Treatment of psoriasis with different classes of biologics reduces the likelihood of peripheral and axial psoriatic arthritis development.

OBJECTIVE: To assess the potential role of biological treatment for psoriasis (PsO) in reducing the likelihood of psoriatic arthritis (PsA), through a detailed analysis that considered the different historical phases in the PsA management, the different biologics classes, and the different patterns of articular involvement. METHODS: A monocentric cohort of 1023 PsO patients underwent a rheumatologic assessment in which clinical and therapeutic data were recorded. Chi-squared test and multivariate logistic regression analysis (adjusted for the main PsA risk factors) were performed to compare the likelihood of PsA development in different treatment groups. RESULTS: The PsA prevalence in PsO patients treated at least once with biologics was significantly lower than in patients never treated with biologics (8.9% vs 26.1%, p< 0.001). In multivariate analysis, a significantly (p< 0.01) lower likelihood of PsA development in biologic-treated patients was confirmed in the whole cohort (adjOR 0.228), as well as in the subgroups of patients with PsO onset after 2005 (adjOR 0.264) and after 2014 (adjOR 0.179). Separately analysing the different biologics classes, both the TNF (adjOR 0.206), IL-17 (adjOR 0.051) and IL-23 or 12/23 (adjOR 0.167) inhibitors were significantly (p< 0.01) associated with a lower likelihood of PsA development. Finally, patients treated with biologics had a significantly (p< 0.04) lower prevalence of both pure peripheral PsA (adjOR 0.182) and peripheral PsA with axial involvement (adjOR 0.115). CONCLUSIONS: This study provides meaningful and concordant evidence supporting the significant role of different classes of biologics in reducing the likelihood of peripheral and axial PsA development.

Space for power: feeling powerful over others' behavior affects peri-personal space representation.

We investigated whether and how social power affects the representation of peri-personal space (PPS). We applied a multisensory interaction task to assess PPS representation and the Personal Sense of Power Scale to assess participants' feelings of power over others' behaviors and over others' opinions. In Study 1, we probed PPS representation in a virtual social context. Participants with a higher sense of power showed a less defined differentiation between the close and far space as compared to participants with a lower sense of power. This effect was replicated in Study 2 when participants performed the task in a non-social context (with no person in the scene), but only after they were reminded of an episode of power. Thus, social power-the perception of power over others' behavior-affects the multisensory representation of the self in space by blurring the differentiation between one's own PPS and the space of others.

Sleep disorders and night-shift work in nursing students: a cross-sectional study.

BACKGROUND: University students are known to have higher sleep disorders prevalence than the general population. Among them, nursing students are even more susceptible to sleep disorders. This study evaluates sleep disorders' risk factors among nursing students and their potential association with symptoms and assesses whether night shifts affect sleep quality by increasing the prevalence of sleep disorders. METHODS: A total of 202 nursing students were included; a self-administered questionnaire was used to collect data on sociodemographic and academic characteristics (i.e., gender, age, height, weight, and year of nursing program) and risk factors for sleep disorders (e.g., smoking, lack of physical activity, and coffee intake late in the evening). The survey included the General Health Questionnaire to assess perceived stress, the Sleep and Daytime Habits Questionnaire, and the Epworth Sleepiness Scale to assess sleep disorders symptoms. RESULTS: A high level of perceived stress is associated with sleep disorders symptoms and with poor sleep quality. Daytime symptoms are also associated with smoking. Students who drink coffee late in the evening report fewer nighttime symptoms. Night shifts and their increasing number are not associated with sleep disorders symptoms. The perception of an unsatisfying academic performance is associated with daytime symptoms and poor sleep quality. CONCLUSIONS: Although night shifts seem to not affect sleep quality among nursing students, sleep disorders represent a critical issue in this population since sleep disorders symptoms may result in errors, accidents, or low academic performance.

Animal magnetism in Italy during the nineteenth century: the conflicting relationship with the Catholic Church.

This article explores the relationship between the Catholic Church and animal magnetism. At the beginning of the nineteenth century, the Catholic Church had first tried to stem the rise of animal magnetism in a vague manner, but after a few decades, it eventually put a genuine veto in place. This measure was founded upon the dangers to morality and faith arising from the progressive polarization of the original doctrine in forms related to esotericism. Among the causes of the condemnation by the Congregation of the Holy Office, the primary ones were the naturalist interpretation of the miracles described in the Gospels and in the New Testament, and the possibility of falling under the control of a demonic spirit.

Getting closer: Synchronous interpersonal multisensory stimulation increases closeness and attraction toward an opposite-sex other in female participants.

