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1.
Environ Monit Assess ; 192(2): 132, 2020 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-31970535

RESUMO

Direct measurements, models, and risk maps play significant roles in assessment and monitoring of wind erosion cases. Although active and passive traps allow researchers to measure point sediment transports directly, it is also possible to make geostatistical analysis of wind erosion with grid and random sampling at multiple points. Geostatistical models can be used in multi-sample eolian researches to improve model success and update model parameters. The present study was conducted for case-based geostatistical analysis of sediment transport rates (STRs) over two adjacent dunes (plot A and B) with different vegetation cover rates between 22 May and 15 June 2011. The plot A has a vegetative cover ratio of 30%, while the plot B has a vegetation cover ratio of 2% and sand content of the plots is 88%. Actual mass transports were measured with BEST sediment traps. A total of 19 BEST sediment trap assemblies were placed randomly over the plot A and 21 were placed over the plot B. A climate station was installed over the research site to record climate data throughout the experimental period. There were two wind erosion cases during the research period. U test indicated that differences in sediment transport rates of the plots for each case were significant (p < 0.00). Spatial analyses of STRs (kg m-1 h-1) also exhibited case-based differences. While nugget effect was observed in case 1 of the plot B, the other case in both plots were modeled with spherical model. Maximum likelihood distances in plot A and B were respectively identified as 61 m and 1 m in the first case and as 13 m and 30 m in the second case. Total mass transport was measured as 112 kg m-1 in plot A and as 2162 kg m-1 in plot B. Consequently, it was found that 30% vegetation cover reduced the total mass transport dramatically.


Assuntos
Solo , Vento , Clima , Monitoramento Ambiental
2.
J Intern Med ; 285(1): 19-39, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30079527

RESUMO

Recent advancements in bioanalytical techniques have led to the development of novel and robust diagnostic approaches that hold promise for providing optimal patient treatment, guiding prevention programs and widening the scope of personalized medicine. However, these advanced diagnostic techniques are still complex, expensive and limited to centralized healthcare facilities or research laboratories. This significantly hinders the use of evidence-based diagnostics for resource-limited settings and the primary care, thus creating a gap between healthcare providers and patients, leaving these populations without access to precision and quality medicine. Smartphone-based imaging and sensing platforms are emerging as promising alternatives for bridging this gap and decentralizing diagnostic tests offering practical features such as portability, cost-effectiveness and connectivity. Moreover, towards simplifying and automating bioanalytical techniques, biosensors and lab-on-a-chip technologies have become essential to interface and integrate these assays, bringing together the high precision and sensitivity of diagnostic techniques with the connectivity and computational power of smartphones. Here, we provide an overview of the emerging field of clinical smartphone diagnostics and its contributing technologies, as well as their wide range of areas of application, which span from haematology to digital pathology and rapid infectious disease diagnostics.


Assuntos
Prática Clínica Baseada em Evidências , Smartphone , Técnicas Biossensoriais , Técnicas Citológicas , Humanos , Dispositivos Lab-On-A-Chip , Microfluídica , Aplicativos Móveis , Patologia Molecular , Sistemas Automatizados de Assistência Junto ao Leito , Impressão Tridimensional
3.
BMC Anesthesiol ; 18(1): 23, 2018 02 16.
Artigo em Inglês | MEDLINE | ID: mdl-29452603

RESUMO

BACKGROUND: Nesfatin-1 is involved in cardiovascular regulation, stress-related responses. The objective of this study is to investigate the impact of volatile anesthetics on Nesfatin-1 levels. METHOD: Fourty-two patients aged 30-65 years with the American Society Anesthesiology (ASA) Class I-II who were scheduled for laparoscopic cholecystectomy were included in the study Patients were randomized into two group; desflurane administered group (Group I, n = 21) and sevoflurane administered group (Group II, n = 21). For anesthesia maintenance, the patients received 6% desflurane or 2% sevoflurane in 40% O2 and 60% air. The patient's heart rate (HR), mean, systolic and diastolic arterial pressures (MAP, SAP, DAP), peripheral O2 saturation (SpO2) were monitored and recorded before induction, after induction, after intubation, and during extubation. Blood samples were collected before induction (T1), and after extubation when aldrete score was 10 (T2). RESULTS: Demographic data were similar between the groups. The preoperative levels of nesfatin were similar in the two groups (p = 0.715). In desflurane group, post-operative nesfatin levels were similar compared to preoperative levels (p = 0.073). In sevoflurane group, post-operative nesfatin levels were similar (p = 0.131). The nesfatin levels (postoperative vs preoperative) were similar between the groups (p = 0.900). CONCLUSION: In conclusion, this study results suggest that nesfatin-1 levels are not affected by the use of sevoflurane or desflurane in patients undergoing laparoscopic cholecystectomy. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry, ACTRN12617001023347 , retrospectively registered on 17 July 2017.


