Prevalence of hepatitis B and C infection and linkage to care among patients with Non-Communicable Diseases in three rural Rwandan districts: a retrospective cross-sectional study.

INTRODUCTION: Rwanda's Hepatitis C elimination campaign has relied on mass screening campaigns. An alternative "micro-elimination" strategy focused on specific populations, such as non-communicable disease (NCD) patients, could be a more efficient approach to identifying patients and linking them to care. METHODS: This retrospective cross-sectional study used routine data collected during a targeted screening campaign among NCD patients in Kirehe, Kayonza, and Burera districts of Rwanda and patients receiving oncology services from the Butaro District Hospital. The campaign used rapid diagnostic tests to screen for Hepatitis B surface antigen (HBsAg) and Hepatitis C antibody (anti-HCV). We reported prevalences and 95% confidence intervals for HBsAg and anti-HCV, assessed for associations between patients' clinical programs and hepatitis B and C, and reported cascade of care for the two diseases. RESULTS: Out of 7,603 NCD patients, 3398 (45.9%) self-reported a prior hepatitis screening. Prevalence of HBsAg was 2.0% (95% CI: 1.7%-2.3%) and anti-HCV was 6.7% (95% CI: 6.2%-7.3%). The prevalence of HBsAg was significantly higher among patients < 40 years (2.4%). Increased age was significantly associated with anti-HCV (12.0% among patients ≥ 70 years). Of the 148 individuals who screened positive for HbsAg, 123 had viral load results returned, 101 had detectable viral loads (median viral load: 451 UI/mL), and 12 were linked to care. Of the 507 individuals who screened positive for anti-HCV, 468 had their viral load results returned (median viral load: 1,130,000 UI/mL), 304 had detectable viral loads, and 230 were linked to care. CONCLUSION: Anti-HCV prevalence among Rwandan patients with NCD was high, likely due to their older age. NCD-HCV co-infected patients had high HCV viral loads and may be at risk of poor outcomes from hepatitis C. Hepatitis C micro-elimination campaigns among NCD patients are a feasible and acceptable strategy to enhance case detection in this high-prevalence population with elevated viral loads and may support linkage to care for hepatitis C among elderly populations.

Climate change, culture and health: Indigenous resilience, a study from Turkana County, Kenya.

Climate change and recurring droughts-induced effects on health are becoming an increasingly main global, cultural and public health burden. The heaviest health burden leans on the fragile socio-economic systems among the remote agro-pastoral communities, living in the arid and semi-arid lands (ASALs). Previous studies underlined the indispensability of indigenous knowledge (IK) for resilience-driven disaster risk reduction (DRR) strategies. However, more attention has been drawn towards the necessity of IK in weather forecasts, with less emphasis on its indispensability to alleviate health burden associated with climate change and droughts. We explored the contextual application of IK-based adaptation and related complementarity aspects for culturally relevant and sustainable DRR strategies for the nomadic agro-pastoral communities in Lopur, Turkana, Kenya. Relying on a descriptive qualitative study in phenomenological approach, purposive sampling and focus group discussions with key community influencers, a thematic analysis was conducted for an in-depth understanding and interpretation of data patterns. The contextualised insights revealed the growing vulnerability as a result of the disconnect between modern interventions, IK and the newly adopted environmental degrading coping tactics. Policy-wise, the findings portrayed the necessity for cultural integration and incorporation of indigenous knowledge-based strategies and systems for reinforced information dissemination, accessibility and acceptability for droughts preparedness and response. Contribution: This study underlined the existing room for scientific exploration of the already existing indigenous knowledge-based solutions for food and water insecurity, towards improved resilience for the vulnerable communities experiencing inequitable climate change calamities in the ASALs.

Patterns and disparities in indoor particulate matter levels in selected primary schools in Kigali, Rwanda.

