Detalhe da pesquisa
1.
Clinical targeting of HIV capsid protein with a long-acting small molecule.
Nature
; 584(7822): 614-618, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32612233
2.
Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).
Bioorg Med Chem Lett
; 28(3): 541-546, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29254643
3.
Inhibitions of late INa and CaMKII act synergistically to prevent ATX-II-induced atrial fibrillation in isolated rat right atria.
J Mol Cell Cardiol
; 94: 122-130, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27066997
4.
In Vitro Antiviral Activity and Resistance Profile Characterization of the Hepatitis C Virus NS5A Inhibitor Ledipasvir.
Antimicrob Agents Chemother
; 60(3): 1847-1853, 2016 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26824950
5.
Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.
Biochemistry
; 54(13): 2240-8, 2015 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25774576
6.
A small-molecule inhibitor of hepatitis C virus infectivity.
Antimicrob Agents Chemother
; 58(1): 386-96, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24165192
7.
Study of marine natural products including resorcyclic acid lactones from Humicola fuscoatra that reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells.
J Nat Prod
; 77(3): 618-24, 2014 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24495105
8.
Kinetic mechanisms of Ca++/calmodulin dependent protein kinases.
Arch Biochem Biophys
; 506(2): 130-6, 2011 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21081101
9.
3,5-diarylazoles as novel and selective inhibitors of protein kinase D.
Bioorg Med Chem Lett
; 21(5): 1447-51, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21300545
10.
Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex.
J Biol Chem
; 284(48): 33580-99, 2009 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19801648
11.
Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1.
Biochim Biophys Acta
; 1789(5): 422-31, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19414071
12.
Novel hepatitis C virus reporter replicon cell lines enable efficient antiviral screening against genotype 1a.
Antimicrob Agents Chemother
; 54(8): 3099-106, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20516274
13.
Homogeneous BTK Occupancy Assay for Pharmacodynamic Assessment of Tirabrutinib (GS-4059/ONO-4059) Target Engagement.
SLAS Discov
; 23(9): 919-929, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30011241
14.
High-throughput kinetic screening of hybridomas to identify high-affinity antibodies using bio-layer interferometry.
J Biomol Screen
; 20(4): 498-507, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25425568
15.
Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism.
Org Lett
; 17(2): 262-5, 2015 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25560385
16.
Lipid-sensing high-throughput ApoA-I assays.
J Biomol Screen
; 17(8): 1050-61, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22811478
17.
Screening of hepatitis C virus inhibitors using genotype 1a HCV replicon cell lines.
Curr Protoc Microbiol
; Chapter 17: Unit17.7, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21805689
18.
Optimized high-throughput screen for hepatitis C virus translation inhibitors.
J Biomol Screen
; 16(2): 211-20, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21297107
19.
Screening and identification of a novel class of TGF-ß type 1 receptor kinase inhibitor.
J Biomol Screen
; 16(7): 724-33, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21521800
20.
Identification of orally available naphthyridine protein kinase D inhibitors.
J Med Chem
; 53(15): 5400-21, 2010 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20684591