Correlation of pre-morbid alcoholism and changes in the level of biogenic amine metabolites in cerebrospinal fluid of accute brain infarction patients.

BACKGROUND: The disorder of biogenic amine metabolism (serotonin - 5-HT and dopamine - DA) is expected in the brain (neuron) damage caused by acute ischemia. It is known that long-term abuse of ethyl-alcohol damages the quality of neurons diffusely in the brain. Cerebrospinal fluid (CSF) and its biochemical content, 5-HT and DA, are reliable indicators of the vitality of neurons. The main objective of this research was to demonstrate that the elevated content of metabolites 5-HT and DA in the CSF in patients with acute brain infarction, who were pre-morbid alcohol-dependent patients, is additionally emphasized by diffusive damage of neuron vitality caused by alcoholism. SUBJECTS AND METHODS: Study sample consists of two groups - 50 alcohol-dependent patients with acute brain infarction under the age of 65 (group A) and 50 patients with acute brain infarction who were not alcohol-dependent (group B). All subjects underwent the same procedure - CSF was taken during admission to the hospital and history was obtained through anamnesis, heteroanamnesis and clinical examinations. RESULTS: Metabolism of DA and metabolic turnover of DA (3, 4 dihydroxyphenylacetic acid + homovanilic acid; DOPAC + HVA) was elevated in the liquor of both patient groups. The statistically significant difference between the groups was found in metabolic turnover of 5-HT (p<0.05), and metabolic turnover of DA (p<0.001). CONCLUSIONS: The metabolic neuron disbalance, i.e. their pathophysiological-biochemical dysfunction as a result of acute brain infarction, is present in a higher degree in patients with pre-morbid long-term alcohol abuse.

Anxiety in epileptic patients.

BACKGROUND: Anxiety may occur as ictal, postictal or interictal symptom in patients with epilepsy. The main aim of this research was to explore the intensity and frequency of anxiety in patients with generalized, temporal and extratemporal epilepsy. SUBJECTS AND METHODS: This is a cross-sectional study of three groups of patients with epilepsy (30 patients per group) - recently diagnosed with generalized epilepsy, temporal epilepsy and extratemporal epilepsy, and a healthy control group (N=30). The Beck Anxiety Inventory (BAI) was used for quantitative assessment of anxiety. RESULTS: Patients with temporal and extratemporal epilepsies had a significantly higher mean total scores on the BAI than the patients with generalized forms of epilepsies (ANOVA: F=6.323, p<0.01). There were no statistically significant differences between the temporal and extratemporal epilepsy groups according to the levels of anxiety on BAI (t-test: t=1.68, p>0.05). For the first three symptoms - numbness, wobbling in the legs and the fear of the worst happening - the group of patients with extratemporal epilepsies had significantly higher average levels of intensity and frequency of symptoms (ANOVA: F1=5.591, F2=6.555, F3=5.906; p<0.01) CONCLUSIONS: Patients with partial epilepsy have more frequent and prominent anxiety symptoms than patients with generalized epilepsy, and also more than the control group. All these findings clearly indicate the necessity to modify treatment strategies accordingly in order to include both the antiepileptic therapy and treatment for anxiety disorders.

Analysis of quality of life and anxiety in patients with different forms of epilepsy.

BACKGROUND: Anxiety symptoms may have significant implications on the quality of life of patients with epilepsy. The aim of our research is a comparative analysis of the quality of life, i.e., of the level of disability in patients with different forms of epilepsy. METHOD: In this cross-sectional study, the sample consisted of three groups of 30 patients each--with recently diagnosed generalized epilepsy, temporal and extratemporal epilepsy. the anxiety level in these groups was compared with the control group of 30 healthy subjects. Beck anxiety inventory (Bai) was used for assessment of anxiety. level of functional disability due to anxiety was measured according to the Sheehan Disability Scale (SDS). RESULTS: Patients with extratemporal epilepsy had the greatest level of functional disability, while patients with generalized epilepsies had the lowest average of scores on the Sheehan scale. the correlation between the Bai and the SDS was highly statistically significant. CONCLUSIONS: Our results clearly indicate the need for a broader concept of therapy--neurological (antiepileptic therapy) and psychiatric (pharmaco-, psycho- and social therapy) when it comes to anxiety in patients with epilepsy.

[Dysfunctionality of the primary family as a supportive factor for the development of polytoxicomany in young people].

INTRODUCTION: Dependent behaviour represents a strong homeostasis of the family of an addict. OBJECTIVE: The aim of our research is to record and explore irregularities during the addicts' growth, as well as the specific type of family relations in the addicts' family. METHODS: For research purposes a general questionnaire was used on growth and development, and GRADIR questionnaire on the assessment of family relationships. RESULTS: Our results indicate that delinquent behaviour is often found with the addicts before the occurrence of abuse. A significant dysfunctional family of addicts was detected. Families with an addict were not substantially damaged or altered in terms of emotional exchange, but in their structure that enhanced dysfunction leading to addictive behaviour. CONCLUSION: Emotional investments without control, prohibitions and penalties, contribute to a lack of consciousness that disturbs the process of socialization. Due to the apparent control and the apparent support, the addicts do not have structured organization and socialization. Emotional stimuli without obligation for polytoxicomanes to maintain a reciprocal relationship with their parents influence the parental support of egoistic style of behaviour.

[Professional stress in general practitioners and psychiatrists--the level of psycologic distress and burnout risk].

BACKGROUND/AIM: So far, studies of stress have shown that physicians are at a high risk of sickness from psychic and somatic disorders related to professional stress, that can lead to important disturbance of personal, familiar and professional functionating. The aim of this study was to investigate the doctors exposition level to professional stress, to compare stress level in general practitioners (GP) group with that in the group of psychiatrists and risk level for the apperance of burnout syndrome. METHODS: This cross-section study included subjects recruited by a random sample method. Thirty General Practice doctors and 30 psychiatrists (totally 60 doctors) filled the set of 3 questionnaires: Sociodemographics features, General Health Questionnaire (GHQ; Goldberg D, 1991), and Maslach Burnout Inventory (MBI; Maslach C, 1996). Appropriate statistical procedures (Pearson test, t-test, variance analysis) in interpretation of the results were used. RESULTS: A total level of psychic distress measured with the GHQ test in both groups of physicians was very low implying their good mental health. A difference in Burnout risk based on MBI test between the groups was statistically significant (chi2 = 4,286; p < 0.05) only at subscale Personal Accomplishment (MBI-PA); it was a consequence of a higher number of GPs with medium burnout risk (13.3 : 0.0%). However, even 35 physicians from the sample were affected with a high burnout risk measured with subscales Emotional Ehausation (MBI-EE) and MBI-DP, showing that both groups of physicians had risk for the appearance of burnout syndrome. CONCLUSION: The obtained results showed a high burnout risk level in both, GPs and psychiatrists, groups. In both groups there was no presence of psychic disorders (anxiety, depression, insomnia), while there was a high level of emotional ehausation and overtension by job, and also a lower total personal accomplishment. Level of exposition to professional stress is higher in GPs than in psychiatrists, but the difference was not statistically significant.