Assuntos
Anestésicos Inalatórios/farmacologia , Proteínas de Ligação ao Cálcio/sangue , Proteínas de Ligação ao Cálcio/efeitos dos fármacos , Colecistectomia Laparoscópica , Proteínas de Ligação a DNA/sangue , Proteínas de Ligação a DNA/efeitos dos fármacos , Desflurano/farmacologia , Proteínas do Tecido Nervoso/sangue , Proteínas do Tecido Nervoso/efeitos dos fármacos , Sevoflurano/farmacologia , Adulto , Idoso , Proteínas de Ligação ao Cálcio/genética , Proteínas de Ligação a DNA/genética , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Proteínas do Tecido Nervoso/genética , Nucleobindinas
4.
J Fr Ophtalmol ; 47(3): 104073, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38320466

RESUMO

PURPOSE: To evaluate the results of using a pigtail probe to open the inferior punctum followed by bicanalicular silicone tube intubation in patients with severe acquired punctal stenosis. METHODS: Forty-one eyes of 25 patients with severe inferior punctal stenosis admitted to our tertiary care center were included in the study. The degree of epiphora was determined using the Munk score and the fluorescein disappearance test. The inferior punctum was located and opened by entering the superior punctum with a pigtail probe. Then, bicanalicular silicone tube intubation was performed. The silicone tube was removed after six months. A Munk score of 0 or 1 and a fluorescein disappearance test score of 1 and 2 were considered a complete success. RESULTS: Ten (40%) patients were male, and 15 (60%) were female. The mean age was 60.4±15.5years. One year after the surgery, epiphora was absent in 18 eyes (43.9%) (Munk score grade 0) and rarely seen in 9 eyes (22%) (Munk score grade 1). At the one-year follow-up, the fluorescein disappearance test score was stage 1 (<3min) in 21 eyes (51.2%) and stage 2 (3-5min) in 13 eyes (31.7%). There was a statistically significant difference between the preoperative and one-year postoperative test results (P<0.001). CONCLUSION: In cases with severe punctal stenosis, a pigtail probe is an effective method for locating and opening the punctum, and punctal opening and prevention of restenosis were achieved by a bicanalicular stent.


Assuntos
Doenças Palpebrais , Aparelho Lacrimal , Obstrução dos Ductos Lacrimais , Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Silicones , Obstrução dos Ductos Lacrimais/diagnóstico , Obstrução dos Ductos Lacrimais/terapia , Constrição Patológica , Intubação/métodos , Aparelho Lacrimal/cirurgia , Fluoresceína
5.
J Fr Ophtalmol ; 47(4): 104135, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38447291

RESUMO

PURPOSE: To evaluate the effect of upper eyelid blepharoplasty surgery on corneal topography, visual field, ocular surface, meibography, corneal biomechanics and dry eye parameters. METHODS: This prospective study included a total 80 eyes of 40 patients. Following a detailed ophthalmological examination, standardized patient satisfaction questions were posed to patients before and after upper eyelid blepharoplasty surgery. Visual field test, non-invasive break up time (NIBUT), meibography, and corneal topography parameters were analyzed and evaluated. RESULTS: The mean (+) visible areas in the visual field were found to be 46.20±24.96 preoperatively, 56.73±21.98 at the 1st postoperative month and 65.96±18.5 at the 3rd month, which were statistically significant. NIBUT values preoperatively, at 1 month and at 3 months were 11.26±4.48, 11.16±4.5 and 10.14±4.0, respectively, which were statistically significant. Meibomian gland loss rates on meibography preoperatively and postoperatively at 1 and 3 months were found to be 30.24±8.3, 29.36±8.2 and 28.22±7.7 respectively and were statistically significant. With the scoring system after blepharoplasty, patients reported improvement in their symptoms. CONCLUSION: Upper eyelid blepharoplasty surgery is predicted to increase the quality of vision. It was observed that there was a functional and cosmetic improvement in the complaints of the patients after blepharoplasty. However, blepharoplasty may cause changes in eyelid dynamics and cause dry eye syndrome.


