Detalhe da pesquisa
1.
Introduction of C-alkyl branches to L-iminosugars changes their active site binding orientation.
Org Biomol Chem
; 20(36): 7250-7260, 2022 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35838176
2.
Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia.
Molecules
; 27(10)2022 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35630818
3.
Borylated 2,3,4,5-Tetrachlorophthalimide and Their 2,3,4,5-Tetrachlorobenzamide Analogues: Synthesis, Their Glycosidase Inhibition and Anticancer Properties in View to Boron Neutron Capture Therapy.
Molecules
; 27(11)2022 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35684388
4.
Synthesis of (+)-(R)-Tiruchanduramine.
Molecules
; 27(4)2022 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35209136
5.
Garcinia kola and garcinoic acid suppress SARS-CoV-2 spike glycoprotein S1-induced hyper-inflammation in human PBMCs through inhibition of NF-κB activation.
Phytother Res
; 35(12): 6963-6973, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34697842
6.
Strategy for Designing Selective Lysosomal Acid α-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity.
Molecules
; 25(12)2020 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32575625
7.
Isolation from Stevia rebaudiana of DMDP acetic acid, a novel iminosugar amino acid: synthesis and glycosidase inhibition profile of glycine and ß-alanine pyrrolidine amino acids.
Amino Acids
; 51(7): 991-998, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31079215
8.
Ginnalin B induces differentiation markers and modulates the proliferation/differentiation balance via the upregulation of NOTCH1 in human epidermal keratinocytes.
Bioorg Med Chem
; 27(11): 2172-2180, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31005366
9.
In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease.
Org Biomol Chem
; 15(44): 9297-9304, 2017 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28959811
10.
Strategy for designing selective α-l-rhamnosidase inhibitors: Synthesis and biological evaluation of l-DMDP cyclic isothioureas.
Bioorg Med Chem
; 25(1): 107-115, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27789075
11.
Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease.
Org Biomol Chem
; 14(3): 1039-48, 2016 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26633162
12.
Design and Synthesis of Labystegines, Hybrid Iminosugars from LAB and Calystegine, as Inhibitors of Intestinal α-Glucosidases: Binding Conformation and Interaction for ntSI.
J Org Chem
; 80(9): 4501-15, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25843107
13.
Nine of 16 stereoisomeric polyhydroxylated proline amides are potent ß-N-acetylhexosaminidase inhibitors.
J Org Chem
; 79(8): 3398-409, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24641544
14.
Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease.
Bioorg Med Chem
; 22(8): 2435-41, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24657053
15.
Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities.
Org Biomol Chem
; 11(23): 3826-33, 2013 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23640519
16.
Design and Pharmacological Chaperone Effects of N-(4'-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase.
J Med Chem
; 66(13): 9023-9039, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37314161
17.
The role of alpha-glucosidase in germinating barley grains.
Plant Physiol
; 155(2): 932-43, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21098673
18.
Stereoselective synthesis and biological evaluation of D-fagomine, D-3-epi-fagomine and D-3,4-epi-fagomine analogs from D-glyceraldehyde acetonide as a common building block.
Org Biomol Chem
; 10(46): 9278-86, 2012 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23104470
19.
N-(2-Carb-oxy-eth-yl)-2,5-dide-oxy-2,5-imino-d-mannonic acid [(3R,4R,5R)-1-(2-carb-oxy-eth-yl)-3,4-dihy-droxy-5-hy-droxy-methyl-l-proline].
Acta Crystallogr Sect E Struct Rep Online
; 68(Pt 10): o2865-6, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23125666
20.
Isolation and Characterisation of Quercitrin as a Potent Anti-Sickle Cell Anaemia Agent from Alchornea cordifolia.
J Clin Med
; 11(8)2022 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35456270