Detalhe da pesquisa
1.
Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles.
Nat Chem Biol
; 16(5): 497-506, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32231343
2.
Discovery of the potent non-steroidal glucocorticoid receptor modulator BAY 1003803 as clinical candidate.
Bioorg Med Chem Lett
; 30(16): 127298, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32631518
3.
BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.
Int J Cancer
; 140(2): 449-459, 2017 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27699769
4.
Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.
Acta Neuropathol
; 133(4): 629-644, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28124097
5.
Identification of novel GLUT inhibitors.
Bioorg Med Chem Lett
; 26(7): 1732-7, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26949183
6.
Optimization of allosteric MEK inhibitors. Part 2: Taming the sulfamide group balances compound distribution properties.
Bioorg Med Chem Lett
; 26(1): 186-93, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26611920
7.
Optimization of allosteric MEK inhibitors. Part 1: Venturing into underexplored SAR territories.
Bioorg Med Chem Lett
; 23(8): 2384-90, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23474388
8.
BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe.
J Med Chem
; 65(21): 14366-14390, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36261130
9.
Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase.
J Med Chem
; 63(15): 8025-8042, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32338514
10.
Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance.
Mol Cancer Ther
; 17(11): 2285-2296, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30115664
11.
Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death.
Cell Death Dis
; 8(3): e2709, 2017 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28358364
12.
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
ACS Chem Biol
; 12(8): 1986-1992, 2017 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28679043
13.
Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876.
ChemMedChem
; 11(20): 2261-2271, 2016 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27552707
14.
BAY 1024767 blocks androgen receptor mutants found in castration-resistant prostate cancer patients.
Oncotarget
; 7(5): 6015-28, 2016 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26760770
15.
Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity.
Mol Cancer Ther
; 15(4): 583-92, 2016 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26832791
16.
Novel alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor antagonists of 2,3-benzodiazepine type: chemical synthesis, in vitro characterization, and in vivo prevention of acute neurodegeneration.
J Med Chem
; 48(14): 4618-27, 2005 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-15999999
17.
Modular Assembly of Allosteric MEK Inhibitor Structural Elements Unravels Potency and Feedback-Modulation Handles.
ChemMedChem
; 10(12): 2004-13, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26541480
18.
Allosteric MEK1/2 inhibitor refametinib (BAY 86-9766) in combination with sorafenib exhibits antitumor activity in preclinical murine and rat models of hepatocellular carcinoma.
Neoplasia
; 15(10): 1161-71, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24204195
19.
Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?
Cell Metab
; 23(4): 569-70, 2016 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27076070
20.
Mechanism-based inhibition: deriving K(I) and k(inact) directly from time-dependent IC(50) values.
J Biomol Screen
; 14(8): 913-23, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19675314