RESUMO
In experiment on the model of mechanical acute ileus (AI) in accordance to morphological and microbiological investigations data there was established, that in intestinal wall, situated above the obstacle place, purulent enteritis occurs, what may constitute the origin of purulent-septic complications after elimination of the Al cause. Application of antibacterial preparations permits to slow down the progression of destructive processes in the affected intestinal wall.
Assuntos
Antibacterianos/farmacologia , Ileíte/tratamento farmacológico , Íleo/efeitos dos fármacos , Íleus/tratamento farmacológico , Ampicilina/farmacologia , Animais , Bactérias/efeitos dos fármacos , Bactérias/crescimento & desenvolvimento , Bactérias/isolamento & purificação , Ceftriaxona/farmacologia , Ciprofloxacina/análogos & derivados , Fluoroquinolonas/farmacologia , Gentamicinas/farmacologia , Ileíte/microbiologia , Ileíte/patologia , Íleo/microbiologia , Íleo/patologia , Íleus/microbiologia , Íleus/patologia , Injeções Intramusculares , Testes de Sensibilidade Microbiana , Ratos , Ratos WistarRESUMO
In experiment, while simulating an acute ileus, the possibility of antibacterial preparations for prophylaxis of purulent--septic complications was studied. There was established, that while progressing purulent intestinal inflammation its wall already in 12 h losses a capacity to cumulate penicillines and aminoglycosides. In a phlegmon-like changed intestine during 48 h cephalosporins and fluorochinolons are accumulated in bactericidal concentration, making a destruction of intestinal wall and occurrence of purulent peritonitis by 6-12 h slower.