1.
Org Biomol Chem
; 5(1): 61-4, 2007 Jan 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17164907
RESUMO
A highly effective one-pot Friedländer quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66-100%).
Assuntos
Aldeídos/química , Benzaldeídos/química , Quinolinas/síntese química , Ferro/química , Cetonas/química , Estrutura Molecular , Oxirredução , Quinolinas/química
2.
Bioorg Med Chem Lett
; 16(10): 2729-33, 2006 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16504501
RESUMO
3-[6-(2-Dimethylamino-1-imidazol-1-yl-butyl)-naphthalen-2-yloxy]-2,2-dimethyl-propionic acid and analogs were designed and synthesized as highly potent and selective CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBAs), with demonstrated in vivo efficacy to increase the half-life of exogenous atRA.