Detalhe da pesquisa
1.
γ-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma.
Blood
; 134(19): 1585-1597, 2019 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31558469
2.
Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer.
J Biol Chem
; 292(3): 837-846, 2017 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27909050
3.
Phase 1 Study of JNJ-64619178, a Protein Arginine Methyltransferase 5 Inhibitor, in Advanced Solid Tumors.
Clin Cancer Res
; 29(18): 3592-3602, 2023 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37491846
4.
Integrated analysis of preclinical data to support the design of the first in man study of LY2181308, a second generation antisense oligonucleotide.
Br J Clin Pharmacol
; 71(3): 416-28, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21284701
5.
Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy.
Mol Cancer Ther
; 18(12): 2207-2219, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31530649
6.
Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors.
Oncotarget
; 9(17): 13796-13806, 2018 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29568395
7.
A first-in-human phase I study of the oral Notch inhibitor, LY900009, in patients with advanced cancer.
Eur J Cancer
; 56: 1-9, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26798966
8.
Mitogenic synergy through multilevel convergence of hepatocyte growth factor and interleukin-4 signaling pathways.
Oncogene
; 21(14): 2201-11, 2002 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-11948403
9.
The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines.
Mol Cancer Ther
; 3(1): 1-9, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14749470
10.
Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors.
J Med Chem
; 46(11): 2027-30, 2003 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-12747775
11.
Biomarkers of the Hedgehog/Smoothened pathway in healthy volunteers.
Am J Transl Res
; 4(2): 229-39, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22611475
12.
Antisense inhibition of survivin expression as a cancer therapeutic.
Mol Cancer Ther
; 10(2): 221-32, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21216939
13.
One-step cellular caspase-3/7 assay.
Biotechniques
; 34(5): 1064-7, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12765032
14.
Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors.
Bioorg Med Chem Lett
; 13(7): 1231-5, 2003 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12657252
15.
Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation.
Bioorg Med Chem Lett
; 14(24): 6095-9, 2004 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15546737
16.
Synthesis of 1,7-annulated indoles and their applications in the studies of cyclin dependent kinase inhibitors.
Bioorg Med Chem Lett
; 14(12): 3057-61, 2004 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15149644
17.
1,7-annulated indolocarbazoles as cyclin-dependent kinase inhibitors.
Bioorg Med Chem Lett
; 14(12): 3217-20, 2004 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15149678
18.
Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides.
Bioorg Med Chem Lett
; 13(21): 3841-6, 2003 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-14552792
19.
Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.
Bioorg Med Chem Lett
; 13(14): 2261-7, 2003 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12824014
20.
Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors.
Bioorg Med Chem Lett
; 13(21): 3835-9, 2003 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-14552791