RESUMO
Thyroid volume was measured by ultrasonography in 500 healthy adults living in an area with endemic goitre: in all subjects the mean value was 13.35 ml, in males (14.94 ml) the volume was significantly greater than in females (12.09 ml). The thyroid volume was significantly correlated with age, body weight and body surface. These data are compared with the results of other investigators. The ultrasonic procedure is the only exact method for thyroid volume calculation, the palpation of thyroid gland only is less accurate.
Assuntos
Bócio Endêmico/diagnóstico , Glândula Tireoide/patologia , Ultrassonografia , Adolescente , Adulto , Idoso , Áustria , Feminino , Bócio Endêmico/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Tamanho do Órgão , Valores de ReferênciaRESUMO
We report the case of a 30-year-old woman who presented with an EBV related hemophagocytic syndrome. After a few months she developed a T-cell rich B-cell non-Hodgkin's lymphoma with liver involvement. Serological data demonstrated a reactivation of the EBV infection. Tumor progression with liver involvement occurred during treatment with conventional chemotherapy. Tumor reduction and disappearance of all masses was seen after starting high-dose sequential chemotherapy, followed by an autologous peripheral blood progenitor transplantation LMP-1 could be amplified in the tumor material by PCR technology, but no LMP-1 expression could be found in the few malignant B-cells with Reed-Sternberg morphology. Sequence analysis of the carboxy terminal of the LMP-1 region revealed the naturally occurring 30 bp deletion variant of the LMP-1 with multiple point mutations within the NF kb region. Since LMP-1 was not expressed in the malignant tumor cells, no evidence could be found, that EBV participated in the tumorigenesis of this case.
Assuntos
Infecções por Herpesviridae/complicações , Herpesvirus Humano 4 , Histiocitose de Células não Langerhans/complicações , Linfoma de Células B/etiologia , Infecções Tumorais por Vírus/complicações , Adulto , Proteínas de Transporte/análise , Feminino , Humanos , Proteínas da Matriz Viral/análiseRESUMO
A 22 weeks pregnant women was affected by a life-threatening pneumonia and a paresis of the proximal muscles with cerebrospinal fluid pleocytosis. Her past medical history had been unremarkable except for recurrent episodes of paraumbilical herpes zoster. The clinical findings suggested a dissemination of varicella-zoster virus without skin lesions. Acyclovir was added to the therapy, and the clinical picture began to improve. Varicella-zoster virus DNA was detected in placental tissue by DNA-hybridisation analysis.