Detalhe da pesquisa
1.
Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
Proc Natl Acad Sci U S A
; 119(30): e2203660119, 2022 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35858448
2.
Structure-based design of diarylpyrimidines and triarylpyrimidines as potent HIV-1 NNRTIs with improved metabolic stability and drug resistance profiles.
J Med Virol
; 96(3): e29502, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38450817
3.
Discovery of low-molecular-weight phenylalanine derivatives as novel HIV capsid modulators with improved antiretroviral activity and metabolic stability.
J Med Virol
; 96(4): e29594, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38576317
4.
Structure-guided design of novel biphenyl-quinazoline derivatives as potent non-nucleoside reverse transcriptase inhibitors featuring improved anti-resistance, selectivity, and solubility.
Bioorg Chem
; 147: 107340, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38593532
5.
Structure-Based Design of Novel Thiazolone[3,2-a]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy.
Molecules
; 29(9)2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38731613
6.
In situ click chemistry-based discovery of 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs by exploiting the tolerant region I in binding pocket.
Bioorg Med Chem
; 96: 117484, 2023 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37976805
7.
Development of novel HEPT analogs featuring significantly improved anti-resistance potency against HIV-1 through chemical space exploration of the tolerant region I.
Bioorg Chem
; 140: 106783, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37595396
8.
Structure-directed linker optimization of novel HEPTs as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorg Chem
; 133: 106413, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36791619
9.
Improving the anti-HIV-1 activity and solubility of poorly water-soluble DAPYs by heteroaromatic replacement strategy: From naphthalene-DAPYs to quinoline-DAPYs.
Bioorg Chem
; 140: 106821, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37659148
10.
4-Phenylcoumarin derivatives as new HIV-1 NNRTIs: Design, synthesis, biological activities, and computational studies.
Bioorg Chem
; 141: 106918, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37866206
11.
Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study.
Int J Mol Sci
; 24(2)2023 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36674730
12.
Anti-SARS-CoV-2 Activity and Cytotoxicity of Amaryllidaceae Alkaloids from Hymenocallis littoralis.
Molecules
; 28(7)2023 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37049986
13.
Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein.
J Med Virol
; 94(12): 5975-5986, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35949003
14.
Conformationally Locked Carbocyclic Nucleosides Built on a 4'-Hydroxymethyl-3'-hydroxybicyclo[4.1.0]heptane Template. Stereoselective Synthesis and Antiviral Activity.
J Org Chem
; 87(22): 15166-15177, 2022 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36300902
15.
Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV1 non-nucleoside reverse transcriptase inhibitors.
Bioorg Med Chem
; 53: 116531, 2022 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34890994
16.
Structure-Based design of [(2-Hydroxyethoxy)methyl]-6-(phenylthio)-thymine derivatives as nonnucleoside HIV-1 reverse transcriptase Inhibitors: From HEPTs to Sulfinyl-substituted HEPTs.
Bioorg Chem
; 126: 105880, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35649315
17.
Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses.
Chem Soc Rev
; 50(7): 4514-4540, 2021 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33595031
18.
Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.
Molecules
; 27(21)2022 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36364360
19.
Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators.
Molecules
; 27(23)2022 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36500508
20.
Design, Synthesis and Structure-Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction.
Molecules
; 27(18)2022 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36144727