Detalhe da pesquisa
1.
Madurella mycetomatis, the main causative agent of eumycetoma, is highly susceptible to olorofim.
J Antimicrob Chemother
; 75(4): 936-941, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31904836
2.
F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase.
Proc Natl Acad Sci U S A
; 113(45): 12809-12814, 2016 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27791100
3.
Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus.
Antimicrob Agents Chemother
; 62(8)2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29891595
4.
Anti-Aspergillus activities of olorofim at sub-MIC levels during early-stage growth.
Microbiol Spectr
; 12(3): e0330423, 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38315027
5.
Aspergillus fumigatus strains that evolve resistance to the agrochemical fungicide ipflufenoquin in vitro are also resistant to olorofim.
Nat Microbiol
; 9(1): 29-34, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38151646
6.
Characterisation of putative class 1A DHODH-like proteins from Mucorales and dematiaceous mould species.
PLoS One
; 18(8): e0289441, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37531380
7.
Resistance profiling of Aspergillus fumigatus to olorofim indicates absence of intrinsic resistance and unveils the molecular mechanisms of acquired olorofim resistance.
Emerg Microbes Infect
; 11(1): 703-714, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35109772
8.
Functional analysis of a mitochondrial phosphopantetheinyl transferase (PPTase) gene pptB in Aspergillus fumigatus.
Fungal Genet Biol
; 48(4): 456-64, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21195204
9.
The transposon impala is activated by low temperatures: use of a controlled transposition system to identify genes critical for viability of Aspergillus fumigatus.
Eukaryot Cell
; 9(3): 438-48, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20097738
10.
The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus.
J Fungi (Basel)
; 6(2)2020 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32290206
11.
Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance.
mBio
; 10(6)2019 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31796539
12.
A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity.
mBio
; 8(4)2017 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28720735
13.
Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate.
Toxicol Sci
; 86(2): 453-69, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15901911
14.
Characterisation of the Candida albicans Phosphopantetheinyl Transferase Ppt2 as a Potential Antifungal Drug Target.
PLoS One
; 10(11): e0143770, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26606674
15.
The Aspergillus fumigatus dihydroxyacid dehydratase Ilv3A/IlvC is required for full virulence.
PLoS One
; 7(9): e43559, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23028460
16.
Receptor-mediated hepatocarcinogenesis: role of hepatocyte proliferation and apoptosis.
Pharmacol Toxicol
; 91(1): 1-7, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12193254
17.
Tail-anchored and signal-anchored proteins utilize overlapping pathways during membrane insertion.
J Biol Chem
; 278(8): 5669-78, 2003 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12464599
18.
The primary substrate binding site in the b' domain of ERp57 is adapted for endoplasmic reticulum lectin association.
J Biol Chem
; 279(18): 18861-9, 2004 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-14871899