Experiencing tactile facial stimulation while seeing synchronous stimulations delivered to another's face induces enfacement, i.e. the subjective experience of ownership over the other's face. The synchronous Interpersonal Multisensory Stimulation (IMS) procedure leading to enfacement induces changes beyond the bodily sense of self, such as increased feeling of closeness between self and other. However, evidence for such an influence of IMS on higher-level self-other representations remains limited. Moreover, research has been restricted to settings involving a same-sex other. The current study tested, in female participants, whether IMS could promote social closeness and attraction toward an opposite-sex other. Across two experiments, enfacement with an opposite-sex face was successfully obtained. Synchronous (vs. asynchronous) IMS yielded greater closeness with the other and induced greater Liking and Attraction scores. These novel findings add further evidence to the existence of a link between body representation and social cognition. Implications for interpersonal attraction are discussed.

Being liked or not being liked: A study on social-media exclusion in a preadolescent population.

INTRODUCTION: Social-media can contribute to building up adolescents' relationships, but they might also bring negative exclusionary experiences. Being excluded is a subtle yet hurtful form of relational aggression, which affects people's psychological wellbeing, especially during developmental stages. In this study, we (1) analyzed the effects of social-media exclusion adapting the Ostracism Online paradigm to a cohort of Italian preadolescents (Mage = 11.47, 53% girls) and (2) tested the efficacy of two potential recovery strategies (i.e., social bonds vs. social surrogate). METHOD: Inclusionary status was manipulated through the number of "likes" participants received on a fictitious online social network. In the exclusion condition, participants received fewer likes than everyone else. In the inclusion condition, participants received a similar number of likes of other users. Then, all participants were asked to think of a significant positive relationship with a family member (social bonds), a celebrity (social surrogate), their present moment thoughts (control). RESULTS: Preadolescents who received fewer likes than others reported higher levels of need threat (i.e., belong, self-esteem, meaningful existence, but not control) and negative emotions. Moreover, the social-bonds strategy generally brought a faster psychological recovery from social-media exclusion than the control condition. The efficacy of social-surrogates strategy was greater for boys than for girls, probably due to different choices in their favorite celebrities. CONCLUSION: These findings show how offline life offers compensatory opportunities for adolescents' online life. When the lack of "Likes" signal exclusion on social-media, thinking of an existing social relationship help adolescents to cope with this negative experience.

Gay- and Lesbian-Sounding Auditory Cues Elicit Stereotyping and Discrimination.

The growing body of literature on the recognition of sexual orientation from voice ("auditory gaydar") is silent on the cognitive and social consequences of having a gay-/lesbian- versus heterosexual-sounding voice. We investigated this issue in four studies (overall N = 276), conducted in Italian language, in which heterosexual listeners were exposed to single-sentence voice samples of gay/lesbian and heterosexual speakers. In all four studies, listeners were found to make gender-typical inferences about traits and preferences of heterosexual speakers, but gender-atypical inferences about those of gay or lesbian speakers. Behavioral intention measures showed that listeners considered lesbian and gay speakers as less suitable for a leadership position, and male (but not female) listeners took distance from gay speakers. Together, this research demonstrates that having a gay/lesbian rather than heterosexual-sounding voice has tangible consequences for stereotyping and discrimination.

On the indirect link between virus anthropomorphism and health behavior: Evidence from the pandemic.

Experts and laypeople often describe pathogens and diseases by attributing to these nonhuman entities human-related qualities, mind states, intentions, and emotions (i.e., anthropomorphism). By taking advantage of the last pandemic, the present research was intended to investigate the implications of thinking about a virus in human-like terms for individuals' health-related behaviors. A severity pathway hypothesis (i.e., virus anthropomorphism is linked to higher engagement in preventive behaviors via higher perceived threat of the virus) and an effectiveness pathway hypothesis (i.e., virus anthropomorphism is associated with lower engagement in preventive behaviors via lower perceived effectiveness of such behaviors) were tested. Across two correlational studies (Study 1, N = 392; Study 2, N = 290), we found support only for the latter hypothesis. Study 2 further clarified the link assumed in the effectiveness pathway hypothesis, showing that anthropomorphism was associated with a decrease in the efficacy of preventive behaviors because attributing a mind to the virus diluted the relative sense of personal responsibility for contagion. A similar pattern of results emerged when we considered vaccination intention as the outcome. Contributions and implications of these findings for research on health behavior and anthropomorphism are discussed.

Rethinking students' mental health assessment through GHQ-12: evidence from the IRT approach.