Assuntos
Blefaroplastia , Síndromes do Olho Seco , Humanos , Blefaroplastia/efeitos adversos , Campos Visuais , Estudos Prospectivos , Glândulas Tarsais , Síndromes do Olho Seco/diagnóstico , Síndromes do Olho Seco/epidemiologia , Síndromes do Olho Seco/etiologia
6.
Compr Psychiatry ; 54(6): 649-57, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23462415

RESUMO

OBJECTIVE: Our aim in this study was to compare the assessments of neuropsychological tests and the p50 neurophysiological test of patients with seizure diagnosed as conversion disorder and healthy control subjects, and to investigate the neurological status in conversion disorder with pseudoseizure. METHODS: A total of 22 female conversion disorder patients with convulsions diagnosed according to SCID-I/CV and 22 healthy women were included in the assessment. The participants were administered WMS-R, the cancellation test, and the Stroop test as neuropsychological tests and p50 was assessed as a neurophysiological test. RESULTS: The patient's results for the neuropsychological tests were found to be significantly low compared to the control group. The p50 sensory gating ratios of the patient group were statistically significantly lower than the controls. There was no significant correlation between the neuropsychological test scores and gating ratios of the patient and control groups. CONCLUSIONS: This study is the first to check sensory gating in conversion disorder patients with pseudoseizure and its most important result is finding reduced p50 sensory gating in patients. Our results suggest that these patients have a neurological tendency to this disease due to functional neurophysiological features.


Assuntos
Córtex Cerebral/fisiopatologia , Transtorno Conversivo/psicologia , Convulsões/psicologia , Filtro Sensorial/fisiologia , Estimulação Acústica , Adolescente , Adulto , Transtorno Conversivo/fisiopatologia , Eletroencefalografia , Feminino , Humanos , Pessoa de Meia-Idade , Testes Neuropsicológicos , Tempo de Reação/fisiologia , Convulsões/fisiopatologia
7.
Eur Rev Med Pharmacol Sci ; 17(4): 467-71, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23467944

RESUMO

OBJECTIVES: In this study, it was aimed to investigate the effect of n-3 fatty acids (n-3 FA) on diethylnitrosamine (DEN) toxicity with respect to alterations including nitric oxide (NO) formation, uric acid level as well as some liver related enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in rats. MATERIALS AND METHODS: Forty male Wistar albino rats were used as animal materials. Animals were divided into 4 groups and treated as follows: Rats in group 1 (control) were intraperitoneally (i.p) injected with single dose of saline; rats in group 2 were i.p. injected with DEN at a dose of 150 mg/kg/body weight; rats in group 3 were treated with DEN (via single i.p. injection at 150 mg/kg/body weight) plus n-3 FA (at a dose of 0.4 g /kg/day via subcutaneous route in fish oil) for 7 days, and group 4 received n-3 FA via s.c. route at a dose of 0.4 g/kg/day in fish oil for 7 days. The plasma samples were analyzed for NO, uric acid levels as well as for activities of AST, ALT and ALP. RESULTS: Uric acid level was lower in DEN group than in control. In addition, NO level and AST, ALT, ALP activities in DEN group were significantly higher than in control. Nitric oxide concentration, ALT and ALP activities in DEN + n-3 FA treated rats were lower than in DEN alone. Uric acid level in DEN + n-3 FA group was higher than in DEN group. CONCLUSIONS: These results suggest that n-3 fatty acids could ameliorate the toxic effects of DEN in part by means of its free radical scavenging activity and may be of therapeutic value in the protection of liver against toxic effects of DEN.  


