Detalhe da pesquisa
1.
Design and Biochemical Characterization of Peptidic Inhibitors of the Myb/p300 Interaction.
Biochemistry
; 62(7): 1321-1329, 2023 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36883372
2.
Redox-Active Heteroatom-Functionalized Polyacetylenes.
Angew Chem Int Ed Engl
; 61(4): e202114586, 2022 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34826183
3.
Small-molecule factor D inhibitors targeting the alternative complement pathway.
Nat Chem Biol
; 12(12): 1105-1110, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27775713
4.
Gift from Nature: Cyclomarinâ A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action.
Chembiochem
; 16(17): 2433-6, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26472355
5.
trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: prime site exploration using an amino linker.
Bioorg Med Chem Lett
; 25(8): 1782-1786, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25782742
6.
trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker.
Bioorg Med Chem Lett
; 25(8): 1787-1791, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25754490
7.
Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV.
Bioorg Med Chem Lett
; 24(3): 731-6, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24439847
8.
Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes.
Bioorg Med Chem Lett
; 22(3): 1464-8, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22177783
9.
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Cancer Discov
; 12(6): 1500-1517, 2022 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35404998
10.
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors.
J Med Chem
; 65(24): 16173-16203, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36399068
11.
Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4.
J Med Chem
; 63(21): 12542-12573, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32930584
12.
Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.
ACS Med Chem Lett
; 9(5): 490-495, 2018 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29795765
13.
Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor.
J Mol Biol
; 355(2): 249-61, 2006 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-16305800
14.
Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.
J Med Chem
; 60(5): 1946-1958, 2017 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28157311
15.
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
J Med Chem
; 60(13): 5717-5735, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28621538
16.
Crystal structure of an activation intermediate of cathepsin E.
J Mol Biol
; 342(3): 889-99, 2004 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15342244
17.
Exploring T cell reactivity to gliadin in young children with newly diagnosed celiac disease.
Autoimmune Dis
; 2014: 927190, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24724018
18.
Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.
ACS Med Chem Lett
; 5(7): 787-92, 2014 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25050166
19.
The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.
J Med Chem
; 56(6): 2207-17, 2013 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23425156
20.
A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
J Med Chem
; 56(6): 2196-206, 2013 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23360239