Detalhe da pesquisa
1.
A novel transient receptor potential C3/C6 selective activator induces the cellular uptake of antisense oligonucleotides.
Nucleic Acids Res
; 52(9): 4784-4798, 2024 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38621757
2.
Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N'- methylguanidine-bridged nucleic acids.
Nucleic Acids Res
; 51(15): 7749-7761, 2023 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37462081
3.
Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery.
Bioconjug Chem
; 35(2): 125-131, 2024 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38290165
4.
Lantern-type G-quadruplex fluorescent sensors for detecting divalent metal ions.
Anal Biochem
; 690: 115525, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38554995
5.
Synthesis, Duplex-Forming Ability, and Enzymatic Stability of Oligonucleotides Modified with Amide-Linked Dinucleotides Containing a 3',4'-Tetrahydropyran-Bridged Nucleic Acid.
J Org Chem
; 89(1): 269-280, 2024 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38064209
6.
Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides.
Nucleic Acids Res
; 50(13): 7224-7234, 2022 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35801870
7.
Synthesis of Coumarin-Conjugated Oligonucleotides via Knoevenagel Condensation to Prepare an Oligonucleotide Library.
Chem Pharm Bull (Tokyo)
; 72(2): 143-148, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38296555
8.
Novel strategy of liver cancer treatment with modified antisense oligonucleotides targeting human vasohibin-2.
Cancer Sci
; 114(9): 3740-3749, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37430466
9.
An antisense amido-bridged nucleic acid gapmer oligonucleotide targeting SRRM4 alters REST splicing and exhibits anti-tumor effects in small cell lung cancer and prostate cancer cells.
Cancer Cell Int
; 23(1): 8, 2023 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36650528
10.
Post-Synthetic Nucleobase Modification of Oligodeoxynucleotides by Sonogashira Coupling and Influence of Alkynyl Modifications on the Duplex-Forming Ability.
Chemistry
; 29(63): e202301928, 2023 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37635089
11.
Synthesis and Properties of Nucleobase-Sugar Dual Modified Nucleic Acids: 2'-OMe-RNA and scpBNA Bearing a 5-Hydroxycytosine Nucleobase.
J Org Chem
; 88(1): 154-162, 2023 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36520114
12.
Synthesis and properties of a novel modified nucleic acid, 2'-N-methanesulfonyl-2'-amino-locked nucleic acid.
Bioorg Med Chem Lett
; 88: 129289, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37068560
13.
Synthesis of multivalent fatty acid-conjugated antisense oligonucleotides: Cell internalization, physical properties, and in vitro and in vivo activities.
Bioorg Med Chem
; 81: 117192, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36780806
14.
2'-N-Alkylaminocarbonyl-2'-amino-LNA: Synthesis, duplex stability, nuclease resistance, and in vitro anti-microRNA activity.
Bioorg Med Chem
; 78: 117148, 2023 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36580743
15.
Synthesis and biophysical properties of tetravalent PEG-conjugated antisense oligonucleotide.
Bioorg Med Chem
; 78: 117149, 2023 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36587552
16.
Systematic Analysis of 2'-O-Alkyl Modified Analogs for Enzymatic Synthesis and Their Oligonucleotide Properties.
Molecules
; 28(23)2023 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38067640
17.
Physicochemical property evaluation of modified oligonucleotides by traveling-wave ion mobility mass spectrometry.
Rapid Commun Mass Spectrom
; 36(10): e9279, 2022 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35203101
18.
Parallel synthesis of oligonucleotides containing N-acyl amino-LNA and their therapeutic effects as anti-microRNAs.
Org Biomol Chem
; 20(47): 9351-9361, 2022 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36383101
19.
Synthesis and physical and biological properties of 1,3-diaza-2-oxophenoxazine-conjugated oligonucleotides.
Bioorg Med Chem
; 72: 116972, 2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36057217
20.
Synthesis, Duplex-Forming Ability, and Nuclease Resistance of Oligonucleotides Containing a Thymidine Derivative with a 1-Oxaspiro[4.5]decane Skeleton.
Chem Pharm Bull (Tokyo)
; 70(10): 699-706, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36184452