Using antenatal care as a platform for malaria surveillance data collection: study protocol.

BACKGROUND: While many malaria-endemic countries have health management information systems that can measure and report malaria trends in a timely manner, these routine systems have limitations. Periodic community cross-sectional household surveys are used to estimate malaria prevalence and intervention coverage but lack geographic granularity and are resource intensive. Incorporating malaria testing for all women at their first antenatal care (ANC) visit (i.e., ANC1) could provide a more timely and granular source of data for monitoring trends in malaria burden and intervention coverage. This article describes a protocol designed to assess if ANC-based surveillance could be a pragmatic tool to monitor malaria. METHODS: This is an observational, cross-sectional study conducted in Benin, Burkina Faso, Mozambique, Nigeria, Tanzania, and Zambia. Pregnant women attending ANC1 in selected health facilities will be tested for malaria infection by rapid diagnostic test and administered a brief questionnaire to capture key indicators of malaria control intervention coverage and care-seeking behaviour. In each location, contemporaneous cross-sectional household surveys will be leveraged to assess correlations between estimates obtained using each method, and the use of ANC data as a tool to track trends in malaria burden and intervention coverage will be validated. RESULTS: This study will assess malaria prevalence at ANC1 aggregated at health facility and district levels, and by gravidity relative to current pregnancy (i.e., gravida 1, gravida 2, and gravida 3 +). ANC1 malaria prevalence will be presented as monthly trends. Additionally, correlation between ANC1 and household survey-derived estimates of malaria prevalence, bed net ownership and use, and care-seeking will be assessed. CONCLUSION: ANC1-based surveillance has the potential to provide a cost-effective, localized measure of malaria prevalence that is representative of the general population and useful for tracking monthly changes in parasite prevalence, as well as providing population-representative estimates of intervention coverage and care-seeking behavior. This study will evaluate the representativeness of these measures and collect information on operational feasibility, usefulness for programmatic decision-making, and potential for scale-up of malaria ANC1 surveillance.

Preferences for oral- vs blood-based human immunodeficiency virus self-testing: A scoping review of the literature.

BACKGROUND: The evidence on preferences for oral- vs blood-based human immunodeficiency virus self-testing (HIVST) has been heterogenous and inconclusive. In addition, most evaluations have relied on hypothetical or stated use cases using discreet choice experiments rather than actual preferences among experienced users, which are more objective and critical for the understanding of product uptake. Direct head-to-head comparison of consumer preferences for oral- versus blood-based HIVST is lacking. AIM: To examine the existing literature on preferences for oral- vs blood-based HIVST, determine the factors that impact these preferences, and assess the potential implications for HIVST programs. METHODS: Databases such as PubMed, Medline, Google Scholar, and Web of Science were searched for articles published between January 2011 to October 2022. Articles must address preferences for oral- vs blood-based HIVST. The study used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist to ensure the quality of the study. RESULTS: The initial search revealed 2424 records, of which 8 studies were finally included in the scoping review. Pooled preference for blood-based HIVST was 48.8% (9%-78.6%), whereas pooled preference for oral HIVST was 59.8% (34.2%-91%) across all studies. However, for male-specific studies, the preference for blood-based HIVST (58%-65.6%) was higher than that for oral (34.2%-41%). The four studies that reported a higher preference for blood-based HIVST were in men. Participants considered blood-based HIVST to be more accurate and rapid, while those with a higher preference for oral HIVST did so because these were considered non-invasive and easy to use. CONCLUSION: Consistently in the literature, men preferred blood-based HIVST over oral HIVST due to higher risk perception and desire for a test that provides higher accuracy coupled with rapidity, autonomy, privacy, and confidentiality, whereas those with a higher preference for oral HIVST did so because these were considered non-invasive and easy to use. Misinformation and distrust need to be addressed through promotional messaging to maximize the diversity of this new biomedical technology.

Acceptability and strategies for enhancing uptake of human immunodeficiency virus self-testing in Nigeria.