Assuntos
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle , Dietilnitrosamina/toxicidade , Ácidos Graxos Ômega-3/uso terapêutico , Sequestradores de Radicais Livres/uso terapêutico , Animais , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Ácidos Graxos Ômega-3/administração & dosagem , Sequestradores de Radicais Livres/administração & dosagem , Testes de Função Hepática , Masculino , Óxido Nítrico/sangue , Ratos , Ratos Wistar , Ácido Úrico/sangue
8.
Acta Chir Belg ; 113(3): 182-6, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24941713

RESUMO

INTRODUCTION: Aorto-bifemoral graft bypass operation is performed in the surgical treatment of aortoiliac occlusive occlusive disease. The conventional standard technique used is the median laparotomy and transperitoneal approach. In this study we evaluated the outcome of aortobifemoral bypass operation via paramedian and retroperitoneal approach. METHODS: 17 patients were operated upon for aortobiiliac occlusive disease from January 2008 through December 2011. Mean age of the patients was 61.8 +/- 8.9 (47-78 years). All patients except for one were operated via left paramedian vertical 8 to 10 cm incision approximately 6 cm to the left or right of midline, extending from a few centimeters above the umbilicus to just above the symphysis pubis. The aortas were reached retroperitoneally through this incision. RESULTS: There was one postoperative death secondary to pulmonary complications. No intraoperative or postoperative surgical complication had occured. All patients were discharged from the hospital on antiplatelet therapy. Graft patency was evaluated by means of physical examination on discharge. Upon the patients' hospital discharge, primary graft patency was 100%. The ankle-brachial indices measured from both the right and left sides were 0.51 +/- 0.10 preoperatively and 0.99 +/- 0.14 postoperatively (p <0.001). DISCUSSION: A lot of complications can be observed due to median laparotomy such as evisceration, incisional hernia, peritonitis, bride ileus. We believe that retroperitoneal approach for aorto-bifemoral graft bypass operation in the patients with bilateral iliac arterial occlusive disease is a well tolerated minimally invasive operation when compared to the conventional median laparotomy approach.


Assuntos
Doenças da Aorta/cirurgia , Arteriopatias Oclusivas/cirurgia , Implante de Prótese Vascular/métodos , Artéria Ilíaca/cirurgia , Idoso , Índice Tornozelo-Braço , Rejeição de Enxerto , Humanos , Masculino , Pessoa de Meia-Idade , Espaço Retroperitoneal
9.
AJNR Am J Neuroradiol ; 44(5): 553-561, 2023 05.
Artigo em Inglês | MEDLINE | ID: mdl-37105678

RESUMO

BACKGROUND AND PURPOSE: IDH and TERT mutations might infiltratively manifest within normal-appearing white matter with specific phenotypes such as microstructural changes undetectable by standard MR imaging contrasts but potentially associable with DTI variables. The aim of this retrospective glioma study was to statistically investigate IDH and TERT associations and classifications with DTI reported microstructure in normal-appearing white matter. MATERIALS AND METHODS: Retrospective data from patients imaged between March 2012 and February 2016 were analyzed by grouping them as IDH-TERT subgroups and by IDH and TERT mutation status. DTI variables in the IDH-TERT subgroups were first identified by the Kruskal-Wallis test, followed by Dunn-Sidák multiple comparisons with Bonferroni correction. IDH and TERT mutations were compared with the Mann-Whitney U test. Classification by thresholding was tested using receiver operating characteristic analysis. RESULTS: Of 170 patients, 70 patients (mean age, 43.73 [SD, 15.32] years; 40 men) were included. Whole-brain normal-appearing white matter fractional anisotropy (FA) and relative anisotropy (RA) (P = .002) were significantly higher and the contralateral-ipsilateral hemispheric differences, ΔFA and ΔRA, (P < .001) were significantly lower in IDHonly patients compared with TERTonly, with a higher whole-brain normal-appearing white matter FA and RA (P = .01) and ΔFA and ΔRA (P = .002) compared to double positive patients. Whole-brain normal-appearing white matter ADC (P = .02), RD (P = .001), λ2 (P = .001), and λ3 (P = .001) were higher in IDH wild-type. Whole-brain normal-appearing white matter λ1 (AD) (P = .003), FA (P < .001), and RA (P = .003) were higher, but Δλ1 (P = .002), ΔFA, and ΔRA (P < .001) were lower in IDH mutant versus IDH wild-type. ΔFA (P = .01) and ΔRA (P = .02) were significantly higher in TERT mutant versus TERT wild-type. CONCLUSIONS: Axial and nonaxial diffusivities, anisotropy indices in the normal-appearing white matter and their interhemispheric differences demonstrated microstructural differences between IDH and TERT mutations, with the potential for classification methods.


