Detalhe da pesquisa
1.
Ablation of α2δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo.
Proc Natl Acad Sci U S A
; 115(51): E12043-E12052, 2018 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30487217
2.
A CaV2.1 N-terminal fragment relieves the dominant-negative inhibition by an Episodic ataxia 2 mutant.
Neurobiol Dis
; 93: 243-56, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27260834
3.
α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage.
J Neurosci
; 33(42): 16412-26, 2013 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24133248
4.
The Interplay Between Splicing of Two Exon Combinations Differentially Affects Membrane Targeting and Function of Human CaV2.2.
Function (Oxf)
; 5(1): zqad060, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38020068
5.
The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function.
Proc Natl Acad Sci U S A
; 107(4): 1654-9, 2010 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20080692
6.
Nerve injury increases native Ca V 2.2 trafficking in dorsal root ganglion mechanoreceptors.
Pain
; 164(6): 1264-1279, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36524581
7.
N terminus is key to the dominant negative suppression of Ca(V)2 calcium channels: implications for episodic ataxia type 2.
J Biol Chem
; 285(2): 835-44, 2010 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19903821
8.
Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin.
Proc Natl Acad Sci U S A
; 105(9): 3628-33, 2008 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18299583
9.
The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin.
J Neurosci
; 29(13): 4076-88, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19339603
10.
The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression.
J Neurosci
; 26(48): 12576-86, 2006 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-17135419
11.
LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit.
Sci Rep
; 7: 43802, 2017 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28256585
12.
Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties.
J Neurosci
; 25(30): 6984-96, 2005 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16049174
13.
Effect of knockout of α2δ-1 on action potentials in mouse sensory neurons.
Philos Trans R Soc Lond B Biol Sci
; 371(1700)2016 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27377724
14.
Thrombospondin-4 reduces binding affinity of [(3)H]-gabapentin to calcium-channel α2δ-1-subunit but does not interact with α2δ-1 on the cell-surface when co-expressed.
Sci Rep
; 6: 24531, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27076051
15.
Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels.
Elife
; 52016 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27782881
16.
Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density.
Nat Commun
; 5: 3628, 2014 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24709664
17.
Labelling of the 3D structure of the cardiac L-type voltage-gated calcium channel.
Channels (Austin)
; 3(6): 387-92, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19875947
18.
COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis.
Plant J
; 32(4): 457-66, 2002 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-12445118