Air pollution is a global environmental and public health challenge. There is limited evidence about the air quality in Rwanda, and the concentrations of particulate matter (PM), namely PM2.5 and PM10 in schools have not been well documented. This study evaluated patterns and disparities in indoor PM levels in selected primary schools in Kigali, Rwanda. The study collected PM2.5 and PM10 concentrations from six classrooms in six selected primary schools during the regular school study period in the dry season. Data were collected using mobile air sensors (purple air/PA-II-SD air quality) and an observation checklist. A Kruskal-Wallis test was performed to assess the difference in PM2.5 and PM10 concentrations between the six schools. The post-hoc Mann-Whitney test was used to compare all group pairs. The results indicated a significant difference in both the indoor PM2.5 concentration (H (5) = 41.01, p < 0.001) and the indoor PM10 concentration (H (5) = 38.5, p < 0.001). The maximum concentration observed was 133.6 µg/m3 for PM2.5 and 158.5 µg/m3 for PM10. Schools in highly exposed areas tended to have higher concentrations of PM than schools in moderately exposed areas. Specifically, the daily average concentration of PM2.5 in schools located in highly exposed areas ranged from 39 µg/m³ to 118 µg/m³, while PM10 levels ranged from 44.0 µg/m³ to 126 µg/m³. In contrast, schools in moderately exposed areas had daily PM2.5 average concentrations ranging from 32.0 µg/m³ to 111.0 µg/m³ and daily PM10 average concentrations ranging from 38.0 µg/m³ to 119 µg/m³. Overall, the recorded values for both PM2.5 and PM10 in all sampled schools were higher than the World Health Organization air quality guidelines. Indoor air quality is poorer in schools situated in highly exposed areas. This study suggests interventions to improve school air quality for the benefit of school communities.

Impact of randomly assigned "pay-as-you-go" liquefied petroleum gas prices on energy use for cooking: Experimental pilot evidence from rural Rwanda.

The disease burden related to air pollution from traditional solid-fuel cooking practices in low- and middle-income countries impacts millions of people globally. Although the use of liquefied petroleum gas (LPG) fuel for cooking can meaningfully reduce household air pollution concentrations, major barriers, including affordability and accessibility, have limited widespread adoption. Using a randomized controlled trial, our objective was to evaluate the association between the cost and use of LPG among 23 rural Rwandan households. We provided a 2-burner LPG stove with accessories and incorporated a "pay-as-you-go" (PAYG) LPG service model that included fuel delivery. PAYG services remove the large up-front cost of cylinder refills by integrating "smart meter" technology that allows participants to pay in incremental amounts, as needed. We assigned three randomized discounted prices for LPG to each household at ~4-week intervals over a 12-week period. We modeled the relationship between randomized PAYG LPG price and use (standardized to monthly periods), analyzing effect modification by relative household wealth. A 1000 Rwandan Franc (about 1 USD at the time of the study) increase in LPG price/kg was associated with a 4.1 kg/month decrease in use (95% confidence interval [CI]: -6.7, -1.6; n=69 observations). Wealth modified this association; we observed a 9.7 kg/month reduction (95% CI: -14.8, -4.5) among wealthier households and a 2.5 kg/month reduction (95% CI: -5.3, 0.3) among lower-wealth households (p-interaction=0.01). The difference in price sensitivity was driven by higher LPG use among wealthier households at more heavily discounted prices; from an 80% to 10% discount, wealthy households used 17.5 to 5.3 kg/month and less wealthy households used 6.2 to 3.1 kg/month. Our pilot-level experimental evidence of PAYG LPG in a rural low-resource setting suggests that further exploration of subsidized pricing varied by household wealth is needed to ensure future policy initiatives can achieve targets without exacerbating inequities.

Exposure to indoor and outdoor air pollution in schools in Africa: Current status, knowledge gaps, and a call to action.

Chronic exposure to indoor and outdoor air pollution is linked to adverse human health impacts worldwide, and in children, these include increased respiratory symptoms, reduced cognitive and academic performance, and absences from school. African children are exposed to high levels of air pollution from aging diesel and gasoline second-hand vehicles, dusty roads, trash burning, and solid-fuel combustion for cooking. There is a need for more empirical evidence on the impact of air pollutants on schoolchildren in most countries of Africa. Therefore, we conducted a scoping review on schoolchildren's exposure to indoor and outdoor PM2.5 (particulate matter with an aerodynamic diameter less than 2.5 µm and PM10 (particulate matter with an aerodynamic diameter less than 10 µm) in Africa. Following PRISMA guidelines, our search strategy yielded 2975 records, of which eight peer-reviewed articles met our selection criteria and were considered in the final analysis. We also analyzed satellite data on PM2.5 and PM10 levels in five African regions from 1990 to 2019 and compared schoolchildren's exposure to PM2.5 and PM10 levels in Africa with available data from the rest of the world. The findings showed that schoolchildren in Africa are frequently exposed to PM2.5 and PM10 levels exceeding the recommended World Health Organization air quality guidelines. We conclude with a list of recommendations and strategies to reduce air pollution exposure in African schools. Education can help to produce citizens who are literate in environmental science and policy. More air quality measurements in schools and intervention studies are needed to protect schoolchildren's health and reduce exposure to air pollution in classrooms across Africa.

Excreta Disgust and Adaptive Use of Ecological Sanitation By-Products: Perspectives of Rural Farmers in Burera District, Rwanda.