Assuntos
Glioma , Telomerase , Substância Branca , Humanos , Substância Branca/diagnóstico por imagem , Estudos Retrospectivos , Anisotropia , Glioma/diagnóstico por imagem , Glioma/genética , Mutação , Encéfalo , Telomerase/genética
10.
Am J Nephrol ; 35(4): 356-64, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22473220

RESUMO

BACKGROUND/AIMS: We previously reported that patients with chronic kidney disease (CKD) receiving warfarin therapy and whose international normalized ratio increases to >3.0 may develop acute kidney injury (AKI) as a result of glomerular hemorrhage and formation of obstructive red blood cell (RBC) casts. We named this condition warfarin-related nephropathy (WRN). We also previously reported that acute excessive anticoagulation with brodifacoum (superwarfarin) induces AKI in 5/6 nephrectomy (5/6NE) rats. Limitations of the brodifacoum model precluded a careful assessment of dose-response relationships. METHODS: Warfarin treatment was used in 5/6NE. RESULTS: Herein we report that warfarin treatment of 5/6NE rats resulted in a dose-dependent increase in serum creatinine (SC). The increase in SC following warfarin treatment was greater at 3 and 19 weeks after the ablative surgery, than that observed 8 weeks after the ablative surgery. The SC increase was correlated with the prothrombin time increase. Morphologically, 5/6NE, but not control rats, had acute tubular injury with RBC and RBC casts in the tubules. Treatment with vitamin K prevented SC increase and morphologic changes in the kidney associated with warfarin treatment. A single episode of WRN did not affect the progression of CKD in 5/6NE. CONCLUSION: (1) The 5/6NE model of CKD is an appropriate animal model to study the pathogenesis of WRN. (2) The pharmacokinetics of warfarin is better suited to the study of WRN than that of brodifacoum. (3) The more advanced stages of 5/6NE are more susceptible to WRN than the earlier stages. (4) Vitamin K treatment prevents WRN.


Assuntos
Injúria Renal Aguda/sangue , Injúria Renal Aguda/induzido quimicamente , Creatinina/sangue , Modelos Animais , Tempo de Protrombina , Varfarina/efeitos adversos , Injúria Renal Aguda/patologia , Injúria Renal Aguda/prevenção & controle , Análise de Variância , Animais , Antifibrinolíticos/uso terapêutico , Humanos , Coeficiente Internacional Normatizado , Masculino , Nefrectomia , Ratos , Ratos Sprague-Dawley , Vitamina K/uso terapêutico
11.
Eur Rev Med Pharmacol Sci ; 16(5): 660-6, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22774408

RESUMO

PURPOSE: The aim of this study was to compare the correlation between bispectral index (BIS) monitor and four commonly used subjective clinical scales (Ramsay Sedation Scale (RSS), Richmond Agitation Sedation Scale (RASS), Sedation Agitation Scale, Adaptation to Intensive Care Environment scale) in mechanically ventilated patients in intensive care unit (ICU). In addition, comparison of responsiveness of the clinical scales in respect to BIS changes is another goal of this study. MATERIALS AND METHODS: Mechanically ventilated thirty patients who required sedation for any reason were enrolled to study. Patients who needed neuromuscular blockade, patients with known hearing and visual problems, neurological diseases, anoxic encephalopathy, mental retardation and who developed hemodynamic instability (mean arterial pressure below 60 mmHg) and hypoxemia (sPO2 below 90%) during follow-up were excluded. Starting before the initiation of sedation, first BIS scores then clinical sedation scales were evaluated. This procedure is repeated every 2 hours for 24 hours. RESULTS: All of the four clinical scales were significantly correlated with BIS. BIS and clinical scale values, except Adaptation to Intensive Care Environment scale, showed significant changes compared to baseline after the initiation of sedation. Ramsay and Richmond scales showed the highest correlation with BIS (respectively, r = 0.758, r = 0.750). Adaptation to Intensive Care Environment revealed the lowest correlation (r = 0.565). CONCLUSIONS: All of the scales were significantly correlated with BIS. RSS and RASS showed higher correlation than other scales. As a conclusion: RSS and RASS can be used for monitoring the depth of sedation in mechanically ventilated patients in ICU.


