Detalhe da pesquisa
1.
Liquid Chromatography-Multiple Reaction Monitoring-Mass Spectrometry Assay for Quantitative Measurement of Therapeutic Antibody Cocktail REGEN-COV Concentrations in COVID-19 Patient Serum.
Anal Chem
; 93(38): 12889-12898, 2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34463470
2.
Immunogenicity of Cemiplimab: Low Incidence of Antidrug Antibodies and Cut-Point Suitability Across Tumor Types.
J Clin Pharmacol
; 64(1): 125-136, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37656820
3.
Subcutaneous Administration of Monoclonal Antibodies: Pharmacology, Delivery, Immunogenicity, and Learnings From Applications to Clinical Development.
Clin Pharmacol Ther
; 115(3): 422-439, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38093583
4.
2023 White Paper on Recent Issues in Bioanalysis: ISR for ADA Assays, the Rise of dPCR vs qPCR, International Reference Standards for Vaccine Assays, Anti-AAV TAb Post-Dose Assessment, NanoString Validation, ELISpot as Gold Standard (Part 3 - Recommendations on Gene Therapy, Cell Therapy, Vaccines Immunogenicity & Technologies; Biotherapeutics Immunogenicity & Risk Assessment; ADA/NAb Assay/Reporting Harmonization).
Bioanalysis
; 16(7): 77-119, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38389403
5.
Statistical Approaches for Establishing Appropriate Immunogenicity Assay Cut Points: Impact of Sample Distribution, Sample Size, and Outlier Removal.
AAPS J
; 25(3): 37, 2023 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37016171
6.
Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase.
Nat Cell Biol
; 7(6): 581-90, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15895076
7.
Interference in a Neutralizing Antibody Assay for Odronextamab, a CD20xCD3 Bispecific mAb, from Prior Rituximab Therapy and Possible Mitigation Strategy.
AAPS J
; 24(4): 76, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35725847
8.
Assay pH and critical reagent optimization in measuring concentrations of a monoclonal antibody and its target.
Bioanalysis
; 14(8): 491-502, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35297286
9.
Pre-existing Reactivity to an IgG4 Fc-Epitope: Characterization and Mitigation of Interference in a Bridging Anti-drug Antibody Assay.
AAPS J
; 24(4): 78, 2022 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35778641
10.
Comparison of Titer and Signal to Noise (S/N) for Determination of Anti-drug Antibody Magnitude Using Clinical Data from an Industry Consortium.
AAPS J
; 24(4): 81, 2022 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35821280
11.
2021 White Paper on Recent Issues in Bioanalysis: ISR for Biomarkers, Liquid Biopsies, Spectral Cytometry, Inhalation/Oral & Multispecific Biotherapeutics, Accuracy/LLOQ for Flow Cytometry (Part 2 - Recommendations on Biomarkers/CDx Assays Development & Validation, Cytometry Validation & Innovation, Biotherapeutics PK LBA Regulated Bioanalysis, Critical Reagents & Positive Controls Generation).
Bioanalysis
; 14(10): 627-692, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35578974
12.
Suppression of the proinflammatory response of metastatic melanoma cells increases TRAIL-induced apoptosis.
J Cell Biochem
; 112(2): 463-75, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21268068
13.
Quantitation of reduced IL-33 levels in human serum: mitigating interference from endogenous binding partners.
Bioanalysis
; 13(23): 1751-1760, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34758642
14.
Isotyping and Semi-Quantitation of Monkey Anti-Drug Antibodies by Immunocapture Liquid Chromatography-Mass Spectrometry.
AAPS J
; 23(1): 16, 2021 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33404777
15.
Bioanalytical Challenges due to Prior Checkpoint Inhibitor Exposure: Interference and Mitigation in Drug Concentration and Immunogenicity Assays.
AAPS J
; 23(6): 109, 2021 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34608545
16.
REGEN-COV® antibody cocktail bioanalytical strategy: comparison of LC-MRM-MS and immunoassay methods for drug quantification.
Bioanalysis
; 13(24): 1827-1836, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34743612
17.
2020 White Paper on Recent Issues in Bioanalysis: Vaccine Assay Validation, qPCR Assay Validation, QC for CAR-T Flow Cytometry, NAb Assay Harmonization and ELISpot Validation (Part 3 - Recommendations on Immunogenicity Assay Strategies, NAb Assays, Biosimilars and FDA/EMA Immunogenicity Guidance/Guideline, Gene & Cell Therapy and Vaccine Assays).
Bioanalysis
; 13(6): 415-463, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-33533276
18.
Assessment of clinically relevant immunogenicity for mAbs; are we over reporting ADA?
Bioanalysis
; 12(18): 1325-1336, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32946271
19.
Drug Removal Strategies in Competitive Ligand Binding Neutralizing Antibody (NAb) Assays: Highly Drug-Tolerant Methods and Interpreting Immunogenicity Data.
AAPS J
; 22(5): 112, 2020 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32808205
20.
Src SH2 arginine 175 is required for cell motility: specific focal adhesion kinase targeting and focal adhesion assembly function.
Mol Cell Biol
; 26(12): 4399-409, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16738308