Detalhe da pesquisa
1.
Oral cedazuridine/decitabine for MDS and CMML: a phase 2 pharmacokinetic/pharmacodynamic randomized crossover study.
Blood
; 136(6): 674-683, 2020 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32285126
2.
A commentary on the use of pharmacoenhancers in the pharmaceutical industry and the implication for DMPK drug discovery strategies.
Xenobiotica
; 52(8): 786-796, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36537234
3.
Role of cedazuridine/decitabine in the management of myelodysplastic syndrome and chronic myelomonocytic leukemia.
Future Oncol
; 17(16): 2077-2087, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33709786
4.
Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer.
Invest New Drugs
; 38(4): 1085-1095, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31605293
5.
Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study.
Lancet Oncol
; 16(9): 1099-1110, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26296954
6.
SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome.
Int J Cancer
; 135(9): 2223-31, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24668305
7.
Oral decitabine-cedazuridine versus intravenous decitabine for myelodysplastic syndromes and chronic myelomonocytic leukaemia (ASCERTAIN): a registrational, randomised, crossover, pharmacokinetics, phase 3 study.
Lancet Haematol
; 11(1): e15-e26, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38135371
8.
A validated liquid chromatography-tandem mass spectroscopy method for the quantification of tolinapant in human plasma.
Anal Sci Adv
; 3(5-6): 198-204, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38716121
9.
Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.
Proc Natl Acad Sci U S A
; 105(25): 8754-9, 2008 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18559859
10.
In vitro metabolism, permeability, and efflux of bazedoxifene in humans.
Drug Metab Dispos
; 38(9): 1471-9, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20516255
11.
Characterization of HKI-272 covalent binding to human serum albumin.
Drug Metab Dispos
; 38(7): 1083-93, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20400660
12.
Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model.
Target Oncol
; 15(2): 231-240, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32222953
13.
A Phase I Study of ASTX660, an Antagonist of Inhibitors of Apoptosis Proteins, in Adults with Advanced Cancers or Lymphoma.
Clin Cancer Res
; 26(12): 2819-2826, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31900279
14.
A Randomized Phase II Trial of Epigenetic Priming with Guadecitabine and Carboplatin in Platinum-resistant, Recurrent Ovarian Cancer.
Clin Cancer Res
; 26(5): 1009-1016, 2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31831561
15.
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
J Pharmacol Exp Ther
; 331(2): 598-608, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19671883
16.
(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor.
Bioorg Med Chem Lett
; 19(3): 926-9, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19097890
17.
Development, validation, and clinical application of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of total intracellular ß-decitabine nucleotides and genomic DNA incorporated ß-decitabine and 5-methyl-2'-deoxycytidine.
J Pharm Biomed Anal
; 164: 16-26, 2019 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30366147
18.
Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite ßdecitabine in human plasma, whole blood and urine.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1109: 132-141, 2019 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30754019
19.
Pharmacodynamic and Clinical Results from a Phase I/II Study of the HSP90 Inhibitor Onalespib in Combination with Abiraterone Acetate in Prostate Cancer.
Clin Cancer Res
; 25(15): 4624-4633, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31113841
20.
An oral fixed-dose combination of decitabine and cedazuridine in myelodysplastic syndromes: a multicentre, open-label, dose-escalation, phase 1 study.
Lancet Haematol
; 6(4): e194-e203, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926081