Assuntos
Monitores de Consciência , Estado de Consciência/efeitos dos fármacos , Indicadores Básicos de Saúde , Hipnóticos e Sedativos/uso terapêutico , Unidades de Terapia Intensiva , Monitorização Fisiológica , Respiração Artificial , APACHE , Adulto , Idoso , Análise de Variância , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Monitorização Fisiológica/instrumentação , Monitorização Fisiológica/métodos , Valor Preditivo dos Testes , Agitação Psicomotora , Fatores de Tempo , Turquia
12.
Sci Immunol ; 7(68): eabi9126, 2022 02 04.
Artigo em Inglês | MEDLINE | ID: mdl-35119939

RESUMO

Neutrophils are the first nonresident effector immune cells that migrate to a site of infection or inflammation; however, improper control of neutrophil responses can cause considerable tissue damage. Here, we found that neutrophil responses in inflamed or infected skin were regulated by CCR7-dependent migration and phagocytosis of neutrophils in draining lymph nodes (dLNs). In mouse models of Toll-like receptor-induced skin inflammation and cutaneous Staphylococcus aureus infection, neutrophils migrated from the skin to the dLNs via lymphatic vessels in a CCR7-mediated manner. In the dLNs, these neutrophils were phagocytosed by lymph node-resident type 1 and type 2 conventional dendritic cells. CCR7 up-regulation on neutrophils was a conserved mechanism across different tissues and was induced by a broad range of microbial stimuli. In the context of cutaneous immune responses, disruption of CCR7 interactions by selective CCR7 deficiency of neutrophils resulted in increased antistaphylococcal immunity and aggravated skin inflammation. Thus, neutrophil homing to and clearance in skin-dLNs affects cutaneous immunity versus pathology.


Assuntos
Inflamação/imunologia , Linfonodos/imunologia , Neutrófilos/imunologia , Receptores CCR7/imunologia , Pele/imunologia , Infecções Estafilocócicas/imunologia , Animais , Feminino , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Receptores CCR7/deficiência
13.
BJOG ; 118(10): 1216-22, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21585645

RESUMO

OBJECTIVE: To review the clinical and demographic characteristics of pregnant and postpartum women who died as a consequence of influenza A H1N1 (2009) infection in Turkey. DESIGN: A review of the records for pregnant and postpartum women who died as a consequence of H1N1 influenza virus infection. SETTING: Nationwide in Turkey. POPULATION: Thirty-six pregnant or postpartum women who died as a result of confirmed pandemic H1N1 influenza virus infection. METHODS: Using the General Directorate of Mother and Child Health and Family Planning (MCHFP) Registry of the Ministry of Health of Turkey, we identified all pregnant and postpartum women who died as a result of confirmed influenza A H1N1 (2009) infection between 29 October and 31 December 2009. MAIN OUTCOME MEASURE: Maternal mortality as a result of H1N1 virus infection. RESULTS: The average time from symptom onset to initial presentation for health care was approximately 2.5 days, and the mean time from symptom onset to the receipt of antiviral medication was approximately 5.5 days. Only one-fifth of all women received early antiviral treatment (administered 2 days or less after symptom onset) and only one woman was vaccinated for H1N1 influenza 1 week before the onset of symptoms. The cause-specific maternal mortality ratio for H1N1 influenza infection in Turkey was estimated to be 3.01. The calculated risk of death associated with H1N1 influenza virus infection was approximately four times higher in pregnant and postpartum women than in the general population (relative risk, 3.88; 95% confidence interval, 2.77-5.43). CONCLUSIONS: Pregnant women are at increased risk for complications of, and death from, H1N1 influenza infection. Prompt evaluation and antiviral treatment of influenza-like illness should be considered in such women. Vaccination for H1N1 influenza may reduce the total number of deaths in pregnant and postpartum women. The high cause-specific maternal mortality rate suggests that H1N1 influenza virus infection may have increased the 2009 maternal mortality ratio in Turkey.


Assuntos
Vírus da Influenza A Subtipo H1N1 , Influenza Humana/mortalidade , Complicações Infecciosas na Gravidez/mortalidade , Adulto , Feminino , Humanos , Gravidez , Infecção Puerperal , Turquia/epidemiologia
14.
B-ENT ; 7(4): 267-71, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22338239