BACKGROUND: In 2019, the Nigerian Ministry of Health published the first operational guidelines for human immunodeficiency virus self-testing (HIVST) to improve access to human immunodeficiency virus (HIV) testing services among undertested populations in the country. Also, as part of the campaign to increase HIV testing services in Nigeria, the Nigerian Ministry of Health developed standard operating procedures for using HIVST kits. AIM: To systematically review the acceptability and strategies for enhancing the uptake of HIVST in Nigeria. METHODS: The systematic review was conducted and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Different databases were searched to get the necessary materials needed for this review. Standardized forms developed by the authors were used for data extraction to minimize the risk of bias and ensure that the articles used for the study were properly screened. Identified articles were first screened using the titles and their abstracts. The full papers were screened, and the similarities of the documents were determined. Qualitative, quantitative, and mixed-method studies were evaluated using the Critical Appraisal Skills Programme and Critical Appraisal Framework criteria. RESULTS: All the publications reviewed were published between 2015 and 2022, with 33.3% published in 2021. Most (77.8%) of the studies were cross-sectional, 43.3% were conducted in Lagos State, and 26.3% were conducted among young people. The study revealed a high level of acceptability of HIVST. Certain factors, such as gender, sexual activity, and previous testing experience, influence the acceptability of HIV self-testing, with some individuals more likely to opt-out. The cost of the kit was reported as the strongest factor for choosing HIVST services, and this ranged from 200 to 4000 Naira (approximately United States Dollar 0.55-11.07), with the majority willing to pay 500 Naira (approximately United States Dollar 1.38). Privately-owned, registered pharmacies, youth-friendly centres, supermarkets, and online stores were the most cited access locations for HIVST. The least influential attribute was the type of specimen needed for HIVST. Strategies addressing cost and preferred access points and diverse needs for social media promotion, local translation of product use instructions, and HIVST distribution led by key opinion leaders for key populations were found to significantly enhance HIVST uptake and linkage to care. CONCLUSION: HIVST acceptability is generally high from an intention-to-use perspective. Targeted strategies are required to improve the acceptability of HIV self-testing, especially among males, sexually active individuals, and first-time testers. Identified and proposed uptake-enhancing strategies need to be investigated in controlled settings and among different populations and distribution models in Nigeria.

A comparative assessment of the level of stockouts of modern family planning services in private and public health facilities in Nigeria

Background: The use of family planning (FP) methods and stockouts of contraceptives are major challenges to the FP program in Sub-Saharan Africa. This study assessed the level of stockouts of contraceptives in Nigerian health facilities. This survey was carried out in 767 health facilities offering FP services across all six geopolitical zones of Nigeria. Materials and Methods: This was a cross-sectional study involving a quantitative technique. Data were collected from 116 private and 651 public health facilities in Nigeria. A structured questionnaire was used to collect data from the facilities, and a physical inventory was taken. Data were analyzed using IBM-SPSS, version 25.0. Results: The stockout rate in the last 3 months was 63.8% in private and 47.5% in public health facilities (P = 0.001), whereas stockouts on the visit day were 63.8% in private and 51.0% in public facilities (P = 0.011). On the day of the visit, the stockout rate in private health facilities ranged from 9.3% to 26.5%, whereas it ranged from 5.3% to 24.2% in public health facilities. The main causes of stockouts of some contraceptives are low/no demand and a lack of supply. Conclusions: This study found a high level of stockouts of FP services in private and public health facilities, but higher in private facilities. Both the poor supply and low demand for FP services in Nigeria require the attention of policymakers and health officials.

Estimation of maternal mortality ratio with sisterhood method in six local government areas of Oyo State, Nigeria

Background: The reduction of maternal mortality rate has been the top priority of global health, yet its persistently high rate in Africa is a severe issue that requires the attention of both the individual and policymakers. Objective: To determine the maternal mortality rate by applying the sisterhood method in six local government areas in Oyo State. Materials and Methods: The indirect sisterhood method was used to collect data concerning maternal mortality. For study purposes, the data were collected from women in the reproductive age group between 15 and 49 years using a structured questionnaire. Statistical Package for the Social Sciences version 25.0 software was used for analyzing the collected data. Results: It has been observed that the average maternal mortality rate in the six local government areas was 489/100,000 live births ranging from 346 to 756/100,000 live births. The highest maternal mortality rate was found in Iseyin local government area (756/100,000 live births), followed by 586/100,000 from Saki, 444 from Ibadan North, 430 from Ogbomosho, 374 from Atiba, and the least value of 346/100,000 live births in Ibadan North local government area. Conclusion: The maternal mortality rate has been found lower than the previous studies but still unacceptably high, especially among adolescents aged 15–39 years. Therefore, it is advocated that policymakers employ appropriate interventions such as the release of more funds for standard family planning and childbirth spacing programs to minimize maternal mortality in the state.

