Detalhe da pesquisa
1.
N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model.
Bioorg Med Chem
; 26(18): 5169-5180, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30253886
2.
Agonist-induced internalization of CC chemokine receptor 5 as a mechanism to inhibit HIV replication.
J Pharmacol Exp Ther
; 337(3): 655-62, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21389095
3.
Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core.
J Med Chem
; 49(12): 3743-7, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759116
4.
A simple model to predict blood-brain barrier permeation from 3D molecular fields.
Biochim Biophys Acta
; 1587(2-3): 118-25, 2002 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12084453
5.
Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CB(1) cannabinoid receptor ligands and potential antagonists: synthesis, lipophilicity, affinity, and molecular modeling.
J Med Chem
; 45(9): 1748-56, 2002 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-11960486
6.
(E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine, a caffeine derivative acting both as antagonist of adenosine A2A receptors and as inhibitor of MAO-B.
Acta Crystallogr C
; 61(Pt 9): o531-2, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16143772
7.
Three 5H-indeno[1,2-c]pyridazin-5-one derivatives, potent type-B monoamine oxidase inhibitors.
Acta Crystallogr C
; 60(Pt 9): o623-6, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15345837
8.
Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling.
J Biol Chem
; 277(19): 17209-16, 2002 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-11861643
9.
Rational approaches towards reversible inhibition of type B monoamine oxidase. Design and evaluation of a novel 5H-Indeno[1,2-c]pyridazin-5-one derivative.
Bioorg Med Chem Lett
; 13(1): 69-73, 2003 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12467619