Detalhe da pesquisa
1.
Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6.
Biochemistry
; 58(52): 5320-5328, 2019 12 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31095371
2.
ERK5 kinase activity is dispensable for cellular immune response and proliferation.
Proc Natl Acad Sci U S A
; 113(42): 11865-11870, 2016 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27679845
3.
Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma.
Blood
; 128(2): 239-48, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27151888
4.
Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response.
Biochemistry
; 55(38): 5434-41, 2016 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27571378
5.
ATP Acyl Phosphate Reactivity Reveals Native Conformations of Hsp90 Paralogs and Inhibitor Target Engagement.
Biochemistry
; 54(19): 3024-36, 2015 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25905789
6.
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.
Nat Chem Biol
; 7(4): 203-5, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21378983
7.
Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.
J Pharmacol Exp Ther
; 338(1): 114-24, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21505060
8.
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).
Bioorg Med Chem Lett
; 19(10): 2865-9, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19386497
9.
High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.
Commun Biol
; 2: 345, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31552298
10.
Erratum: Author Correction: High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.
Commun Biol
; 2: 438, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31799439
11.
Inhibitor focusing: direct selection of drug targets from proteomes using activity-based probes.
Assay Drug Dev Technol
; 1(1 Pt 2): 137-46, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15090140
12.
Functional interrogation of kinases and other nucleotide-binding proteins.
FEBS Lett
; 587(13): 1870-7, 2013 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23684650
13.
Profiling native kinases by immuno-assisted activity-based profiling.
Curr Protoc Chem Biol
; 5(3): 213-26, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24391084
14.
Discovery of potent and selective covalent inhibitors of JNK.
Chem Biol
; 19(1): 140-54, 2012 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22284361
15.
In situ kinase profiling reveals functionally relevant properties of native kinases.
Chem Biol
; 18(6): 699-710, 2011 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21700206
16.
Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.
ACS Med Chem Lett
; 2(2): 91-96, 2011 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21666860
17.
Functional interrogation of the kinome using nucleotide acyl phosphates.
Biochemistry
; 46(2): 350-8, 2007 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17209545
18.
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.
Biochemistry
; 46(45): 13019-30, 2007 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-17949010
19.
Blocking site-to-site translocation of a misactivated amino acid by mutation of a class I tRNA synthetase.
Proc Natl Acad Sci U S A
; 99(2): 585-90, 2002 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-11782529
20.
Mutational separation of two pathways for editing by a class I tRNA synthetase.
Mol Cell
; 9(2): 353-62, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11864608