BACKGROUND: The General Health Questionnaire-12 (GHQ-12) is a widely used screening tool for mental health assessment however its traditional scoring methods and cutoffs may not adequately capture the mental health complexities of younger populations. METHODS: This study explores GHQ-12 responses from a sample of university students. Possible differences in means scores considering gender, age, academic field and degree course were assessed through t-test or one-way ANOVA as appropriate. To deeper understanding different levels of severity and individual item impact on general distress measurement, we applied Item-Response-Theory (IRT) techniques (two-parameters logistic model). We compared students' population with a population of workers who underwent a similar psychological evaluation. RESULTS: A total of 3834 university students participated in the study. Results showed that a significant proportion (79%) of students reported psychological distress. Females and younger students obtained significantly higher average scores compared to others. IRT analysis found item-specific variations in mental distress levels, with more indicative items for short-term fluctuations and potential severe mental health concerns. Latent class analysis identified three distinct subgroups among students (including 20%, 37%, 43% of the participants respectively) with different levels of psychological distress severity. Comparison with a population of adults showed that students reported significantly higher scores with differences in the scale behavior. CONCLUSION: Our results highlighted the unique mental health challenges faced by students, suggesting a reevaluation of GHQ-12 applicability and cutoff scores for younger populations, emphasizing the need for accurate instruments in mental health evaluation.

Pleural mesothelioma in situ: a comprehensive review.

Pleural mesothelioma is a rare and aggressive cancer that affects the pleura. In recent years, there has been increasing interest and attention in detecting and diagnosing early-stage or precancerous forms of mesothelioma because of its severe prognosis and short life expectancy at the time of diagnosis. Mesothelioma in situ represents a clear opportunity to improve and innovate the diagnostic approach and the multimodality treatment of mesothelioma: the diagnosis of pleural mesothelioma at the 'in-situ phase' means early disease detection and thus paves the way to new possible curable strategies. Since 2021, when mesothelioma in situ was finally identified and described as a new histological entity, its diagnosis and management became a challenge and the subject of ongoing research; several aspects remain open and still outstanding as regards diagnostic techniques, time and probability of progression, need for and methods of follow up, aggressive and early surgery. This narrative review aims to provide a comprehensive overview of mesothelioma in situ covering its definition, risk factors, diagnostic criteria, and tricky aspects of early detection. It also highlights its clinical significance, new perspectives, and potential future indications in the context of pleural mesothelioma multidisciplinary management.

Reducing economic inequality is 'just right': Moral conviction predicts support for redistributive government policies.

Individuals may support economic redistribution because of practical considerations, but also because they perceive it as morally necessary according to their personal ethical beliefs. Across three studies, we investigated whether attitudes towards reducing economic inequality can be experienced with moral conviction (i.e. perceived as rooted in one's core beliefs about right and wrong) and motivate support for redistributive government policies. In Study 1 (N = 138), reducing economic inequality moral conviction scores were comparable to other highly moralized topics (e.g. euthanasia) and higher than lowly moralized topics (e.g. tattoos). In Study 2 (N = 325) and Study 3 (N = 271), the moral conviction for reducing economic inequality positively predicted support for several redistributive government policies. Additionally, while empathic concern (Study 2 and 3) provided mixed results, structural causal attributions (Study 3) mediated this effect. Therefore, our findings highlight the importance of personal moral significance in understanding what motivates support for redistributive policies.

[Artificial Intelligence in Medicine. Ethical reflections from the thought of Edmund Pellegrino]. / Inteligencia Artificial en Medicina. Reflexiones éticas desde el pensamiento de Edmund Pellegrino.

The current scenario of health sciences, and of Medicine in particular, is characterized by the growing role of Artificial Intelligence (AI), thus projecting towards the consolidation of a new model of Medicine. Along with the undeniable advantages offered by the application of AI for the diagnosis and treatment of complex clinical problems, some ethical questions arise, which demand careful reflection. However, most of the literature that addresses the ethical issues associated with the use of AI in medicine does so from the poiesis' perspective. Indeed, a large part of that evidence is related to the design, programming, training and operation of algorithms, problems that exceed the competences of the health professionals that use them. Our proposal is framed in the ethics of virtue outlined by Edmund Pellegrino, which is a valuable epistemological perspective to trace a path of reflection on the ethical problems arising from the use of AI in Medicine. This perspective -based on a sound philosophy of Medicine- adopts the praxis' point of view, that is, of the acting subject. Since the health professional is a moral agent who uses AI as a tool to achieve an end -the good of the patient-,from Pellegrino's perspective it is possible to ask how the use of AI might influence the achievement of the goal of medical work and thus, be considered a criterion of ethical orientation.

