Detalhe da pesquisa
1.
Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.
Bioorg Med Chem Lett
; 27(6): 1478-1483, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28190634
2.
A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose.
J Med Chem
; 60(13): 5933-5939, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28613895
3.
Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective.
Drug Discov Today
; 22(10): 1447-1459, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28476536
4.
Use of Osmotic Pumps to Establish the Pharmacokinetic-Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors.
J Med Chem
; 59(12): 5810-22, 2016 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27194201
5.
Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.
ACS Med Chem Lett
; 7(9): 857-61, 2016 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27660691
6.
Preclinical pharmacokinetic/pharmacodynamic modeling and simulation in the pharmaceutical industry: an IQ consortium survey examining the current landscape.
AAPS J
; 17(2): 462-73, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25630504
7.
Discovery of a novel series of orally active nociceptin/orphanin FQ (NOP) receptor antagonists based on a dihydrospiro(piperidine-4,7'-thieno[2,3-c]pyran) scaffold.
J Med Chem
; 57(8): 3418-29, 2014 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24678969
8.
Development of LC-MS/MS-based receptor occupancy tracers and positron emission tomography radioligands for the nociceptin/orphanin FQ (NOP) receptor.
J Med Chem
; 55(11): 4955-67, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22541041
9.
In silico, in vitro and in situ models to assess interplay between CYP3A and P-gp.
Curr Drug Metab
; 12(8): 750-73, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21568936
10.
Absorption barriers in the rat intestinal mucosa: 1. Application of an in situ perfusion model to simultaneously assess drug permeation and metabolism.
J Pharm Sci
; 99(2): 982-98, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19746412
11.
Absorption barriers in the rat intestinal mucosa. 3: Effects of polyethoxylated solubilizing agents on drug permeation and metabolism.
J Pharm Sci
; 99(2): 1016-27, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19650119
12.
Absorption barriers in the rat intestinal mucosa: 2. Application of physiologically based mathematical models to quantify mechanisms of drug permeation and metabolism.
J Pharm Sci
; 99(2): 999-1015, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19798765
13.
Analysis of CYP mRNA expression by branched DNA technology.
Methods Enzymol
; 357: 170-9, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12424908
14.
The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice.
Toxicol Appl Pharmacol
; 214(2): 178-87, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16542693
15.
The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes.
Toxicol Appl Pharmacol
; 199(3): 193-209, 2004 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15364537
16.
Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.
Drug Metab Dispos
; 31(4): 421-31, 2003 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-12642468