Fibrosis in canine transmissible venereal tumor after chemotherapy with vincristine.

The canine transmissible venereal tumor is type of transmissible cancer that occurs naturally through allogenic cellular transplants. Commonly diagnosed in the genital area of sexually active dogs, the tumor typically responds well to vincristine sulfate chemotherapy, although there are cases of resistance to the drug correlated with the tumoral phenotype. We describe herein a case of fibrosis in an area affected by the tumor in a dog after vincristine chemotherapeutic treatment that was associated with an idiosyncratic reaction to the drug.

O tumor venéreo transmissível canino é um tipo de câncer transmissível que ocorre naturalmente através do transplante celular alogênico. Comumente diagnosticado na área genital de cães sexualmente ativos, o tumor normalmente responde bem à quimioterapia com sulfato de vincristina, embora existam casos de resistência à droga correlacionados com o fenótipo tumoral. Descrevemos neste relato de caso um cão com fibrose na área acometida pelo tumor após o tratamento quimioterápico com vincristina associado a uma reação idiossincrática à droga.

Primary surgical repair of prostatic urethral rupture following multiple pelvic fracture in a dog

Abdominal urethral rupture commonly occurs in male dogs after traumatic pelvic fractures and can lead to uroperitoneum, causing peritonitis and azotemia. The primary complications of urethral damage include strictures, incontinence and innervation injury. Here, we describe a case report of prostatic urethral rupture, treated by primary suture repair, that yielded early healing and recovery in a ten-year-old, male, mixed-breed dog who visited our facility within 24 hours of being struck by a car. Positive contrast urethrocystography resulted in leakage of the contrast medium into the abdominal cavity in a point caudal to the urinary bladder. Additional radiography revealed multiple pelvic fractures. During surgery, we found a laceration of the right prostatic lobe causing urethral rupture. We performed a full thickness simple continue suture with 7-0 polyglactin 910 to reestablish urethral continuity. The prostate capsule was also sutured in a simple continue pattern. A previously placed indwelling urinary catheter was kept inside to divert urine flow. On the third postoperative day, the animal withdrew the urinary catheter and started to urinate by himself. The conservative treatment of pelvic fractures enabled complete return to function on the 55th day. One hundred and fifty days after the trauma, no evidence of urinary stricture or another clinical sign was observed. Urethral wounds can be treated surgically by primary suturing and urinary diversion. A short healing time was experienced, and the indwelling urinary catheter was removed three days after surgery since there was no more urine leakage and the animal began voiding normally.

Primary surgical repair of prostatic urethral rupture following multiple pelvic fracture in a dog

Abdominal urethral rupture commonly occurs in male dogs after traumatic pelvic fractures and can lead to uroperitoneum, causing peritonitis and azotemia. The primary complications of urethral damage include strictures, incontinence and innervation injury. Here, we describe a case report of prostatic urethral rupture, treated by primary suture repair, that yielded early healing and recovery in a ten-year-old, male, mixed-breed dog who visited our facility within 24 hours of being struck by a car. Positive contrast urethrocystography resulted in leakage of the contrast medium into the abdominal cavity in a point caudal to the urinary bladder. Additional radiography revealed multiple pelvic fractures. During surgery, we found a laceration of the right prostatic lobe causing urethral rupture. We performed a full thickness simple continue suture with 7-0 polyglactin 910 to reestablish urethral continuity. The prostate capsule was also sutured in a simple continue pattern. A previously placed indwelling urinary catheter was kept inside to divert urine flow. On the third postoperative day, the animal withdrew the urinary catheter and started to urinate by himself. The conservative treatment of pelvic fractures enabled complete return to function on the 55th day. One hundred and fifty days after the trauma, no evidence of urinary stricture or another clinical sign was observed. Urethral wounds can be treated surgically by primary suturing and urinary diversion. A short healing time was experienced, and the indwelling urinary catheter was removed three days after surgery since there was no more urine leakage and the animal began voiding normally.(AU)

Traumatic spinal cord injury with Schiff-Sherrington posture and spontaneous resolution in a dog: MRI evaluation / Trauma medular com postura de schiff-sherrington e resolução espontânea em um cão: avaliação com ressonância magnética

The Schiff-Sherrington phenomenon is an extensor hypertonicity of the forelimbs that occurs when there is a severe injury in the thoracolumbar segment. A 4-years-old, intact female, mixed breed dog, presented with vehicle trauma history followed by non-ambulatory paraparesis, extensor rigidity of forelimb and allodynia pain sensation. Superficial pain sensation was decreased. The treatment was based on unique dose of dexamethasone followed by oral administration of meloxicam, tramadol hydrochloride, dypirone, omeprazole and, poly vitamin complex. Low field magnetic resonance image (MRI) showed hyperintensity signal between T12 and T13 on T2-wheighting image compatible with neuronal edema. In the day after, allodynia and extensor rigidity presented spontaneously resolution. At 10th day, return to voluntary ambulation without assistance. Schiff-Sherrington posture is usually associated with poor prognosis and grade V traumatic injury of the thoracolumbar spinal cord. We report a grade III traumatic spinal cord injury confirmed with MRI as only neuronal edema causing the posture. The Schiff-Sherrington posture often resolves spontaneously in 10-14 days, but neurological signs of trauma can persist. The conservative treatment proposed was efficient, promoting forelimb recovery on the day after and total recovery of motor function in 10 days.

