Detalhe da pesquisa
1.
Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists.
Bioorg Med Chem Lett
; 29(16): 2265-2269, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31257087
2.
Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.
Bioorg Med Chem Lett
; 27(4): 855-861, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28108251
3.
Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors.
Bioorg Med Chem Lett
; 26(17): 4256-60, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27476421
4.
Pseudosaccharin amines as potent and selective KV1.5 blockers.
Bioorg Med Chem Lett
; 25(21): 4983-4986, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25801931
5.
Chemical and enzymatic reductive activation of acylfulvene to isomeric cytotoxic reactive intermediates.
Chem Res Toxicol
; 24(11): 2044-54, 2011 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21939268
6.
PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.
ACS Med Chem Lett
; 9(7): 673-678, 2018 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30034599
7.
Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.
J Med Chem
; 60(12): 5193-5208, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28541707
8.
Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity.
J Med Chem
; 49(8): 2593-9, 2006 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16610802
9.
Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I Kur Inhibitor.
ACS Med Chem Lett
; 7(9): 831-4, 2016 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27660686
10.
Quantitative correlation of drug bioactivation and deoxyadenosine alkylation by acylfulvene.
Chem Res Toxicol
; 20(10): 1513-9, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17900171