RESUMO

OBJECTIVE: The aim of the study was to evaluate the clinical features and treatment outcomes of patients with a thyroglossal duct cyst (TGDC) or fistula. METHODS: The records of 49 patients (9 female, 40 male; mean age: 23.16 +/- 1.13 years; range 6 to 56 years) operated on between January 1995 and July 2009 were reviewed retrospectively. Patient's age, sex, duration of symptoms, clinical features, pre-operative diagnostic tests, treatment, histopathologic diagnosis, and post-operative complications were noted. All patients underwent the Sistrunk procedure. RESULTS: Fifteen patients (30.6%) were < or = 20 years old, while 3 (6.1%) patients were 40 years old at the time of operation. There was cyst formation in 26 patients (53.1%) and fistula formation in 23 patients (46.9%). The lesions of 41 patients (83.7%) were located in the midline, while the lesions of 8 patients (16.3%) were located in the paramedian neck (5 left side, 3 right side). The most common presenting symptoms were painless mass in the midline of the neck and recurrent suppuration of fistula formation. Neck ultrasonography (USG) was the most common pre-operative diagnostic procedure and was performed on all patients with cyst formations. There were no major complications postoperatively. There was recurrence in only one patient after the Sistrunk procedure. One patient was incidentally diagnosed with thyroid papillary carcinoma after histopathological examination. CONCLUSIONS: A TGDC is the most common congenital mass in the neck and is usually located midline. USG is suggested for a clinically suspected TGDC. The Sistrunk procedure is a safe and successful technique with low complication and recurrence rates. Even though carcinomas arising in TGDCs are uncommon, histopathological examination must be routinely performed to confirm the diagnosis and rule out malignancy.


Assuntos
Cisto Tireoglosso/diagnóstico , Cisto Tireoglosso/cirurgia , Adolescente , Adulto , Transformação Celular Neoplásica , Criança , Feminino , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Cisto Tireoglosso/patologia , Adulto Jovem
15.
Nature ; 426(6967): 641-5, 2003 Dec 11.
Artigo em Inglês | MEDLINE | ID: mdl-14668858

RESUMO

In the context of materials science, texture describes the statistical distribution of grain orientations. It is an important characteristic of the microstructure of polycrystalline films, determining various electrical, magnetic and mechanical properties. Three types of texture component are usually distinguished in thin films: random texture, when grains have no preferred orientation; fibre texture, for which one crystallographic axis of the film is parallel to the substrate normal, while there is a rotational degree of freedom around the fibre axis; and epitaxial alignment (or in-plane texture) on single-crystal substrates, where an in-plane alignment fixes all three axes of the grain with respect to the substrate. Here we report a fourth type of texture--which we call axiotaxy--identified from complex but symmetrical patterns of lines on diffraction pole figures for thin films formed by solid-state reactions. The texture is characterized by the alignment of planes in the film and substrate that share the same d-spacing. This preferred alignment of planes across the interface manifests itself as a fibre texture lying off-normal to the sample surface, with the fibre axis perpendicular to certain planes in the substrate. This texture forms because it results in an interface, which is periodic in one dimension, preserved independently of interfacial curvature. This new type of preferred orientation may be the dominant type of texture for a wide class of materials and crystal structures.

16.
Clin Neuropathol ; 29(6): 384-9, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21073843

RESUMO

AIM: the aim of this study was to investigate the pathologic features, proliferation potential and expression of some anti-apoptotic and growth-promoting markers in adult medulloblastomas. METHOD: we analyzed the immunohistochemical expression of survivin, c-KIT, Bcl-2, fascin, p-53 and Ki-67 in 18 adult medulloblastomas (> 16 years of age). RESULTS: study included 14 males and 4 females (mean age: 22.9 ± 8.2). 14 cases were classical, 2 desmoplastic/nodular and 2 large cell medulloblastomas. Moderate-to-high nuclear survivin expression was observed with high percentages (55 - 100%) in all medulloblastomas while Bcl-2 was mildly positive in only 1 case. Interestingly, mild-to-moderate cytoplasmic c-KIT expression was demonstrated in 16 cases (89%) without membranous accentuation. Fascin expression was observed in 13 medulloblastomas (72%), 9 of which showing moderate to high immunoreactivity. Mild p53 expression was present in only 4 cases (22%). Mean Ki-67 index was 20.6% (range 8 - 55%). CONCLUSION: frequent nuclear survivin expression implies the predominance of anti-apoptotic factors in pathogenesis of adult medulloblastomas. It may also be a potential therapeutic target for adult medulloblastomas. Although Blc-2 immunoreactivity was previously reported in approximately 30% in medulloblastomas, we have observed that it is rarely expressed in the present series of adult medulloblastomas. To our knowledge, this is the first study evaluating fascin expression in medulloblastomas. Its presence may be related to the neuronal differentiation. Mild-to-moderate cytoplasmic c-KIT immunoreactivity without membranous staining in adult medulloblastomas may support the previous studies reporting low level of c-KIT protein expression with lack of activating mutations in medulloblastomas. It seems p53 is rarely involved in the course of develepment of adult medulloblastomas.


