Detalhe da pesquisa
1.
NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting.
Nat Immunol
; 21(10): 1267-1279, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32868928
2.
NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts.
Blood
; 141(13): 1584-1596, 2023 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36375120
3.
Self-reactivity on a spectrum: A sliding scale of peripheral B cell tolerance.
Immunol Rev
; 292(1): 37-60, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31631352
4.
Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens.
J Immunol
; 203(2): 418-428, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31167773
5.
Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery.
J Immunol
; 202(10): 2907-2923, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962292
6.
An extracatalytic function of CD45 in B cells is mediated by CD22.
Proc Natl Acad Sci U S A
; 112(47): E6515-24, 2015 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26561584
7.
Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies.
J Med Chem
; 67(4): 2321-2336, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38300987
8.
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Science
; 383(6682): eadi5798, 2024 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38301010
9.
Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance.
Curr Opin Immunol
; 55: 67-74, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30292928
10.
IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.
Elife
; 72018 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29521626
11.
Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells.
Immunohorizons
; 1(9): 188-197, 2017 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29152611