Age-related changes in scalp biophysical parameters: A comparative analysis of the 20s and 50s age groups.

BACKGROUND: Age-related changes in scalp parameters affect hair quality and scalp condition. However, detailed data on biophysical parameters of the scalp across age groups remain scarce. We aimed to investigate the differences in scalp parameters between individuals in their 20s and 50s and analyze their sex-specific variations. MATERIALS AND METHODS: Two hundred participants (160 women and 40 men) were equally divided into 20s and 50s age groups. Biophysical parameters of the scalp, including elasticity, pH, trans-epidermal water loss (TEWL), sebum production, desquamation, firmness, redness, and yellowness, were measured in the vertex, occipital, and temporal regions. Hair density and thickness were measured in the temporal region. The accumulation of advanced glycation end products (AGEs) in the skin was noninvasively measured in a subset of 60 women. RESULTS: Skin firmness and redness increased with age in women, whereas yellowness increased with age in both sexes. Sebum production and pH levels were significantly lower in the 50s age group than in the 20s age group, particularly in women. TEWL was lower in men in their 50s than in those in their 20s, particularly in the occipital region. A significant reduction in hair density was observed in the 50s age group in both sexes. AGE accumulation in the skin increased with age and was correlated with scalp skin yellowness. CONCLUSION: Age-related changes in scalp parameters have important implications for hair health and scalp condition. These findings emphasize the importance of considering age and sex when developing hair care strategies.

Feasibility, safety, and functional recovery after active rehabilitation in critically ill surgical patients.

BACKGROUND: The characteristics of critically ill surgical patients differ from those of medical patients. Few studies have evaluated rehabilitation in surgical intensive care units (SICUs), particularly in non-Western countries and in elderly patients. OBJECTIVE: The objective of this study was to investigate the rehabilitation characteristics, safety, and functional recovery in non-Western SICU patients. METHODS: Data from patients who received active rehabilitation in 2016 were retrospectively reviewed. Clinical characteristics, functional recovery, and safety were investigated and compared in patients aged <65 or ≥65 years. Potential safety events were also compared between the two age groups and according to the reason for SICU admission. RESULTS: Data from 157 patients were included in the analysis. The number of patients who were able to stand or walk increased from the beginning of rehabilitation to the time of ICU discharge (from 52 to 102 patients, P < 0.01). The Activity Measure for Post-Acute Care (AM-PAC) score also increased during rehabilitation (from 11.6 to 13.9, P < 0.01). Functional recovery did not differ between the two age groups. During 780 rehabilitation sessions, 23 potential safety events (3.0%) were noted; no significant differences were seen between the two age groups. A significant difference was noted when patients were grouped according to the reason for SICU admission (1.7% in postoperative care patients vs 4.5% in patients admitted for other reasons, P = 0.02). CONCLUSIONS: Active rehabilitation in critically ill surgical patients is feasible and safe and resulted in improved mobility, regardless of age. However, the reason for SICU admission should be considered.

Depth profiling of epidermal hydration inducing improvement of skin roughness and elasticity: in vivo study by confocal Raman spectroscopy.

INTRODUCTION: Skin hydration in the stratum corneum plays an important role in skin condition, and skin efficacy properties are influenced by its hydration level. However, few studies have identified the correlation between changes in skin hydration content and skin characteristics by skin depth level. AIMS: This study aims to determine how changes in skin hydration at specific depth levels affect skin condition by long-term tracking changes in hydration of stratum corneum and viable epidermis after usage of moisturizer. METHODS: Ten volunteers were recruited and subjected to in vivo confocal Raman spectroscopy to perform water content profiling at skin depths of up to 52 µm. Mechanical properties of skin were measured using Cutometer and Antera 3D. Skin-elasticity and roughness values observed before and after 15 days of moisturizing emulsion use were compared to demonstrate the correlation between observed changes in skin efficacy parameters and skin water content at specific depths. RESULTS: Significant increase in relative water content at specific depths was observed in this study. Among mechanical properties of skin, only R4, R6, and R8 parameters demonstrated significant changes. Additionally, rates of change in values of the R6 and R8 parameters revealed a high correlation with water content changes at viable epidermis depths below the stratum corneum. On the other hand, skin roughness parameter showed a correlation with water content changes at the outermost layer of stratum corneum. CONCLUSION: Results of this study indicate that skin elasticity is influenced by its hydration level at viable epidermis depths and skin roughness at stratum corneum each. This suggests that monitoring depth profiles of water content using in vivo confocal Raman spectroscopy provides a breakthrough in tracking the skin efficacy effect of topically applied substances.

Inhibitory activity of minor phlorotannins from Ecklonia cava on α-glucosidase.

α-Glucosidase is an enzyme that plays a key role in raising blood sugar level and is considered a good target for developing drugs to treat type 2 diabetes. This study was performed to evaluate the inhibition of the catalytic reaction of α-glucosidase by minor phlorotannin derivatives (1-5) from Ecklonia cava. These derivatives demonstrated inhibitory activity, with IC50 values ranging from 2.3 ±â€¯0.1 to 59.8 ±â€¯0.8 µM. Among the phlorotannins identified, compounds 2 and 3-5 were revealed to be non-competitive and competitive inhibitors, respectively. Furthermore, a fluorescence-quenching study of receptor-ligand binding was performed to calculate the kinetic parameters (Ksv, Kq, and K). These signal data indicated a 1:1 ratio of ligand-receptor binding. The binding conformations of the phlorotannin ligands were visually solved through molecular simulation. In conclusion, these minor phlorotannins may serve as α-glucosidase inhibitors targeted for the treatment of type 2 diabetes.

Entry to ß-alkoxyacrylates via gold-catalyzed intermolecular coupling of alkynoates and allylic ethers.

The first gold-catalyzed intermolecular coupling of alkynoates and allylic ethers invoking alkoxy addition and [3,3]-sigmatropic rearrangement as the key mechanism has been developed. Remarkably, the reaction showed complete chemoselectivity toward the pathway initiated by the alkoxy addition to alkynes. This unprecedented reactivity led to a new access to diversely substituted ß-alkoxyacrylates in a highly efficient manner.