Detalhe da pesquisa
1.
A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
Brain
; 147(5): 1784-1798, 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38387080
2.
Alternative processing of human HTT mRNA with implications for Huntington's disease therapeutics.
Brain
; 145(12): 4409-4424, 2022 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35793238
3.
Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.
J Neurosci Res
; 97(12): 1590-1605, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31282030
4.
Dysfunction of the CNS-heart axis in mouse models of Huntington's disease.
PLoS Genet
; 10(8): e1004550, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25101683
5.
HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
PLoS Biol
; 11(11): e1001717, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24302884
6.
Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches.
Brain Commun
; 5(1): fcad010, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36756307
7.
Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms.
Brain Commun
; 3(1): fcaa231, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33604571
8.
Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington'S Disease Model.
Brain Commun
; 2(2): fcaa066, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32954323
9.
Meso scale discovery-based assays for the detection of aggregated huntingtin.
PLoS One
; 14(3): e0213521, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30913220
10.
Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington's disease mice.
Sci Rep
; 7(1): 14275, 2017 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29079832
11.
Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease.
PLoS One
; 9(6): e99520, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24955833
12.
HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo.
PLoS One
; 8(11): e80849, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24278330