Detalhe da pesquisa
1.
First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers.
Mov Disord
; 32(2): 211-218, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27886407
2.
A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data.
Front Neurol
; 12: 705407, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34659081
3.
Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti-α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease: A Randomized Clinical Trial.
JAMA Neurol
; 75(10): 1206-1214, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29913017
4.
Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.
J Neurosci
; 25(3): 629-36, 2005 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15659599
5.
Analysis of rodent growth data in toxicology studies.
Toxicol Sci
; 66(2): 313-9, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11896298
6.
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-ß over Notch.
J Med Chem
; 56(13): 5261-74, 2013 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23713656
7.
Quantitative assessment of cumulative carcinogenic risk for multiple genotoxic impurities in a new drug substance.
Regul Toxicol Pharmacol
; 51(3): 270-7, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18550240
8.
A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity.
Regul Toxicol Pharmacol
; 44(3): 198-211, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16412543