O fenômeno Schiff-Sherrington é a hipertonicidade extensores dos membros torácicos que ocorre quando há lesão severa do seguimento de medula espinhal toracolombar. Uma canina, fêmea, sem raça definida de 4 anos de idade foi apresentada após trauma por automóvel seguido de paraparesia não ambulatória, rigidez extensora dos membros torácicos e sensação dolorosa classificada como alodinia. A dor superficial estava diminuída. O tratamento se baseou na administração única de dexametasona seguida da prescrição de meloxicam, cloridrato de tramadol, dipirona, omeprazol e complexos vitamínicos. A ressonância magnética de baixo campo demonstrou hiperintesidade de sinal entre T12 e T13 nas sequencias ponderadas em T2, o que é compatível com edema neuronal. No dia seguinte, alodinia e a rigidez extensora apresentaram resolução espontânea. No 10º dia, houve retorno a deambulação voluntária sem assistência. A postura de Schiff-Sherington está geralmente associada a prognóstico ruim e lesões traumáticas grau V da medula espinhal toracolombar. Relata-se uma lesão medular traumática grau III confirmada por ressonância magnética somente como edema neuronal levando à posição. A postura de Schiff-Sherrington frequentemente se resolve espontaneamente em 10- 14 dias, mas sinais neurológicos podem persistir. O tratamento conservativo proposto foi eficiente, promovendo recuperação dos membros torácicos no dia seguinte e a recuperação total da função motora em 10 dias.

Traumatic spinal cord injury with Schiff-Sherrington posture and spontaneous resolution in a dog: MRI evaluation / Trauma medular com postura de schiff-sherrington e resolução espontânea em um cão: avaliação com ressonância magnética

The Schiff-Sherrington phenomenon is an extensor hypertonicity of the forelimbs that occurs when there is a severe injury in the thoracolumbar segment. A 4-years-old, intact female, mixed breed dog, presented with vehicle trauma history followed by non-ambulatory paraparesis, extensor rigidity of forelimb and allodynia pain sensation. Superficial pain sensation was decreased. The treatment was based on unique dose of dexamethasone followed by oral administration of meloxicam, tramadol hydrochloride, dypirone, omeprazole and, poly vitamin complex. Low field magnetic resonance image (MRI) showed hyperintensity signal between T12 and T13 on T2-wheighting image compatible with neuronal edema. In the day after, allodynia and extensor rigidity presented spontaneously resolution. At 10th day, return to voluntary ambulation without assistance. Schiff-Sherrington posture is usually associated with poor prognosis and grade V traumatic injury of the thoracolumbar spinal cord. We report a grade III traumatic spinal cord injury confirmed with MRI as only neuronal edema causing the posture. The Schiff-Sherrington posture often resolves spontaneously in 10-14 days, but neurological signs of trauma can persist. The conservative treatment proposed was efficient, promoting forelimb recovery on the day after and total recovery of motor function in 10 days.(AU)

O fenômeno Schiff-Sherrington é a hipertonicidade extensores dos membros torácicos que ocorre quando há lesão severa do seguimento de medula espinhal toracolombar. Uma canina, fêmea, sem raça definida de 4 anos de idade foi apresentada após trauma por automóvel seguido de paraparesia não ambulatória, rigidez extensora dos membros torácicos e sensação dolorosa classificada como alodinia. A dor superficial estava diminuída. O tratamento se baseou na administração única de dexametasona seguida da prescrição de meloxicam, cloridrato de tramadol, dipirona, omeprazol e complexos vitamínicos. A ressonância magnética de baixo campo demonstrou hiperintesidade de sinal entre T12 e T13 nas sequencias ponderadas em T2, o que é compatível com edema neuronal. No dia seguinte, alodinia e a rigidez extensora apresentaram resolução espontânea. No 10º dia, houve retorno a deambulação voluntária sem assistência. A postura de Schiff-Sherington está geralmente associada a prognóstico ruim e lesões traumáticas grau V da medula espinhal toracolombar. Relata-se uma lesão medular traumática grau III confirmada por ressonância magnética somente como edema neuronal levando à posição. A postura de Schiff-Sherrington frequentemente se resolve espontaneamente em 10- 14 dias, mas sinais neurológicos podem persistir. O tratamento conservativo proposto foi eficiente, promovendo recuperação dos membros torácicos no dia seguinte e a recuperação total da função motora em 10 dias.(AU)