Detalhe da pesquisa
1.
A Proof-of-Concept Study Evaluating the Phosphodiesterase 10A Inhibitor PF-02545920 in the Adjunctive Treatment of Suboptimally Controlled Symptoms of Schizophrenia.
J Clin Psychopharmacol
; 39(4): 318-328, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31205187
2.
Effect of Renal Impairment on the Pharmacokinetics of a Single Oral Dose of Danuglipron in Participants With Type 2 Diabetes.
J Clin Pharmacol
; 64(4): 449-460, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-37840155
3.
Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.
Bioorg Med Chem Lett
; 23(11): 3443-7, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23597790
4.
Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.
Bioorg Med Chem Lett
; 23(11): 3438-42, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23582272
5.
Evaluation of pharmacokinetic/pharmacodynamic relationships of PD-0162819, a biotin carboxylase inhibitor representing a new class of antibacterial compounds, using in vitro infection models.
Antimicrob Agents Chemother
; 56(1): 124-9, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21986824
6.
A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore.
Proc Natl Acad Sci U S A
; 106(6): 1737-42, 2009 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19164768
7.
The histamine skin prick test: An analysis of the method for use in clinical trials.
Ann Allergy Asthma Immunol
; 117(4): 433-435, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27519579
8.
Safety, Tolerability, and Pharmacokinetics of Multiple Repeated Oral Doses of the α2/3/5-Subtype Selective GABAA -Positive Allosteric Modulator PF-06372865 in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 10(7): 756-764, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33465277
9.
Addition of PNU-100480 to first-line drugs shortens the time needed to cure murine tuberculosis.
Am J Respir Crit Care Med
; 180(4): 371-6, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19520903
10.
Photosensitive epilepsy: Robust clinical efficacy of a selective GABA potentiator.
Neurology
; 92(15): e1786-e1795, 2019 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30877186
11.
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.
J Med Chem
; 61(3): 1001-1018, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29293004
12.
In vivo measurement of PDE10A enzyme occupancy by positron emission tomography (PET) following single oral dose administration of PF-02545920 in healthy male subjects.
Neuropharmacology
; 117: 171-181, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28122201
13.
Pentostatin in steroid-refractory acute graft-versus-host disease.
J Clin Oncol
; 23(12): 2661-8, 2005 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15837980
14.
First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430.
J Nucl Med
; 57(9): 1388-95, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27103022
15.
Suramin as a chemosensitizer: oral pharmacokinetics in rats.
Pharm Res
; 21(11): 2058-63, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15587928