Detalhe da pesquisa
1.
Development of Anti-CD74 Antibody-Drug Conjugates to Target Glucocorticoids to Immune Cells.
Bioconjug Chem
; 29(7): 2357-2369, 2018 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29923706
2.
Potent benzoazepinone γ-secretase modulators with improved bioavailability.
Bioorg Med Chem Lett
; 25(17): 3495-500, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26142947
3.
Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aß42 lowering in rodents and rhesus monkeys.
Bioorg Med Chem Lett
; 25(17): 3488-94, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26212776
4.
Etanercept ameliorates inflammation and pain in a novel mono-arthritic multi-flare model of streptococcal cell wall induced arthritis.
BMC Musculoskelet Disord
; 15: 409, 2014 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25477192
5.
Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma.
Cancer Res
; 84(9): 1410-1425, 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38335304
6.
Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction.
Am J Respir Cell Mol Biol
; 49(6): 1085-92, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23889698
7.
Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.
J Med Chem
; 66(21): 14912-14927, 2023 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37861679
8.
A bioluminescence reporter mouse model for visualizing and quantifying CD8+ T cells in vivo.
Neoplasia
; 27: 100781, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35381456
9.
Ileocolonic-Targeted JAK Inhibitor: A Safer and More Effective Treatment for Inflammatory Bowel Disease.
Pharmaceutics
; 14(11)2022 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36365202
10.
Reverse Translating Molecular Determinants of Anti-Programmed Death 1 Immunotherapy Response in Mouse Syngeneic Tumor Models.
Mol Cancer Ther
; 21(3): 427-439, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34965960
11.
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
J Med Chem
; 65(24): 16801-16817, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475697
12.
Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool.
Neuron
; 56(1): 79-93, 2007 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17920017
13.
Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology.
Proc Natl Acad Sci U S A
; 105(47): 18561-6, 2008 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19017804
14.
Purine derivatives as potent gamma-secretase modulators.
Bioorg Med Chem Lett
; 20(7): 2279-82, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207146
15.
Cancer-Associated Fibroblasts Promote Immunosuppression by Inducing ROS-Generating Monocytic MDSCs in Lung Squamous Cell Carcinoma.
Cancer Immunol Res
; 8(4): 436-450, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32075803
16.
Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases.
ACS Med Chem Lett
; 11(2): 114-119, 2020 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32071676
17.
p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.
J Neurosci
; 26(41): 10536-41, 2006 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17035538
18.
Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.
ACS Med Chem Lett
; 6(6): 683-8, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26101574
19.
Development and optimization of a high-throughput micro-computed tomography imaging method incorporating a novel analysis technique to evaluate bone mineral density of arthritic joints in a rodent model of collagen induced arthritis.
Bone
; 73: 32-41, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25482211
20.
Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors.
J Med Chem
; 58(4): 1929-39, 2015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25625541