Detalhe da pesquisa
1.
Ligand deconstruction: Why some fragment binding positions are conserved and others are not.
Proc Natl Acad Sci U S A
; 112(20): E2585-94, 2015 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25918377
2.
Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias.
Blood
; 126(22): 2479-83, 2015 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26443624
3.
Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71.
J Labelled Comp Radiopharm
; 59(3): 129-32, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26806023
4.
Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1).
Bioorg Med Chem Lett
; 23(21): 5971-4, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24042005
5.
Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 2. Tadalafil analogs.
Bioorg Med Chem Lett
; 22(7): 2582-4, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22377518
6.
Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs.
Bioorg Med Chem Lett
; 22(7): 2579-81, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22370268
7.
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system.
Nat Commun
; 12(1): 4669, 2021 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34344873
8.
First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer.
Clin Cancer Res
; 26(19): 5178-5187, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32366671
9.
Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei.
Chem Biol Drug Des
; 85(5): 549-64, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25283372
10.
Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.
J Med Chem
; 58(9): 3922-43, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25901531
11.
A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species.
Cell Rep
; 13(10): 2159-73, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26628369
12.
Selective targeting of the stress chaperome as a therapeutic strategy.
Trends Pharmacol Sci
; 35(11): 592-603, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25262919
13.
Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions.
Expert Opin Investig Drugs
; 23(5): 611-28, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24669860
14.
Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer.
ACS Chem Biol
; 9(8): 1698-705, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24934503
15.
The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing.
Eur J Med Chem
; 62: 777-84, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22889561
16.
Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness.
J Med Chem
; 54(23): 8188-94, 2011 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22023548