 8285-8301, 2020 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32332100
6.
Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation.
Chem Rev
; 119(13): 7721-7736, 2019 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31244002
7.
Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals.
Angew Chem Int Ed Engl
; 58(47): 16780-16784, 2019 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31385643
8.
Protein structure and computational drug discovery.
Biochem Soc Trans
; 46(5): 1367-1379, 2018 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30242117
9.
An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin.
Proc Natl Acad Sci U S A
; 112(7): 2204-9, 2015 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25646411
10.
Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 12): 2386-95, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26627647
11.
The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1.
Bioorg Med Chem Lett
; 25(4): 969-75, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25595682
12.
1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: identification of BTA9881 as a preclinical candidate.
Bioorg Med Chem Lett
; 25(4): 976-81, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25595685
13.
Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents.
Bioorg Med Chem Lett
; 24(21): 4984-8, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288185
14.
Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors.
Bioorg Med Chem Lett
; 24(17): 4215-22, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25086682
15.
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Nat Commun
; 15(1): 937, 2024 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38297033
16.
Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant.
Nat Commun
; 14(1): 7543, 2023 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37985757
17.
A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein.
EMBO Mol Med
; 15(1): e16236, 2023 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36468184
18.
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Res Sq
; 2023 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37546892
19.
Single-molecule analysis of the entire perfringolysin O pore formation pathway.
Elife
; 112022 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36000711
20.
Heparin Inhibits SARS-CoV-2 Replication in Human Nasal Epithelial Cells.
Viruses
; 14(12)2022 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36560624