Assuntos
Proteínas Reguladoras de Apoptose/metabolismo , Neoplasias Cerebelares/metabolismo , Substâncias de Crescimento/metabolismo , Meduloblastoma/metabolismo , Adolescente , Adulto , Biomarcadores Tumorais/metabolismo , Proteínas de Transporte/metabolismo , Neoplasias Cerebelares/patologia , Feminino , Humanos , Proteínas Inibidoras de Apoptose , Masculino , Meduloblastoma/patologia , Proteínas dos Microfilamentos/metabolismo , Proteínas Associadas aos Microtúbulos/metabolismo , Pessoa de Meia-Idade , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Proteínas Proto-Oncogênicas c-kit/metabolismo , Estudos Retrospectivos , Survivina , Proteína Supressora de Tumor p53/metabolismo , Adulto Jovem
19.
Arch Gynecol Obstet ; 280(6): 971-4, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19319548

RESUMO

PURPOSE: To investigate the coexistentence of anal incontinence (AI) in patients with urinary incontinence (UI). MATERIALS AND METHODS: UDI 6 questionnaire was applied to consecutive 800 patients for the determination of symptomatic UI. Cases were also questioned for AI. The patients with the complaint of UI were evaluated for the coexistence of AI. Each patient with AI, had completed the Cleveland Clinic Florida Fecal Incontinence questionnaire for the determination of the severity of AI. Chi-square and Mann-Whitney U test were used for the evaluation of qualitative data. Multivariable analysis using logistic regression was done to test the overall significance of all variables that were significantly associated with UI using univariate analysis. RESULTS: There were 233 (29.1%) cases of UI and 105 (13.1%) cases of AI. 60 (7.5%) of these patients were suffering from both UI and AI. 60 (57.1%) of 105 patients with AI also had UI. In patients with UI, the coexistence of AI was found in 25.7%. There was a positive correlation between UI and AI (R = 0.240, Chi-square P < 0.001). In logistic regression model, AI [(OR) 3.5, 95% confidence interval 2.26, 5.49], parity and episiotomy were found to be associated with UI. Parity and vaginal delivery by episiotomy were risk factors for the occurrence of AI. CONCLUSION: AI is positively correlated with UI patients. Symptoms of AI must be questioned in all gynecology patients. Unnecessary episiotomy should be avoided.


Assuntos
Incontinência Fecal/complicações , Incontinência Urinária/complicações , Adulto , Episiotomia/efeitos adversos , Incontinência Fecal/fisiopatologia , Feminino , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , Análise Multivariada , Inquéritos e Questionários , Incontinência Urinária/fisiopatologia
20.
J Hazard Mater ; 161(1): 499-509, 2009 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-18508194

RESUMO

In this study, the immobilization of 8-hydroxy quinoline onto bentonite was carried out and it was then used to investigate the adsorption behavior of lead(II) ions from aqueous solutions. The changes of the parameters of pH, contact time, initial lead(II) ions concentration and temperature were tested in the adsorption experiments. The XRD, FTIR, elemental and thermal analyses were done to observe the immobilization of 8-hydroxy quinoline onto natural bentonite. The adsorption was well described by the Langmuir adsorption isotherm model at all studied temperatures. The maximum adsorption capacity was 142.94mgg(-1) from the Langmuir isotherm model at 50 degrees C. The thermodynamic parameters implied that the adsorption process is spontaneous and endothermic. The kinetic data indicate that the adsorption fits well with the pseudo-second-order kinetic model. 8-Hydroxy quinoline-immobilized bentonite can be used as well respective adsorbent for the removal of the heavy metal pollutants according to the results.


Assuntos
Bentonita/química , Chumbo/química , Quinolonas/química , Adsorção , Cátions/química , Concentração de Íons de Hidrogênio , Cinética , Chumbo/isolamento & purificação , Estrutura Molecular , Espectroscopia de Infravermelho com Transformada de Fourier , Temperatura , Termodinâmica , Termogravimetria , Fatores de Tempo , Difração de Raios X
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