Of precarity and conspiracy: Introducing a socio-functional model of conspiracy beliefs.

Conspiracy Beliefs (CB) are a key vector of violent extremism, radicalism and unconventional political events. So far, social-psychological research has extensively documented how cognitive, emotional and intergroup factors can promote CB. Evidence also suggests that adherence to CB moves along social class lines: low-income and low-education are among the most robust predictors of CB. Yet, the potential role of precarity-the subjective experience of permanent insecurity stemming from objective material strain-in shaping CB remains largely unexplored. In this paper, we propose for the first time a socio-functional model of CB. We test the hypothesis that precarity could foster increased CB because it undermines trust in government and the broader political 'elites'. Data from the World Value Survey (n = 21,650; Study 1, electoral CB) and from representative samples from polls conducted in France (n = 1760, Study 2a, conspiracy mentality) and Italy (n = 2196, Study 2b, COVID-19 CB), corroborate a mediation model whereby precarity is directly and indirectly associated with lower trust in authorities and higher CB. In addition, these links are robust to adjustment on income, self-reported SES and education. Considering precarity allows for a truly social-psychological understanding of CB as the by-product of structural issues (e.g. growing inequalities). Results from our socio-functional model suggest that implementing solutions at the socio-economic level could prove efficient in fighting CB.

The Evaluation of the Balance Test and MuscleLab Test for the Early Detection of Femoroacetabular Impingement.

Femoroacetabular impingement (FAI) is a common source of hip pain affecting a wide range of subjects. In this work, we assessed two tests, namely the balance test and the MuscleLab test, in comparison with the flexion-abduction-external rotation (FABER) and flexion-adduction-internal rotation (FADIR) tests, in order to evaluate the functionality of the neural-musculoskeletal system of the subjects affected by FAI based on the measurement of biomechanical parameters. Our goal was to investigate the early detection of an altered hip joint and to monitor pathology progression over time. A total of 52 subjects, 29 females and 23 males, with an average age of 42 ± 13 years presenting hip impingement diagnosed using X-ray, were enrolled. Twenty-eight patients without signs of hip impingements were used as the control group. The balance test, which evaluates the capacity of a person to keep the orthostatic position against terrestrial gravity, and the MuscleLab test, which measures the force and power generated by active muscles during a movement, as well as FABER and FADIR tests, were performed in each subject. The balance and MuscleLab tests presented 100% sensitivity and higher sensitivity in FAI diagnosis, with 72.9% and 70.4%, respectively, in comparison with those obtained using FABER and FADIR tests, with 59.6% and 67.3%, respectively. The evaluation of the neural-musculoskeletal system using the balance and MuscleLab tests can help in the early detection of the severity of hip impingements and the assessment of non-operative treatments used over time.

The Challenging Differentiation of Psoriatic Arthritis from Other Arthropathies and Nonspecific Arthralgias in Patients with Psoriasis: Results of a Cross-Sectional Rheumatologic Assessment of a Large Dermatologic Cohort.

Aiming to identify the potential challenges in the classification of musculoskeletal manifestations in patients with psoriasis (PsO), this study analyzed the outcomes of a cross-sectional rheumatologic assessment of 1057 PsO patients. In total, 209 had a previous diagnosis of psoriatic arthritis (PsA). Out of the remaining 848 subjects, 293 (35%) were classified as suspected PsA cases according to the rheumatologist's judgment and/or Early PsA Screening Questionnaire score (EARP) ≥ 3. However, only 14% received a PsA diagnosis, 49% had a PsA-alternative diagnosis, and the remaining 37% had nonspecific arthralgias. Most of the newly diagnosed PsA patients had a symptoms duration ≥1 year (72%) and moderate disease activity (55%) with active oligoarthritis (85%), dactylitis, or enthesitis (35%) as the most frequent clinical pattern. The most frequent PsA-alternative diagnoses were osteoarthritis and fibromyalgia (44% and 41%). The only factors with significant (p < 0.05) utility in discriminating PsA from other diseases and nonspecific arthralgias were young age and EARP score with a history of morning stiffness, swollen joints, or dactylitis. These results demonstrated a high prevalence of suspected musculoskeletal symptoms in PsO patients, with, however, only a small proportion due to PsA. Close collaboration between the dermatologist and rheumatologist plays a crucial role in the differential diagnosis of PsA, as well as in monitoring nonspecific arthralgias for the potential transition to overt PsA.