Detalhe da pesquisa
1.
Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity.
J Pharmacol Exp Ther
; 377(1): 11-19, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33509901
2.
Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.
J Med Chem
; 66(21): 14912-14927, 2023 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37861679
3.
Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.
J Med Chem
; 65(8): 6001-6016, 2022 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35239336
4.
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
J Med Chem
; 65(24): 16801-16817, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475697
5.
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.
J Med Chem
; 65(1): 838-856, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34967623
6.
Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors.
ACS Med Chem Lett
; 12(3): 389-396, 2021 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33738066
7.
Purine derivatives as potent gamma-secretase modulators.
Bioorg Med Chem Lett
; 20(7): 2279-82, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207146
8.
Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors.
ACS Med Chem Lett
; 11(12): 2461-2469, 2020 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33335668
9.
Discovery and mechanistic study of Al(III)-catalyzed transamidation of tertiary amides.
J Am Chem Soc
; 130(2): 647-54, 2008 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-18092780
10.
Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1).
Bioorg Med Chem Lett
; 18(6): 1859-63, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18304810
11.
Mechanism of Al(III)-catalyzed transamidation of unactivated secondary carboxamides.
J Am Chem Soc
; 128(15): 5177-83, 2006 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-16608354
12.
Effects of side chain configuration and backbone spacing on the gene delivery properties of lysine-derived cationic polymers.
Bioconjug Chem
; 16(3): 694-9, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15898739