Detalhe da pesquisa
1.
The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system.
J Cell Sci
; 136(6)2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36825945
2.
Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis.
Brain
; 146(12): 4916-4934, 2023 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37849234
3.
The Parkinson's disease gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3.
J Cell Sci
; 132(20)2019 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31540955
4.
Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.
Hum Mol Genet
; 24(18): 5126-41, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26089202
5.
PINK1 signalling in cancer biology.
Biochim Biophys Acta
; 1846(2): 590-8, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25450579
6.
Dementia research in Ireland: What should we prioritise?
HRB Open Res
; 6: 12, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37954094
7.
Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.
Hum Mol Genet
; 24(25): 7450, 2015 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26534778
8.
Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease.
Biochem Soc Trans
; 40(4): 721-7, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22817723
9.
Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson's disease.
Commun Biol
; 4(1): 1140, 2021 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34588600
10.
Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons.
Neurosci Lett
; 720: 134777, 2020 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31978495
11.
Nigral overexpression of α-synuclein in a rat Parkinson's disease model indicates alterations in the enteric nervous system and the gut microbiome.
Neurogastroenterol Motil
; 32(1): e13726, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31576631
12.
Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells.
Br J Nutr
; 100(2): 287-96, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18186953
13.
Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain.
FEBS Lett
; 580(28-29): 6550-60, 2006 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17113083
14.
Gut microbes metabolize Parkinson's disease drug.
Science
; 364(6445): 1030-1031, 2019 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31196998
15.
PI3-kinase/Akt/mTOR signaling: impaired on/off switches in aging, cognitive decline and Alzheimer's disease.
Exp Gerontol
; 48(7): 647-53, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23470275
16.
The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-ß plaque and glial pathology in a mouse model of Alzheimer's disease.
Neuromolecular Med
; 15(1): 102-14, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23011726
17.
PINK1, cancer and neurodegeneration.
Oncoscience
; 3(1): 1-2, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26973853
18.
Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling.
Neurobiol Aging
; 31(2): 224-43, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18479783
19.
Akt signal transduction dysfunction in Parkinson's disease.
Neurosci Lett
; 467(1): 30-5, 2009 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19800394
20.
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology.
J Neurochem
; 93(1): 105-17, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15773910