Impact of Comprehensive HIV/AIDS Prevention Program on Reduction of Risky Sexual Behaviors in an African Rural Community

Aims: This study compares the sexual behaviour of the residents of Bonny kingdom, Rivers Statein pre-intervention and post-intervention periods of a comprehensive HIV/AIDS prevention program carried out by the African Health Project in collaboration with independent research consultants and members of the Ibanise HIV/AIDS initiative in the community for three years from 2009-2012.Methodology:This is a quantitative survey that used a structured questionnaire among a representative sample of the general population aged 15 –49 years. Post-intervention survey was conducted three years after the pre-intervention survey. The data obtained include the demographics; age, sex, education, occupation, marital status and sexual related information. Data were analyzed using SPSS version 25.0.Results:This study comprised 1021 (53.3%) males and 895 females (46.7%) in the pre-intervention survey and 659 (54.2%) malesand 556 (45.7%) in the post-intervention survey, mostly aged 15-34 years and had secondary education. More females have ever had sex in both surveys but there was a significant reduction in the percentage of males who have ever had sex from 70.8% to 42.0%in pre-intervention and post-intervention surveys respectively. The rate of sexual activities was very high before intervention among unmarried males (51.6%), age 15-24 years (69.6%), secondary education (50.7%) and graduates (65.9%). However, there was adrastic reduction in these values after the interventions. During pre-intervention survey, 9.4% of females and 13% of males had ever accepted or given gifts exchange for sex while the post-intervention survey showed a decrease into 8.0% among females and 5.5% among males. This proportion was 13.0% among adolescents 15-24 years in the pre-intervention survey and 4.7% in the post-intervention survey. Also, there was 65.0% decrease in the proportion of singles who had ever received gifts in exchange for sexual intercourse after the intervention. A high proportion of the males had multiple sexual partners during the pre-intervention survey (34.6%) but the value reduced to 3.2% after the intervention. Similarly, the percentage of the adolescent who had multiple sexual partners reduce from 22.2% to 2.5% due to the intervention. The pre-intervention survey showed that about 56.0% of males and 81.0% of females had sex with non-marital partners while the post-intervention survey showed that about 71.0% of males and 76.0% of females did same.Conclusion:The study has shown a significant positive impact of health interventions in improving the sexual behaviour of Bonny residents. However, more and regular interventions are needed in this environment to further prevent the spread of HIV and STIs due to the vulnerability of the residents, especially the adolescents to sexually transmitted infection.There is also need for more study to evaluate the impact of sexual and reproductive health programs for adolescence and adultthat already exist in Nigeria in comparison with the HIV intervention outcome.

Evaluation of nine HIV rapid test kits to develop a national HIV testing algorithm in Nigeria.

Background: Non-cold chain-dependent HIV rapid testing has been adopted in many resource-constrained nations as a strategy for reaching out to populations. HIV rapid test kits (RTKs) have the advantage of ease of use, low operational cost and short turnaround times. Before 2005, different RTKs had been used in Nigeria without formal evaluation. Between 2005 and 2007, a study was conducted to formally evaluate a number of RTKs and construct HIV testing algorithms. Objectives: The objectives of this study were to assess and select HIV RTKs and develop national testing algorithms. Method: Nine RTKs were evaluated using 528 well-characterised plasma samples. These comprised 198 HIV-positive specimens (37.5%) and 330 HIV-negative specimens (62.5%), collected nationally. Sensitivity and specificity were calculated with 95% confidence intervals for all nine RTKs singly and for serial and parallel combinations of six RTKs; and relative costs were estimated. Results: Six of the nine RTKs met the selection criteria, including minimum sensitivity and specificity (both ≥ 99.0%) requirements. There were no significant differences in sensitivities or specificities of RTKs in the serial and parallel algorithms, but the cost of RTKs in parallel algorithms was twice that in serial algorithms. Consequently, three serial algorithms, comprising four test kits (BundiTM, DetermineTM, Stat-Pak® and Uni-GoldTM) with 100.0% sensitivity and 99.1% - 100.0% specificity, were recommended and adopted as national interim testing algorithms in 2007. Conclusion: This evaluation provides the first evidence for reliable combinations of RTKs for HIV testing in Nigeria. However, these RTKs need further evaluation in the field (Phase II) to re-validate their performance.