Mortality after hip fracture and assessment of some contributory factors.

Of 881 patients with hip fracture operated on in Galway between 1968 and 1973 only 77 per cent were alive after six months from the time of injury, 72 per cent survived 1 year and 63 per cent survived two years. A control sample, sex and age matched, showed survival rates of 96 per cent, 93 per cent and 84 per cent for corresponding periods. After six months the hip fracture appears to have little bearing on survival.Factors having an adverse effect on the outcome were the following in their order of importance: atheroma, bedsores on admission, male sex, concomitant illness and sustaining the injury in the first quarter of the year. A better than average outcome was associated with the absence of these factors or their logical converse. Factors which appear to play an insignificant role in relation to mortality are the type of operation, the length of operation or the accident circumstances except road traffic accidents, which were often in young healthy patients and so gave a better than expected survival. In assessing the influence of these factors on mortality each group was again compared with matched samples from the general population.

Transhiatal oesophagectomy in the management of advanced oesophageal carcinoma.

Thirty-seven patients have undergone transhiatal oesophagectomy for tumours in the upper (n = 3), middle (n = 12) and lower (n = 22) thirds of the oesophagus. Four tumours arose in association with Barrett's oesophagus. Dysphagia for solids was the presenting symptom in 95% of cases. Orringer's technique was used and all cervical anastomoses were hand-sewn. The median duration of surgery was 2.9 (range 1.5-4.0) h and the 30-day hospital mortality rate was 16% (six patients). Respiratory complications were considerable (48%) and accounted for three deaths. Median postoperative stay was 21 (range 13-53 days) while median stay in the intensive care unit was 8.5 days. The majority (97%) of patients had stage III disease and 14 (38%) had lymph node involvement. The actuarial survival was 56% at 1 year and 31% at 2 years. Of the operative survivors, 90% resumed normal swallowing although 17 (55%) required outpatient dilatation. Transhiatal oesophagectomy provides safe and efficient palliation while mortality and 1-year survival rates compare with the transthoracic approach.

Clinical value of CYFRA 21.1, carcinoembryonic antigen, neurone-specific enolase, tissue polypeptide specific antigen and tissue polypeptide antigen in the diagnosis of lung cancer.

In this study we looked at what useful information cytokeratin fragment detected by antibodies BM 19-21 and KS 19-1 (CYFRA 21.1), carcinoembryonic antigen (CEA), neurone-specific enolase (NSE), tissue polypeptide specific antigen (TPS), and tissue polypeptide antigen (TPA) gave when measured prospectively. All patients who were suspected of having lung cancer and who underwent diagnostic bronchoscopy in this hospital between July 1994 and May 1995 were included in the study. Of 184 patients, 87 were subsequently found to have intrathoracic malignancy, 93 were found to have benign lung disease and four were lost to follow-up. CYFRA 21.1 was the most efficient marker in differentiating benign from malignant disease, with a sensitivity of 54% and a positive predictive value of 96%. Thirty seven patients who had a negative bronchoscopy subsequently turned out to have malignant disease. Either CYFRA 21.1 or CEA was elevated in 26 (70%) of such patients. Multivariate analysis showed that only CYFRA 21.1 and CEA contributed significantly to the discriminatory power of the data. We conclude that measurement of cytokeratin fragment detected by antibodies BM 19-21 and KS 19-1 and carcinoembryonic antigen at the time of bronchoscopy significantly increased the diagnostic yield in this population and was especially useful in those patients in whom tumour biopsy was not possible at bronchoscopy.