Ecological sanitation (Ecosan) by-products are inherently limited in their potential use as excreta resources. Disgust behind human excreta and derivatives continues to challenge the further use of Ecosan-by products. Although treated excreta, including Ecosan by-products, have gradually been adopted worldwide, diverse perspectives among users hinder their use in agro-practices. This study explored perceptions of the use of Ecosan-by products as relates to the disgust of human excreta among rural farmers in Burera district, Rwanda. A qualitative study was conducted amongst three farmers' cooperatives using Ecosan by-products. We conducted six focus group discussions (FDGs) comprising a total of 48 participants taking into account the following three themes: core excreta disgust, perceived waste, and perceived resource. Thematic analysis was conducted with similar perspectives identified and grouped under emerging sub-themes. The perspectives regarding disgust elicitors included stigma, eversion, phobia, taboos, and health risks. Ecosan by-products were largely perceived as useful, with most farmers trusting and willing to touch the by-products. Psychosocial barriers to using the by-products continued to slow down the adoption of Ecosan for agricultural options. There is a need for increased awareness to scale up the use of Ecosan coupled with effective treatment practices for the products so as to reverse the psychological barriers resulting from traditional excreta disgust over Ecosan-products of faeces and urine.

Assessment of prices, availability and affordability of essential medicines in Juba County, South Sudan.

BACKGROUND: Access to safe, effective, affordable, and high-quality medications has been included in the Sustainable Development Goals (SDGs) of the United Nations as a crucial step towards attaining universal health coverage. Access to medicines is a fundamental human right. If medicines are accessible and affordable, they save lives by reducing mortality and morbidity associated with acute and chronic diseases. WHO recommends that all countries voluntarily reach the minimum target of 80% availability of medicines by 2025. The primary purpose of this research is to assess access to essential medicines in Juba County, South Sudan. METHODS: This study was undertaken using the standard World Health Organization/Health Action International Organization (WHO/HAI) approach for surveying the prices, availability, and affordability of medicines. A survey was conducted in six payams of Juba County, South Sudan, and 55 health facilities were assessed. RESULTS: Prices for generic medicines were better in faith-based health facilities with a median price ratio of 1.95. Private pharmacies and private clinics had MPRs of 4.64 and 4.32, respectively. Local prices were high compared to International referent prices. Availability of medicines was highest in the faith-based health facilities (65.5%) and slightly lower in private pharmacies (55.4%), private clinics (57.7%) and public (50.4%) sectors. Most of the surveyed medicines were unaffordable. The medicines needed to treat non-communicable diseases cost up to 33.7-day wages for one full course of treatment. CONCLUSIONS: In South Sudan, medicines are poorly available in all sectors. Medicines are affordable in the public sector but Most medicines are unaffordable in private pharmacies, private clinics and faith-based health facilities. Poor medicines availability in the public sector contributes to the overall unaffordability of medicines in all the other sectors.

Factors Associated With Utilization of Ecological Sanitation Technology in Burera District, Rwanda: A Mixed Methods Research.

Background: The utilization of "on-site excreta decomposition technology" known as "Ecological sanitation (Ecosan)" has a rational use of human excreta. It is a resource-oriented sanitation mostly feasible in areas with rocky soil and prone to agriculture. This technology was implemented in Rwanda for more than a decade. However, little is known about Ecosan utilization in the process of scale-up in the community. Aim: The study was carried out to determine enablers and barriers associated with the utilization of Ecosan in Burera district, Rwanda. Methods: A mixed method study was surveyed in 374 households with Ecosan. A systematic random sampling was used to select respondents and a sample was drawn from the 3 administrative sectors of Burera district. We interviewed 20 key informants that included community leaders and sanitation actors. Bivariate, ordered logistic regression with thematic content analysis were used. Results: Ecosan users were unable to practice both urine diversion and the use of Ecosan by-products. Only 39.4% of households were better users. As by the survey results, primary and secondary educational status (AOR 2.60, 95% CI 1.11-6.08) and (AOR 3.49, 95% CI 1.02-11.9), frequency of fecal pit emptying (AOR 3.38, 95% CI (2.18-17.91), ash use (AOR 1.65, 95% CI (0.93-4.64) and concrete slab latrine (AOR 7.31, 95% CI (2.94-17.95) were found to be associated with better use of Ecosan. Qualitative findings suggested unaffordable cost, a touch of excreta taboos, and poor maintenance practices as key barriers to utilization. Conclusion: Overall utilization of Ecosan was poor and the majority of households was not able to use Ecosan for both dry separation of urine from feces and reuse in the gardens. Upgrading existing knowledge about Ecosan with greater emphasis on the use of by-products and adopting good maintenance practices through regular training can promote better utilization of Ecosan.