Molecular finds of pressure ulcer: A bioinformatics approach in pressure ulcer.

BACKGROUND: Understanding the biological processes underlying Pressure Ulcer (PU) is an important strategy to identify new molecular targets. Bioinformatics has emerged as an important screening tool for a broad range of diseases. OBJECTIVE: This study aim of the current study is to investigate the protein-protein interaction in the PU context by bioinformatics. METHODS: We performed a search in gene databases, and bioinformatics algorithms were used to generate molecular targets for PU based in silico investigation. Interactions networks between protein-coding genes were built and compared to skin. RESULTS: TNFA, MMP9, and IL10 genes have higher disease-related connectivity than a connectivity general global. MAGOH, UBC, and PTCH1 as were leader genes related to skin. Ontological analysis demonstrated different mechanisms associated, such as response to oxidase stress. CONCLUSION: TNFA, MMP9, and IL10 are possible therapeutic targets for pressure ulcer. Additional investigation of cell post-transcriptional machinery should be investigated in PU.

Aspectos emocionales de los profesionales de enfermería en atenciónoncológica pediátrica: narrativa fenomenológica / Aspectos emocionais dos profissionais da enfermagem no cuidado em oncologia pediátrica: narrativa fenomenológica / Emotional aspects of nursing professionals in pediatric oncology care: phenomenological narrative

Objetivo: describir los aspectos emocionales de los profesionales de enfermeríainvolucrados en la atención oncológica pediátrica. Método: Estudio cualitativo exploratoriodescriptivo, realizado en 2014, con 14 profesionales de enfermería que trabajan con oncologíapediátrica en hospitales generales. Para la recolección de datos utilizamos la entrevistasemiestructurada. Los datos presentados en forma narrativa y sometidos a análisis de contenidotemático, tienen como perspectiva teórica de interpretación de datos, fenomenología. Resultados:se observó que la participación, la solidaridad entre ellos estaban presentes en la mayoría de lasdeclaraciones de los entrevistados. Sin embargo, hubo quienes utilizaron el distanciamiento devivir con niños, la racionalización de acciones para enfrentar la realidad oncológica infantil.Conclusión: Tratar con niños con cáncer provocó emociones relacionadas con el afecto, elsufrimiento, el escape y la compasión en los profesionales de enfermería. La oferta de apoyoemocional especializado a estos profesionales puede contribuir a aliviar la posible interrupciónresultante del trabajo con oncología pediátrica.(AU)

Objective: To describe the emotional aspects of nursing professionals involved in pediatriconcology care. Method: Qualitative, exploratory-descriptive study, conducted in 2014, with 14nursing professionals working with pediatric oncology in general hospitals. For data collection weused the semi-structured interview. The data presented in narrative form and submitted to thematiccontent analysis, having as a theoretical perspective of data interpretation, phenomenology.Results: It was noticed that the involvement, solidarity with each other were present in most of theinterviewees' statements. However, there were those who used the distancing of living withchildren, rationalization of actions to deal with childhood oncological reality. Conclusion: Dealingwith children with cancer elicited emotions related to affection, suffering, escape and compassionin nursing professionals. The offer of specialized emotional support to these professionals cancontribute to alleviate possible disruption resulting from work with pediatric oncology.(AU)

Objetivo: Descrever os aspectos emocionais dos profissionais da enfermagem envolvidosno cuidado em oncologia pediátrica. Método: Estudo qualitativo, exploratório-descritivo, realizadoem 2014, com 14 profissionais da enfermagem que trabalham com oncologia pediátrica emhospitais gerais. Para a coleta de dados utilizou-se a entrevista semiestruturada. Os dadosapresentados sob a forma de narrativa e submetidos à análise temática de conteúdo, tendo comoperspectiva teórica de interpretação dos dados, a fenomenologia. Resultados: Percebeu-se que oenvolvimento, o solidarizar-se com o outro estiveram presentes em grande parte das falas dosentrevistados. No entanto, houve quem se valesse do distanciamento do convívio com as crianças,racionalização das ações, para lidar com a realidade oncológica infantil. Conclusão: O lidar com rianças com câncer suscitou nos profissionais da enfermagem emoções relacionadas ao afeto,sofrimento, fuga e compaixão. A oferta de amparo emocional especializado a esses profissionaispode contribuir para amenizar possíveis abalos decorrentes do trabalho com oncologia pediátrica.(AU)

El parto realizado por matronas: una revisión integradora / The work performed by the childbirth midwives: an integrative review

Este artículo tiene como objetivo analizar las tendencias de las publicaciones sobre el trabajo realizado en casa por parteras. Se realizó una revisión integradora en las bases de datos LILACS y SciELO, en febrero de 2012. Se utilizaron las palabras clave: parteras tradicionales; parto domiciliario; parto normal. Tuveron los siguientes criterios de inclusión: los artículos completos en portugués y español, presentar el contenido que cumpla con los objetivos del estudio y que fueron publicados entre enero de 2002 y enero de 2012. La muestra se compone de 13 artículos sometidos a análisis de contenido temático y clasificación del nivel de evidencia. Se evidenciaron las siguientes categorías: "El reconocimiento social de las parteras", "La elección del parto en casa para las mujeres", "La atención de las parteras con la madre y el niño". Para las mujeres embarazadas, el parto en casa permite varias ventajas como la comodidad, la autonomía, intimidad, y sobre todo la libertad de movimiento. Las parteras realizaron el cuidado en prenatal y posparto con el fin de salvaguardar y prevenir problemas de salud tanto para la madre y el niño. Se observó que el reconocimiento de la comunidad fue, para las parteras, la mayor recompensa por su trabajo. Hay una gran necesidad de más estudios sobre este tema, ya que esta práctica seguirá durante muchos años, porque las parteras desempeñan y siempre desempeñarán un papel importante en las vidas de las mujeres que desean este tipo de entrega(AU)

The study was aimed to analyze the trend of publications about the childbirth performed at home by midwives. It is an integrative review performed in the databases LILACS and SciELO in February of 2012. The following key-words were used: midwives practical, home childbirth and natural childbirth. The inclusion criteria were: full papers in Portuguese and Spanish, in which the content meets the goals of the study and were published from January 2002 to January 2012. The sample was composed by 13 articles and submitted to thematic content analysis with evidence level of classification. There were emerged the following categories: "the choice of home childbirth", "the care of midwives with the mother and baby" and "social recognition of midwives." For pregnant women, birth at home, allowed several advantages such as comfort, autonomy, privacy, and especially freedom of movement. It was observed that midwives performed antenatal and postpartum in order to safeguard and prevent health problems for both the mother and the baby. It was evident that the community's recognition was for the midwives, the greatest reward for your work. It is a great need for more studies on this topic, since this practice perpetuated along the years, because the midwives play and always play a big role in the lives of women who want this type of delivery(AU)