Detalhe da pesquisa
1.
Sodium channel ß1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis.
J Biol Chem
; 295(30): 10380-10393, 2020 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32503841
2.
Drugging the undruggable: gabapentin, pregabalin and the calcium channel α2δ subunit.
Crit Rev Biochem Mol Biol
; 51(4): 246-56, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-27112431
3.
Anxiolytic-like activity of pregabalin in the Vogel conflict test in α2δ-1 (R217A) and α2δ-2 (R279A) mouse mutants.
J Pharmacol Exp Ther
; 338(2): 615-21, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21558437
4.
Sodium channel ß1 subunits participate in regulated intramembrane proteolysis-excitation coupling.
JCI Insight
; 6(3)2021 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33411695
5.
SCN1B-linked early infantile developmental and epileptic encephalopathy.
Ann Clin Transl Neurol
; 6(12): 2354-2367, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31709768
6.
Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes.
Stem Cell Reports
; 11(3): 626-634, 2018 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30146492
7.
Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice.
Brain Res
; 1075(1): 68-80, 2006 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-16460711
8.
Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants.
Epilepsy Res
; 108(5): 833-42, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24698052
9.
Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome.
PLoS One
; 8(10): e77843, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24155976
10.
Genetic approaches to a better understanding of bipolar disorder.
Pharmacol Ther
; 133(2): 133-41, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22004838
11.
Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: basic characterization and drug pharmacology.
Brain Res
; 1401: 1-9, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21664606
12.
The alpha2-delta protein: an auxiliary subunit of voltage-dependent calcium channels as a recognized drug target.
Curr Opin Investig Drugs
; 11(7): 761-70, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20571971
13.
Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.
Proc Natl Acad Sci U S A
; 103(46): 17537-42, 2006 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17088553