Detalhe da pesquisa
1.
Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement.
Bioorg Med Chem
; 100: 117618, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38309201
2.
Using predictive validity to compare associations between brain damage and behavior.
Hum Brain Mapp
; 44(13): 4738-4753, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37417774
3.
Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo.
J Pharmacol Exp Ther
; 376(3): 436-443, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33376150
4.
A randomized clinical trial to evaluate the single-dose pharmacokinetics, pharmacodynamics, and safety of sitagliptin in pediatric patients with type 2 diabetes.
Pediatr Diabetes
; 20(1): 48-56, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30346099
5.
A computational perspective on autism.
Proc Natl Acad Sci U S A
; 112(30): 9158-65, 2015 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26170299
6.
Reply to Lawson et al.: A synergistic approach to mental health research.
Proc Natl Acad Sci U S A
; 112(38): E5227, 2015 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26358653
7.
Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B-Raf.
J Med Chem
; 64(21): 15651-15670, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34699203
8.
Improving the developability profile of pyrrolidine progesterone receptor partial agonists.
Bioorg Med Chem Lett
; 20(1): 371-4, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19926282
9.
Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions.
J Med Chem
; 63(23): 14867-14884, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33201708
10.
Synthesis and SAR of amino acid-derived heterocyclic progesterone receptor full and partial agonists.
Bioorg Med Chem Lett
; 19(10): 2637-41, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19376703
11.
Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.
Bioorg Med Chem Lett
; 19(15): 4441-5, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19497745
12.
Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4).
ACS Med Chem Lett
; 10(8): 1228-1233, 2019 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31413810
13.
Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4).
J Med Chem
; 62(20): 9270-9280, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31532662
14.
Optimizing the Use of Electronic Data Sources in Clinical Trials: The Landscape, Part 1.
Ther Innov Regul Sci
; 50(6): 682-696, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-30231749
15.
Laropiprant in combination with extended-release niacin does not alter urine 11-dehydrothromboxane B2, a marker of in vivo platelet function, in healthy, hypercholesterolemic, and diabetic subjects.
J Clin Pharmacol
; 49(12): 1426-35, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19833861
16.
A single supratherapeutic dose of vorinostat does not prolong the QTc interval in patients with advanced cancer.
Clin Cancer Res
; 15(22): 7077-84, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19887475
17.
Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.
Cancer Res
; 68(18): 7475-83, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18794135
18.
Investigation into the structure-activity relationship of novel concentration dependent, dual action T-type calcium channel agonists/antagonists.
Bioorg Med Chem
; 13(11): 3821-39, 2005 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15863008
19.
Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists.
Bioorg Med Chem Lett
; 14(14): 3691-5, 2004 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15203145