Detalhe da pesquisa
1.
Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models.
Neurobiol Dis
; 159: 105492, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34478849
2.
Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates.
Neurobiol Dis
; 155: 105385, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33991647
3.
Delayed administration of the human anti-RGMa monoclonal antibody elezanumab promotes functional recovery including spontaneous voiding after spinal cord injury in rats.
Neurobiol Dis
; 143: 104995, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32590037
4.
Levodopa increases oxidative stress and repulsive guidance molecule A levels: a pilot study in patients with Parkinson's disease.
J Neural Transm (Vienna)
; 123(4): 401-6, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26880022
5.
Quantification of Hepcidin-related Iron Accumulation in the Rat Liver.
Toxicol Pathol
; 44(2): 259-66, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26839325
6.
Decreased levels of repulsive guidance molecule A in association with beneficial effects of repeated intrathecal triamcinolone acetonide application in progressive multiple sclerosis patients.
J Neural Transm (Vienna)
; 122(6): 841-8, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25209051
7.
Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis.
Glia
; 62(2): 217-32, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24311453
8.
The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity.
Nat Commun
; 15(1): 1037, 2024 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38310100
9.
Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels.
Haematologica
; 101(5): e173-6, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26944476
10.
RGM and its receptor neogenin regulate neuronal survival.
Nat Cell Biol
; 6(8): 749-55, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15258591
11.
Neogenin mediates the action of repulsive guidance molecule.
Nat Cell Biol
; 6(8): 756-62, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15258590
12.
RGMa inhibition promotes axonal growth and recovery after spinal cord injury.
J Cell Biol
; 173(1): 47-58, 2006 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16585268
13.
Neogenin and repulsive guidance molecule signaling in the central nervous system.
Curr Opin Neurobiol
; 17(1): 29-34, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17169551
14.
LIM-only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin.
J Neurochem
; 107(2): 418-31, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18702663
15.
Myosin IIA is required for neurite outgrowth inhibition produced by repulsive guidance molecule.
J Neurochem
; 105(1): 113-26, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18005226
16.
Purkinje cell survival in organotypic cultures: implication of Rho and its downstream effector ROCK.
J Neurosci Res
; 86(3): 531-6, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17893923
17.
Rho kinase, a promising drug target for neurological disorders.
Nat Rev Drug Discov
; 4(5): 387-98, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15864268
18.
Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design.
J Med Chem
; 61(24): 11074-11100, 2018 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30384606
19.
RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling.
Trends Cell Biol
; 27(5): 365-378, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28007423
20.
RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury.
Sci Rep
; 7(1): 10529, 2017 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28874746